Publications (prior to the current position)
Publications (prior to the current position)
2015年
原著論文
Base pair recognition ability of 2-(methylamino)pyrimidin-4-yl nucleobase in parallel triplex DNA
Yoshiyuki Hari*, Satoshi Kashima, Yuya Matsuda, Akihiro Sakata, Ryutato Takamine, Shin Ijitsu, Satoshi Obika*
Heterocycles (Invited) 2015, 90, 432-441 (doi:10.3987/COM-14-S(K)41).
2014年
原著論文
Sulfonamide-bridged nucleic acid: Synthesis, High RNA selective hybridization, and high nuclease resistance
Yasunori Mitsuoka, Yuko Fujimura, Reiko Waki, Akira Kugimiya, Tsuyoshi Yamamoto, Yoshiyuki Hari, Satoshi Obika*
Org. Lett. 2014, 16, 5640-5643 (doi:10.1021/ol503029v).
Synthesis of oligonucleotides containing N,N-disubstituted 3-deazacytosine nucleobases by post-elongation modification and their triplex-forming ability with double-stranded DNA
Masaaki Akabane-Nakata, Satoshi Obika*, Yoshiyuki Hari*
Org. Biomol. Chem. 2014, 12, 9011-9015 (doi:10.1039/c4ob01760a).
Kinetic study of the binding of triplex-forming oligonucleotides containing partial cationic modifications to double-stranded DNA
Yoshiyuki Hari*, Shin Ijitsu, Masaaki Akabane-Nakata, Takuya Yoshida, Satoshi Obika*
Bioorg. Med. Chem. Lett. 2014, 24, 3046-3049 (doi:10.1016/j.bmcl.2014.05.031).
Guanidine bridged nucleic acid (GuNA): an effect of a cationic bridged nucleic acid on DNA binding affinity
Ajaya R. Shrestha, Yutaro Kotobuki, Yoshiyuki Hari, Satoshi Obika*
Chem. Commun. 2014, 50, 575-577 (doi:10.1039/c3cc46017g).
The ability of 1-aryltriazole-containing nucleobases to recognize a TA base pair in triplex DNA
Yoshiyuki Hari*, Motoi Nakahara, Shin Ijitsu, Satoshi Obika*
Heterocycles (Invited) 2014, 88, 377-386 (doi:10.3987/COM-13-S(S)33).
2013年
原著論文
2',4'-BNA bearing a chiral guanidinopyrrolidine-containing nucleobase with potent ability to recognize the CG base pair in parallel-motif DNA triplex
Yoshiyuki Hari*, Masaaki Akabane, Satoshi Obika*
Chem. Commun. 2013, 49, 7421-7423 (doi:10.1039/c3cc44030c).
Synthesis and properties of 2'-O,4'-C-ethyleneoxy bridged 5-methyluridine
Yoshiyuki Hari*, Tomohiko Morikawa, Takashi Osawa, Satoshi Obika*
Org. Lett. 2013, 15, 3702-3705 (doi:10.1021/ol401566r).
Synthesis of novel polyesteramine dendrimers by divergent and convergent methods
Hitoshi Akiyama, Kazuyuki Miyashita, Yoshiyuki Hari, Satoshi Obika*, Takeshi Imanishi
Tetrahedron 2013, 69, 6810-6820 (doi:10.1016/j.tet.2013.06.024).
Triplex-forming ability of oligonucleotides containing 1-aryl-1,2,3-triazole nucleobases linked via a two atom-length spacer
Yoshiyuki Hari*, Motoi Nakahara, Satoshi Obika*
Bioorg. Med. Chem. 2013, 21, 5583-5588 (doi:10.1016/j.bmc.2013.05.034).
Base-pair recognition ability of hydroxyphenyl nucleobases in parallel triplex DNA
Yoshiyuki Hari*, Satoshi Kashima, Hiroyasu Inohara, Shin Ijitsu, Takeshi Imanishi, Satoshi Obika*
Tetrahedron 2013, 69, 6381-6391 (doi:10.1016/j.tet.2013.05.107).
Synthesis and properties of thymidines with six-membered amide bridge
Yoshiyuki Hari, Takashi Osawa, Yutaro Kotobuki, Ajaya R. Shrestha, Aiko Yahara, Satoshi Obika*
Bioorg. Med. Chem. 2013, 21, 4405-4412 (doi:10.1016/j.bmc.2013.04.049).
総説
三重鎖核酸形成時に二重鎖DNA中のCG塩基対を認識可能な人工核酸の開発
張 功幸*
Yakugaku Zasshi (Invited) 2013, 133, 1201-1208 (doi:10.1248/yakushi.13-00215).
2012年
原著論文
A 2-amino-6-methylpyridin-5-yl nucleobase for GC base pair recognition in the parallel triplex DNA
Motoi Nakahara, Yoshiyuki Hari*, Satoshi Obika
Heterocycles (Invited) 2012, 86, 1135-1146 (doi:10.3987/COM-12-S(N)68).
Synthesis and duplex-forming ability of oligonucleotides containing 4’-carboxythymidine analogs
Yoshiyuki Hari, Takashi Osawa, Satoshi Obika*
Org. Biomol. Chem. (Invited) 2012, 10, 9639-9649 (doi:10.1039/c2ob26712h).
