In response to the University’s advocacy to transform Palawan State University into “Premier National Research University”, the establishment of PSU-Marine Science Laboratory (PSU-MSL) was conceptualized by Prof. Floredel Dangan-Galon on 10 April 2012. This was subsequently confirmed by the University Board of Regents on 16 May 2012 per BOR Resolution No. 21, series of 2012 and on 14 November, the unit was placed under the office of the Vice President for Research and Extension through Office Order No. 422, series of 2012. In year 2020 to 2021, the unit was placed under the College of Sciences. Currently, it is placed under the office of the Vice President for Research, Development, and Extension as Marine Science Research Center on 31 December 2021 per BOR Res 116 series of 2021.

PSU-MSRC serves as a research facility and/or arm of the University and the coordinating base for marine and aquatic-related researches. Its basic concerns are the marine resources, environment, and the end-users. It works with other units of the university e.g. the Departments of Bio-Physical Sciences, Engineering, Computer Science and Information Technology, among others. It likewise provides laboratory facilities for students, faculty-researchers and associates from national and international research institutions. 

For many decades, Palawan State University's main campus (PSU) has lacked a plant extraction facility. When it comes to plant extractions for plant study, students and researchers rely on non-standardized extraction methods. PSU built the extraction laboratory in the province of Palawan in the third quarter of 2018. This is the province's very first extraction laboratory. The PSU extraction laboratory was created as part of the DOST PCHRD DDHP program, in addition to the production of herbal extracts. The project Herbal extracts from Palawan for Bioactivity and Toxicity Assays was the first step toward the creation of the PSU-Extraction Laboratory, which would have the required facilities to conduct standardized procedures for plant extracts. This idea made possible through Dr. Amor and Dr. Villasenor of UP Diliman collaborations to PSU.

The project began in early January 2018 and completed last February 2020. The project team consists of one project leader, one project member, two research assistants, one laboratory assistant, and one clerk. The Palawan team was tasked for producing 150 plant extracts that investigated for bioactivity and toxicity assay. The tests were carried out at the University of the Philippines Diliman, under the headed by Dr. Amor. A total of 159 plant extracts were sent out to UP Diliman, and three of these extracts shown very high efficacy against Methicillin Resistant Staphyloccus Aureus (MRSA). One plant sample was sent to UP Manila for analysis as a collaboration to Dr. Noel Quiming project. The last two plant samples are about to be gathered. The completion of the project and the epidemic are the bottlenecks for recollection and re-extraction.

The College of Sciences Instrumentation Laboratory was established on January 17, 2024. The laboratory equipment was donated by Coral Bay Nickel Corporation (CBNC). The Laboratory is equipped to meet the diverse laboratory requirements of BS Environmental Science, BS Marine Biology, and BS Medical Biology programs. It features analytical balances, vacuum filtration setups, UV/Vis spectrophotometers, rotary evaporators, compound microscopes, and bacteriological test setups, facilitating physical, chemical, and microbiological analyses. The equipment supports various research endeavors, including water quality testing, phytochemical screening of plant extracts, and bacteriological analysis of environmental samples, enabling comprehensive investigation into environmental, biological, and medical phenomena.