Laboratory introduction

• Obesity is an increasing, global public health issue associated with increased morbidity and mortality. Patients with obesity are at major risk for developing a range of comorbid conditions, including cardiovascular disease, gastrointestinal disorders, type 2 diabetes, joint and muscular disorders, respiratory problems, and psychological issues, which may significantly affect their daily lives.

• Our laboratory is mainly interested in understanding the molecular mechanisms of regulating systemic glucose/lipid metabolism through liver tissue to improve human diseases such as diabetes, obesity, and metabolic disorders. These studies can be the scientific evidence for developing novel anti-diabetic drugs. Our aim is to identify novel mechanisms for maintaining/regaining metabolic health from a liver-centric perspective and develop novel therapeutics for obesity-related metabolic diseases.

• At MRL, we are at the forefront of metabolic regulation research, exploring the novel gene function associated with metabolic diseases. We elucidate molecular mechanisms and signaling pathways in metabolic regulation. We are paving the way for transformative insights into human health and disease. 

Research Topic

Research Objectives

Research achievements

Ⅰ. Background

Ⅱ. Characterization of novel gene in brain function under Ischemia / Reperfusion injury

Ⅲ . Elucidation of disease-association gene based on molecular mechanism 

 via knockout mouse model

Research goals