Amido-bridged nucleic acid (AmNA): Synthesis, duplex stability, nuclease resistance, and in vitro antisense potency
Aiko Yahara, Ajaya R. Shrestha, Tsuyoshi Yamamoto, Yoshiyuki Hari, Takashi Osawa, Masaki Yamaguchi, Masaru Nishida, Tetsuya Kodama, Satoshi Obika*
ChemBioChem 2012, 13, 2513-2516 (doi:10.1002/cbic.201200506).
総説
Towards the sequence-selective recognition of double-stranded DNA containing pyrimidine-purine interruptions by triplex-forming oligonucleotides
Yoshiyuki Hari*, Satoshi Obika, Takeshi Imanishi*
Eur. J. Org. Chem. (Invited) 2012, 2012, 2875-2887 (doi:10.1002/ejoc.201101821).
2011年
原著論文
Synthesis and properties of a bridged nucleic acid with a perhydro-1,2-oxazin-3-one ring
Ajaya R. Shrestha, Yoshiyuki Hari, Aiko Yahara, Takashi Osawa, Satoshi Obika*
J. Org. Chem. 2011, 76, 9891-9899 (doi:10.1021/jo201597e).
A 4-[(3R,4R)-dihydroxypyrrolidino]pyrimidin-2-one nucleobase for a CG base pair in triplex DNA
Yoshiyuki Hari*, Masaaki Akabane, Yuri Hatanaka, Motoi Nakahara, Satoshi Obika*
Chem. Commun. 2011, 47, 4424-4426 (doi:10.1039/c1cc10138b).
Synthesis and triplex-forming ability of oligonucleotides bearing 1-substituted 1H-1,2,3-triazole nucleobases
Yoshiyuki Hari*, Motoi Nakahara, Juanjuan Pang, Masaaki Akabane, Takeshi Kuboyama, Satoshi Obika*
Bioorg. Med. Chem. 2011, 19, 1162-1166 (doi:10.1016/j.bmc.2010.12.049).
洋書
2’-O,4’-C-Methyleneoxymethylene bridged nucleic acid (2’,4’-BNACOC)
Yoshiyuki Hari, Tetsuya Kodama, Takeshi Imanishi, Satoshi Obika
Therapeutic Oligonucleotides, J. Goodchild (ed.), Humana Press, 31-57 (2011).
1-Diazo-1-silylalkanes (Update 2010)
Yoshiyuki Hari, Toyohiko Aoyama, Takayuki Shioiri
Science of Synthesis Knowledge Updates 2010/4, M. Oestreich (vol ed.), Georg Thieme Verlag, 325-68 (2011).
2010年
原著論文
Facile synthesis of 1-methyl-1H-benzo[b]azepines from 1-methylquinolinium iodides and diazo(trimethylsilyl)methylmagnesium bromide
Mikio Morita, Yoshiyuki Hari*, Toyohiko Aoyama
Synthesis 2010, 4221-4227 (doi:10.1055/s-0030-1258306).
2’,4’-BNA bearing a 2-pyridine nucleobase for CG base pair recognition in the parallel motif triplex DNA
Yoshiyuki Hari*, Sachiko Matsugu, Hiroyasu Inohara, Yuri Hatanaka, Masaaki Akabane, Takeshi Imanishi, Satoshi Obika*
Org. Biomol. Chem. 2010, 8, 4176-4180 (doi:10.1039/c004895j).
Synthesis of 3-substituted 3-(trimethylsilyl)pyrrolidines from β-aminoketones and lithium trimethylsilyldiazomethane
Yoshiyuki Hari, Takuya Yokoyama, Toyohiko Aoyama*
Heterocycles (Invited) 2010, 80, 679-687 (doi:10.3987/COM-09-S(S)70).
2009年
原著論文
Facile synthesis of 2-unsubstituted benzofuran-3-carboxylates using diazo(trimethylsilyl)methylmagnesium bromide
Yoshiyuki Hari*, Ryosuke Kondo, Koji Date, Toyohiko Aoyama*
Tetrahedron 2009, 65, 8708-8713 (doi:10.1016/j.tet.2009.08.041).
The effects of unnatural base pairs and mispairs on DNA duplex stability and solvation
Gil Tae Hwang, Yoshiyuki Hari, Floyd E. Romesberg*
Nucleic Acids Res. 2009, 37, 4757-4763 (doi:10.1093/nar/gkp467).
Facile two-step synthesis of 3-substituted indazoles using diazo(trimethylsilyl)methylmagnesium bromide
Yoshiyuki Hari*, Ryosuke Sone, Toyohiko Aoyama*
Org. Biomol. Chem. 2009, 7, 2804-2808 (doi:10.1039/b907796k).
Synthesis and base-pairing properties of C-nucleotides having 1-substituted 1H-1,2,3-triazoles
Motoi Nakahara, Takeshi Kuboyama, Akihiro Izawa, Yoshiyuki Hari*, Takeshi Imanishi, Satoshi Obika*
Bioorg. Med. Chem. Lett. 2009, 19, 3316-3319 (doi:10.1016/j.bmcl.2009.04.063).
A bridged nucleic acid, 2’,4’-BNACOC: Synthesis of fully modified oligonucleotides bearing thymine, 5-methylcytosine, adenine and guanine 2’,4’-BNACOC monomers and RNA-selective nucleic-acid recognition
Yasunori Mitsuoka, Tetsuya Kodama, Ryo Ohnishi, Yoshiyuki Hari, Takeshi Imanishi, Satoshi Obika*
Nucleic Acids Res. 2009, 37, 1225-1238 (doi:10.1093/nar/gkn1062).
総説
トリメチルシリルジアゾメタンを用いる複素環化合物の合成
張 功幸*，塩入孝之，青山豊彦*
J. Synth. Org. Chem., Jpn. (Invited) 2009, 67, 357-368 (doi:10.5059/yukigoseikyokaishi.67.357).
2008年
原著論文
Optimization of the pyridyl nucleobase scaffold for polymerase recognition and unnatural base pair replication
Yoshiyuki Hari, Gil Tae Hwang, Aaron M. Leconte, Nicolas Joubert, Michal Hocek, Floyd E. Romesberg*
ChemBioChem 2008, 9, 2796-2799 (doi:10.1002/cbic.200800577).
New synthesis of t-butyl arylpropiolates using diazo(trimethylsilyl)methylmagnesium bromide
Yoshiyuki Hari, Koji Date, Ryosuke Kondo, Toyohiko Aoyama*
Tetrahedron Lett. 2008, 49, 4965-4967 (doi:10.1016/j.tetlet.2008.05.155).
Synthesis of chiral tetrahydroisoquinoline-derived b-amino alcohols and their application to asymmetric reaction
Yoshiyuki Hari, Masaki Sakuma, Ayako Miyakawa, Keiichiro Hatano, Toyohiko Aoyama*
Heterocycles (Invited) 2008, 76, 305-311 (doi:10.3987/COM-08-S(N)9).
Discovery, characterization, and optimization of an unnatural base pair for expansion of the genetic alphabet
Aaron M. Leconte, Gil Tae Hwang, Shigeo Matsuda, Petr Capek, Yoshiyuki Hari, Floyd E. Romesberg*
J. Am. Chem. Soc. 2008, 130, 2336-2343 (doi:10.1021/ja078223d).
Recognition of T•A interruption by 2',4'-BNAs bearing heteroaromatic nucleobases through parallel motif triplex formation
Satoshi Obika, Hiroyasu Inohara, Yoshiyuki Hari, Takeshi Imanishi*
Bioorg. Med. Chem. 2008, 16, 2955-2967 (doi:10.1016/j.bmc.2007.12.043).
Facile synthesis of 2-azaazulenes from thiobenzoyl isocyanates using trimethylsilyldiazomethane
Mikio Morita, Yoshiyuki Hari, Tomoe Iguchi, Toyohiko Aoyama*
Tetrahedron 2008, 64, 1753-1758 (doi:10.1016/j.tet.2007.11.107).
2007年
原著論文
Facile one-pot synthesis of functionalized acetylenes from aryl and heteroaryl aldehydes using lithium trimethylsilyldiazomethane
Yoshiyuki Hari, Koji Date, Toyohiko Aoyama*
Heterocycles (Invited) 2007, 74, 545-552 (doi:10.3987/COM-07-S(W)32).
An efficient synthesis of 2-diazo-2-(trimethylsilyl)ethanols and their application to pyrazole synthesis
Yoshiyuki Hari, Susumu Tsuchida, Ryosuke Sone, Toyohiko Aoyama*
Synthesis 2007, 3371-3375 (doi:10.1055/s-2007-990817).
2006年
原著論文
Stability and polymerase recognition of pyridine nucleobase analogues: Role of minor-groove H-bond acceptors
Yoonkyung Kim, Aaron M. Leconte, Yoshiyuki Hari, Floyd E. Romesberg*
Angew. Chem. Int. Ed. 2006, 45, 7809-7812 (doi:10.1002/ange.200602579).
One-pot, cis-selective synthesis of α-substituted β-trimethylsilyl-α,β-epoxyesters from α-ketoesters and diazo(trimethylsilyl)methylmagnesium bromide
Yoshiyuki Hari, Susumu Tsuchida, Toyohiko Aoyama*
Tetrahedron Lett. 2006, 47, 1977-1980 (doi:10.1016/j.tetlet.2006.01.067).
Efficient synthesis of o-alkynyl-N-pivaloylanilines from o-acyl-N-pivaloylanilines and lithium trimethylsilyldiazomethane
Yoshiyuki Hari, Tomoki Kanie, Toyohiko Aoyama*
Tetrahedron Lett. 2006, 47, 1137-1139 (doi:10.1016/j.tetlet.2005.12.051).
One-pot synthesis of 2,3-disubstituted N-tosylindoles from o-acyl-N-tosylanilines
Yoshiyuki Hari, Tomoki Kanie, Takashi Miyagi, Toyohiko Aoyama*
Synthesis 2006, 1249-1252 (doi:10.1055/s-2006-926398).
Synthesis and properties of 2’-O,4’-C-methyleneoxymethylene bridged nucleic acid
Yoshiyuki Hari, Satoshi Obika, Ryo Ohnishi, Ken Eguchi, Tomohisa Osaki, Hirofumi Ohishi, Takeshi Imanishi*
Bioorg. Med. Chem. 2006, 14, 1029-1038 (doi:10.1016/j.bmc.2005.09.020).
その他
アキラルリガンドの添加による不斉反応の改良
張 功幸
ファルマシア, 42, 470-471 (2006).
2005年
原著論文
New synthesis of t-butyl 1,2-dihydro-1-oxaazulene-3-carboxylates using lithium trimethylsilyldiazomethane
Susumu Tsuchida, Yoshiyuki Hari, Toyohiko Aoyama*
Heterocycles 2005, 65, 2667-2674 (doi:10.3987/COM-05-10504).
Facile, one-pot synthesis of bicyclic 2-pyridones from acyl isocyanates, N-phenylmaleimide and trimethylsilyldiazomethane
Yoshiyuki Hari, Tomoe Iguchi, Toyohiko Aoyama*
Synthesis 2005, 2147-2150 (doi:10.1055/s-2005-870002).
Synthesis and triplex-forming ability of 2’,4’-BNAs bearing imidazoles as a nucleobase
Yoshiyuki Hari, Satoshi Obika, Hiroyasu Inohara, Masahiro Ikejiri, Daisuke Une, Takeshi Imanishi*
Chem. Pharm. Bull. 2005, 53, 843-846 (doi:10.1248/cpb.53.843).
Regioselective synthesis of 1-arylindazoles via N-arylation of 3-trimethylsilylindazoles
Yoshiyuki Hari, Yoshimichi Shoji, Toyohiko Aoyama*
Tetrahedron Lett. 2005, 46, 3771-3774 (doi:10.1016/j.tetlet.2005.03.157).
Enantioselective addition of diethylzinc to aldehydes catalyzed by (1R,2R)-10-(dialkylamino)isoborneols
Yoshiyuki Hari, Toyohiko Aoyama*
Synthesis 2005, 583-587 (doi:10.1055/s-2005-861788).
2004年
原著論文
New synthesis of 3-substituted indoles using lithium trimethylsilyldiazomethane
Takashi Miyagi, Yoshiyuki Hari, Toyohiko Aoyama*
Tetrahedron Lett. 2004, 45, 6303-6305 (doi:10.1016/j.tetlet.2004.06.102).
Facile one-pot synthesis of di- and tri-substituted furans from acyl isocyanates using trimethylsilyldiazomethane
Yoshiyuki Hari, Tomoe Iguchi, Toyohiko Aoyama*
Synthesis 2004, 1359-1362 (doi:10.1055/s-2004-822397).
New synthesis of 3-substituted indazoles from 3-trimethylsilylindazole
Yoshiyuki Hari, Yoshimichi Shoji, Toyohiko Aoyama*
Synthesis 2004, 1183-1186 (doi:10.1055/s-2004-822351).
Facile synthesis of 3-trimethylsilylindazoles by [3+2]cycloaddition reaction of lithium trimethylsilyldiazomethane with benzynes
Yoshimichi Shoji, Yoshiyuki Hari, Toyohiko Aoyama*
Tetrahedron Lett. 2004, 45, 1769-1771 (doi:10.1016/j.tetlet.2003.12.086).
2003年
原著論文
New two-step synthesis of azulene-1-carboxylic esters using lithium trimethylsilyldiazomethane
Yoshiyuki Hari, Shunkichi Tanaka, Yasuta Takuma, Toyohiko Aoyama*
Synlett 2003, 2151-2154 (doi:10.1055/s-2003-42064).
Selective recognition of CG interruption by 2’,4’-BNA having 1-isoquinolone as a nucleobase in a pyrimidine motif triplex formation
Yoshiyuki Hari, Satoshi Obika, Mitsuaki Sekiguchi, Takeshi Imanishi*
Tetrahedron 2003, 59, 5123-5128 (doi:10.1016/S0040-4020(03)00728-2).
Synthesis and properties of a novel bridged nucleic acid with a P3’→N5’ phosphoramidate linkage, 5’-amino-2’,4’-BNA
Satoshi Obika, Osamu Nakagawa, Akiko Hiroto, Yoshiyuki Hari, Takeshi Imanishi*
Chem. Commun. 2003, 2202-2203 (doi:10.1039/B307290H).
Triplex formation involving 2’-O,4’-C-methylene bridged nucleic acid (2’,4’-BNA) with 1-isoquinolone base analogue: Efficient and selective recognition of C:G interruption
Hidetaka Torigoe*, Yoshiyuki Hari, Satoshi Obika, Takeshi Imanishi*
Nucleos. Nucleot. Nucleic Acids 2003, 22, 1571-1573 (doi:10.1081/NCN-120023036).
Triplex formation involving 2’-O,4’-C-methylene bridged nucleic acid (2’,4’-BNA) with 2-pyridone base analogue: Efficient and selective recognition of C:G interruption
Hidetaka Torigoe*, Yoshiyuki Hari, Satoshi Obika, Takeshi Imanishi*
Nucleos. Nucleot. Nucleic Acids 2003, 22, 1097-1099 (doi:10.1081/NCN-120022745).
その他
キラルジオキシランを用いたα,β-不飽和エステルの不斉エポキシ化反応
張 功幸
ファルマシア, 39, 447-448 (2003).
2002年
原著論文
Stable oligonucleotide-directed triplex formation at target sites with CG interruptions: Strong sequence-specific recognition by 2’,4’-bridged nucleic acid containing 2-pyridones under physiological conditions
Satoshi Obika, Yoshiyuki Hari, Mitsuaki Sekiguchi, Takeshi Imanishi*
Chem. Eur. J. 2002, 8, 4796-4802 (doi:10.1002/1521-3765(20021018)8:20<4796::AID-CHEM4796>3.0.CO;2-O).
Synthesis and conformation of a novel bridged nucleoside with S-type sugar puckering, trans-3’,4’-BNA monomer
Satoshi Obika, Mitsuaki Sekiguchi, Tomohisa Osaki, Nao Shibata, Miyuki Masaki, Yoshiyuki Hari, Takeshi Imanishi*
Tetrahedron Lett. 2002, 43, 4365-4368 (doi:10.1016/S0040-4039(02)00784-0).
Effective synthesis of C-nucleosides with 2’,4’-BNA modification
Yoshiyuki Hari, Satoshi Obika, Minako Sakaki, Ken-ichiro Morio, Yuriko Yamagata, Takeshi Imanishi*
Tetrahedron 2002, 58, 3051-3063 (doi:10.1016/S0040-4020(02)00226-0).
Synthesis and conformation of 3’,4’-BNA monomers, 3’-O,4’-C-methyleneribonucleosides
Satoshi Obika, Ken-ichiro Morio, Daishu Nanbu, Yoshiyuki Hari, Hiromi Itoh, Takeshi Imanishi*
Tetrahedron 2002, 58, 3039-3049 (doi:10.1016/S0040-4020(02)00227-2).
その他
超機能性人工核酸の開発に向けて
今西 武，張 功幸
脳21, 5, 309-314 (2002).
2001年
原著論文
2’-O,4’-C-Methylene bridged nucleic acid modification promotes pyrimidine motif triplex DNA formation at physiological pH: Thermodynamic and kinetic studies
Hidetaka Torigoe*, Yoshiyuki Hari, Mitsuaki Sekiguchi, Satoshi Obika, Takeshi Imanishi*
J. Biol. Chem. 2001, 276, 2354-2360 (doi:10.1074/jbc.M007783200).
A 2’,4’-bridged nucleic acid containing 2-pyridone as a nucleobase: Efficient recognition of a C･G interruption by triplex formation with a pyrimidine motif
Satoshi Obika, Yoshiyuki Hari, Mitsuaki Sekiguchi, Takeshi Imanishi*
Angew. Chem. Int. Ed. 2001, 40, 2079-2081 (doi:10.1002/1521-3773(20010601)40:11<2079::AID-ANIE2079>3.0.CO;2-Z).
2000年
原著論文
Triplex-forming enhancement with high sequence selectivity by single 2’-O,4’-C-methylene bridged nucleic acid (2’,4’-BNA) modification
Satoshi Obika, Yoshiyuki Hari, Tomomi Sugimoto, Mitsuaki Sekiguchi, Takeshi Imanishi*
Tetrahedron Lett. 2000, 41, 8923-8927 (doi:10.1016/S0040-4039(00)01607-5).
Triplex formation by an oligonucleotide containing conformationally locked C-nucleoside, 5-(2-O,4-C-methylene-β-D-ribofuranosyl)oxazole
Satoshi Obika, Yoshiyuki Hari, Ken-ichiro Morio, Takeshi Imanishi*
Tetrahedron Lett. 2000, 41, 221-224 (doi:10.1016/S0040-4039(99)02052-3).
Synthesis of conformationally locked C-nucleosides having a 2,5-dioxabicyclo[2.2.1]heptane ring system
Satoshi Obika, Yoshiyuki Hari, Ken-ichiro Morio, Takeshi Imanishi*
Tetrahedron Lett. 2000, 41, 215-219 (doi:10.1016/S0040-4039(99)01998-X).
1999年
原著論文
Preparation and properties of 2’,5’-linked oligonucleotide analogues containing 3’-O,4’-C-methyleneribonucleosides
Satoshi Obika, Ken-ichiro Morio, Yoshiyuki Hari, Takeshi Imanishi*
Bioorg. Med. Chem. Lett. 1999, 9, 515-518 (doi:10.1016/S0960-894X(99)00028-1).
Facile synthesis and conformation of 3’-O,4’-C-methyleneribonucleosides
Satoshi Obika, Ken-ichiro Morio, Yoshiyuki Hari, Takeshi Imanishi*
Chem. Commun. 1999, 2423-2424 (doi:0.1039/A907218G).
1998年
原著論文
Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2’-O,4’-C-methyleneribonucleosides
Satoshi Obika, Daishu Nanbu, Yoshiyuki Hari, Jun-ichi Andoh, Ken-ichiro Morio, Takefumi Doi, Takeshi Imanishi*
Tetrahedron Lett. 1998, 39, 5401-5404 (doi:10.1016/S0040-4039(98)01084-3).
1997年
原著論文
Synthesis of 2’-O,4’-C-methyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed C3’-endo sugar puckering
Satoshi Obika, Daishu Nanbu, Yoshiyuki Hari, Ken-ichiro Morio, Yasuko In, Toshimasa Ishida, Takeshi Imanishi*
Tetrahedron Lett. 1997, 38, 8735-8738 (doi:10.1016/S0040-4039(97)10322-7).
2020年
原著論文
Synthesis of Pyrazoles Utilizing the Ambiphilic Reactivity of Hydrazones
Haruo Matsuzaki, Norihiko Takeda, Motohiro Yasui, Yuta Ito, Keiji Konishi, Masafumi Ueda*
Org. Lett. 2020, 22, 9249–9252 (doi: 10.1021/acs.orglett.0c03465).
2016年
原著論文
tert-Butyl Iodide Mediated Reductive Fischer Indolization of Conjugated Hydrazones
Yuta Ito, Masafumi Ueda*, Norihiko Takeda, Okiko Miyata*
Chem. Eur. J. 2016, 22, 2616-2619 (doi: 10.1002/chem.201504010).
Highlighted in Synfacts (issue 05/2016).
2015年
学会発表
ヨウ化水素の特性を利用した共役ヒドラゾンの還元反応の開発とインドール合成への応用
○伊藤勇太, 上田昌史, 武田紀彦, 宮田興子
第41回反応と合成の進歩シンポジウム, 2015年10月27日 (近畿大学 11月ホール).
ヨウ化t-ブチルを酸及び還元剤として利用した新規インドール合成法の開発
○伊藤勇太, 上田昌史, 武田紀彦, 宮田興子
第35回有機合成若手セミナー, 2015年8月1日 (京都府立大学 下鴨キャンパス).
Alkylative and Reductive Fischer Indolization of Conjugated Hydrazones
○Yuta Ito, Masafumi Ueda, Norihiko Takeda, Okiko Miyata
7th Pacific Symposium on Radical Chemistry (PSRC-7), 2015年7月16日 (Nanyang Technological University).
共役ヒドラゾンを基質とする新規インドール合成法の開発
○伊藤勇太, 上田昌史, 武田紀彦, 宮田興子
日本薬学会第135年会, 2015年3月26日 (神戸学院大学 ポートアイランドキャンパス).
2014年
原著論文
Sequential Radical Addition and Fischer-type Indolization Reactions of Conjugated Hydrazones for the Preparation of α-Alkylindole-3-acetic Acids
Yuta Ito, Masafumi Ueda*, Naomi Matsuda, Yuika Nishida, Okiko Miyata*
Heterocycles 2014, 89, 963-969 (doi: 10.3987/COM-14-12957).
Direct Synthesis of Benzofuro[2,3-b]pyrroles through a Radical Addition/[3,3]-Sigmatropic Rearrangement/Cyclization/Lactamization Cascade
Masafumi Ueda, Yuta Ito, Yuki Ichii, Maiko Kakiuchi, Hiroko Shono, Okiko Miyata*
Chem. Eur. J. 2014, 20, 6763-6770 (doi: 10.1002/chem.201402217).
総説
Synthetic Routes towards Benzofuro[2,3-b]pyrroles and Benzofuro[2,3-b]indoles
Yuta Ito, Masafumi Ueda*, Okiko Miyata*
Heterocycles 2014, 89, 2029-2052 (doi: 10.3987/REV-14-798).
学会発表
Direct Synthesis of Benzofuro[2,3-b]pyrroles by a Domino Reaction Involving a Radical Addition and [3,3]-Sigmatropic Rearrangement
Masafumi Ueda, ○Yuta Ito, Okiko Miyata
20th International Conference on Organic Synthesis (ICOS-20), 2014年7月1-2日 (ELTE Convention Centre).
ラジカル付加反応と[3,3]-シグマトロピー転位が連動する新規ドミノ型反応の開発
○伊藤勇太, 上田昌史, 宮田興子
第12回次世代を担う有機化学シンポジウム, 2014年5月23日 (日本薬学会長井記念ホール).
ラジカル付加反応とFischer型インドール合成が連続するドミノ型反応の開発
上田昌史, ○伊藤勇太, 松田奈央美, 三好哲也, 宮田興子
日本薬学会第134年会, 2014年3月28日 (熊本大学 黒髪キャンパス).
2013年
学会発表
ベンゾフロ[2,3-b]ピロール骨格の効率的合成法の開発
○上田昌史, 伊藤勇太, 三好哲也, 宮田興子
第31回メディシナルケミストリーシンポジウム, 2013年11月20日 (アステールプラザ).
ドミノ型ラジカル付加－転位反応を利用したベンゾフロ[2,3-b]ピロールの合成
上田昌史, ○伊藤勇太, 三好哲也, 宮田興子
第43回複素環化学討論会, 2013年10月17日 (長良川国際会議場).
ラジカル付加反応を基盤とする新規ドミノ型反応を利用したインドール合成法の開発
上田昌史, 伊藤勇太, ○松田奈央美, 三好哲也, 松野研司, 宮田興子
第63回日本薬学会近畿支部総会・大会, 2013年10月12日 (同志社大学 京田辺キャンパス).
2012年
学会発表
ラジカル付加反応と[3,3]-シグマトロピー転位が連動する立体選択的ドミノ型反応の開発
上田昌史, ○伊藤勇太, 三好哲也, 宮田興子
第32回有機合成若手セミナー, 2012年11月22日 (神戸薬科大学 ききょう記念ホール).
Novel Domino Reaction Involving a Radical Addition/[3,3]-Sigmatropic Rearrangement/Cyclization/Lactamization
Masafumi Ueda, ○Yuta Ito, Tetsuya Miyoshi, Okiko Miyata
The 12th International Kyoto Conference on New Aspect of Organic Chemistry (IKCOC-12), 2012年11月14日 (リーガロイヤルホテル京都).
立体選択的ラジカル付加反応と[3,3]-シグマトロピー転位反応が連動する新規ドミノ型反応の開発
上田昌史, ○伊藤勇太, 一井裕妃, 垣内麻衣子, 庄野裕子, 三好哲也, 宮田興子
日本薬学会第132年会, 2012年3月31日 (北海道大学 札幌キャンパス).
2011年
原著論文
Benzyl Radical Addition Reaction through the Homolytic Cleavage of a Benzylic C-H Bond
Masafumi Ueda, Eiko Kondoh, Yuta Ito, Hiroko Shono, Maiko Kakiuchi, Yuki Ichii, Takahiro Kimura, Tetsuya Miyoshi, Takeaki Naito, Okiko Miyata*
Org. Biomol. Chem. 2011, 9, 2062-2064 (doi: 10.1039/c0ob01148g).
Silver-Catalyzed Synthesis of Disubstituted Isoxazoles by Cyclization of Alkynyl Oxime Ethers
Masafumi Ueda, Yuki Ikeda, Aoi Sato, Yuta Ito, Maiko Kakiuchi, Hiroko Shono, Tetsuya Miyoshi, Takeaki Naito, Okiko Miyata*
Tetrahedron 2011, 67, 4612-4615 (doi: 10.1016/j.tet.2011.04.083).
Palladium-Catalyzed Cross Coupling Reaction of N-Alkoxyimidoyl Bromides and Its Application to One-pot Synthesis of N-Arylamines
Masafumi Ueda, Shoichi Sugita, Naoki Aoi, Aoi Sato, Yuki Ikeda, Yuta Ito, Tetsuya Miyoshi, Takeaki Naito, Okiko Miyata*
Chem. Pharm. Bull. 2011, 59, 1206-1208 (doi: 10.1248/cpb.59.1206).
学会発表
ラジカル付加反応と[3,3]-シグマトロピー転位反応が連動する新規ドミノ型反応の開発
上田昌史, ○垣内麻衣子, 一井裕妃, 伊藤勇太, 庄野裕子, 三好哲也, 宮田興子
第31回有機合成若手セミナー, 2011年11月16日 (京都大学 人間・環境学研究科棟 地階大講義室).
ラジカル付加反応と[3,3]-シグマトロピー転位反応が連動する新規ドミノ型反応の開発
上田昌史, ○伊藤勇太, 一井裕妃, 垣内麻衣子, 庄野裕子, 三好哲也, 宮田興子
第61回日本薬学会近畿支部総会・大会, 2011年10月22日 (神戸学院大学 ポートアイランドキャンパス).
Synthesis of Benzofuro[2,3-b]pyrroles through a Radical Addition/[3,3]-Sigmatropic Rearrangement/Cyclization/Lactamization Cascade
○Masafumi Ueda, Yuta Ito, Okiko Miyata
5th Pacific Symposium on Radical Chemistry (PSRC-5), 2011年9月25-26日 (ホテルシーモア).
ラジカル付加反応と[3,3]－シグマトロピー転位反応を組み合わせた新規ドミノ型反応の開発
○上田昌史, 垣内麻衣子, 一井裕妃, 伊藤勇太, 庄野裕子, 三好哲也, 宮田興子
日本薬学会第131年会, 2011年3月31日 (ツインメッセ静岡).
2021年
原著論文
Artificial Host Molecules to Covalently Capture 8‑Nitro-cGMP inNeutral Aqueous Solutions and in Cells
Yasufumi Fuchi,Hirotaka Murase, Ryosuke Kai, Kakeru Kurata, Satoru Karasawa, Shigeki Sasaki*
Bioconjugate Chem. 2021, 32, 385-393 (doi:10.1021/acs.bioconjchem.1c00012).
Push–Pull Bisnaphthyridylamine Supramolecular Nanoparticles: Polarity‐Induced Aggregation‐ and Crystallization‐Induced Emission Enhancement and Fluorescence Resonance Energy Transfer
Ryusuke Hagihara, Tomohiro Umeno, Shoji Ueki, Daisuke Yoshihara, Yasufumi Fuchi, Kazuteru Usui, Masaomi Sakuma, Ken-ichi Yamada, Satoru Karasawa*
Chem. Eur. J. 2021, 27, 3039-3046 (doi:10.1002/chem.202003854).
2020年
原著論文
Characterization of Push–Pull-Type Benzo[X]quinoline Derivatives (X = g or f): Environmentally Responsive Fluorescent Dyes with Multiple Functions
Yasufumi Fuchi,* Tomohiro Umeno, Yuichiro Abe, Keita Ikeno, Ryu Yamasaki, Iwao Okamoto, Kazuteru Usui,* Satoru Karasawa*
J. Org. Chem. 2020, 85, 13177–13190 (doi:10.1021/acs.joc.0c01878). (Supplementary Cover).
A fully synthetic 6-aza-artemisinin bearing an amphiphilic chain generates aggregates and exhibits anti-cancer activities
Hikari Koi, Norihito Takahashi, Yasufumi Fuchi, Tomohiro Umeno, Yukiko Muramatsu, Hiroyuki Seimiya, Satoru Karasawa*, Hiroki Oguri*
Org. Biomol. Chem. 2020, 18, 5339-5343.
Characterization and Water-Proton Longitudinal Relaxivities of Liposome-Type Radical Nanoparticles Prepared via a Supramolecular Approach
Ryoma Shiraishi, Shota Matsumoto, Yasufumi Fuchi, Tatsuya Naganuma, Daisuke Yoshihara, Kazuteru Usui, Ken-ichi Yamada, Satoru Karasawa*
Langmuir 2020, 36, 5280–5286.
2019年
原著論文
Effects of substituents on the properties of metal-free MRI contrast agents
Shigeki Kobayashi, Yasufumi Fuchi, Yuta Matsuoka, Go Hirai, Ken-ichi Yamada, Satoru Karasawa*
ACS. Omega 2019, 4, 20715-20723 (doi: 10.1021/acsomega.9b03003).
Selective synthesis of substituted amino-quinoline derivatives by C-H activation and fluorescence evaluation of their lipophilicity- responsive properties
Yasufumi Fuchi*, Masaomi Sakuma, Kohei Ohyama, Ryusuke Hagihara, Minaki Kohno, Koichi Hamada, Akihiro Mizutani, Satoru Karasawa*
Sci. Rep. 2019, 9:17723, 1-9 (doi: 10.1038/s41598-019-53882-z).
Photophysical properties of emissive pyrido[3,2-c]carbazole derivatives and apoptosis induction: Development towards theranostic
Masaomi Sakuma, Yasufumi Fuchi*, Kazuteru Usui, Satoru Karasawa*
Chem. Asian. J. 2019, 14, 3938-3945 (doi: 10.1002/asia.201901200).
Fluorescence properties and exciplex formation of emissive naphthyridine derivatives: Application as sensors for amines
Junko Hirota, KazuteruUsui, YasufumiFuchi, Masaomi Sakuma, Shota Matsumoto, Ryusuke Hagihara, Satoru Karasawa*
Chem. Eur. J. 2019, 25, 14943-14952 (doi: 10.1002/chem.201903643).
Development of turn-on probes for acids triggered by aromaticity enhancement using tricyclic amidine derivatives
Shota Matsumoto, Yasufumi Fuchi, Kazuteru Usui, Go Hirai, Satoru Karasawa*
J. Org. Chem. 2019, 84, 6612-6622 (doi: 10.1021/acs.joc.9b00023).
その他
近赤外発光団を導入した蛍光プローブによる生理活性化合物の探索
渕 靖史
ぶんせき 2019, 524.
2018年
原著論文
Fluorescence tumor-imaging using a thermo-responsive molecule with an emissive aminoquinoline derivatives
Takeru Araki, Yasufumi Fuchi, Shuhei Murayama, Ryoma Shiraishi, Tokimi Oyama, Mariko Aso, Ichio Aoki, Shigeki Kobayashi, Ken-ichi Yamada, Satoru Karasawa*
Nanomaterials 2018, 8, 782 (doi: 10.3390/nano8100782).
Self-assembled biradical ureabenzene nanoparticles for magnetic resonance imaging
Kosuke Morishita, Shoji Ueki, Yasufumi Fuchi, Shuhei Murayama, Tomoyo Kaneko, Nozomi Narita, Shigeki Kobayashi, Go Hirai, Ichi Aoki, Satoru Karasawa*
ACS Appl. Nano Mater. 2018, 1, 6967-6975 (doi: 10.1021/acsanm.8b01774).
Effect of hydrophobicity on the self-assembly behavior of urea benzene derivatives in aqueous solution
Yuna Okamoto, Kosuke Morishita, Yasufumi Fuchi, Shigeki Kobayashi, Satoru Karasawa*
Appl. Sci. 2018, 8, 1080 (doi: 10.3390/app8071080).
Luminescent europium sensors for specific detection of 8-oxo-dGTP by time-gated fluorescence
Yasufumi Fuchi, Takashi Fukuda, Shigeki Sasaki*
Bioorg. Med. Chem. 2018, 26, 3254-3260 (doi: 10.1016/j.bmc.2018.04.052).
2016年
原著論文
Synthetic receptor molecules for selective fluorescent detection of 8-oxo-dGTP in aqueous media
Yasufumi Fuchi, Takashi Fukuda, Shigeki Sasaki*
Org. Biomol. Chem. 2016, 14, 7949-7955 (doi: 10.1039/C6OB01485B).
その他
化学反応性を獲得した核酸－酸化的に化学修飾されたグアノシン誘導体
渕 靖史
月刊化学 2016, 71, 70-71.
2015年
原著論文
New nitroG-Grasp molecules with enhanced capture reactivity for 8-nitroguanosine in the aqueous media
Yasufumi Fuchi, Shigeki Sasaki*
Chem. Pharm. Bull. 2015, 63, 913-919 (doi: 10.1248/cpb.c15-00550).
Development of new 1,3-diazaphenoxazine derivatives (ThioG-Grasp) to covalently capture 8-thioguanosine
Yasufumi Fuchi, Hideto Ohbayashi, Shigeki Sasaki*
Molecules 2015, 20, 1078-1087 (doi: 10.3390/molecules20011078).
2014年
原著論文
Efficient covalent capture of 8-nitroguanosine via a multiple hydrogen-bonded
Yasufumi Fuchi, Shigeki Sasaki*
Org. Lett. 2014, 16, 1760-1763 (doi: 10.1021/ol500452r).
2011年
原著論文
Optimization of fluorescence property of the 8-oxodGclamp derivative for better selectivity for 8-oxo-2'-deoxyguanosine
Yohei Koga, Yasufumi Fuchi, Osamu Nakagawa, Shigeki Sasaki*
Tetrahedron 2011, 67, 6746-6752 (doi: 10.1016/j/.tet.2011.03.111).
2010年
原著論文
Novel benzofurans with 99mTc complexes as probes for imaging cerebral β-amyloid plaques
Masahiro Ono, Yasufumi Fuchi, Takeshi Fuchigami, Nobuya Kobashi, Hiroyuki Kimura, Mamoru Haratake, Hideo Saji, Morio Nakayama
ACS Med. Chem. Lett. 2010, 1, 443–447 (doi: 10.1021/ml100140d).