Applying our novel temporally decoupled squared Wasserstein-2 method to reconstruct an SDE: dX = (5-X)dt + c_0 \sqrt{X}dB_t. X(t) (black): ground truth trajectories; \hat{X}(t) (red): reconstructed trajectories.
I am working on developing efficient Wasserstein-distance-based machine-learning algorithms for uncertainty quantification tasks. My recent work lies in two directions: i) reconstructing certain types of stochastic differential equations (SDEs) from time-series data, with applications in understanding noisy cellular dynamics and analyzing stock price dynamics and ii) quantifying extrinsic noise, i.e., reconstructing the distribution of unknown model parameters from observed data.
Cell density (number of cells) in a size- and generation-structured population (cell density n(x; i) characterized by cells' sizes x and generation i (the number of divisions a cell has gone through)).
After extracting dynamics from time-series data, kinetic modeling, which links individuals' behavior with macroscopic quantities, is required to understand population-level dynamics. I work on applying kinetic theories to build rigorous mathematical models for describing population dynamics to study how individuals' behavior would influence population dynamics, with applications in biology, ecology, and economics. Also, I work on controlling structured population dynamics with applications in controlling disease spread in social networks.
Applying the adaptive spectral method for solving a Schrödinger equation in the unbounded domain: very high accuracy could be achieved compared to non-adaptive spectral methods.
Equations that describe population dynamics in biophysics are sometimes defined in unbounded domains to track quantities whose scales span across different magnitudes. Thus, those quantities sometimes require tracking in unbounded domains. We developed a novel adaptive spectral method to efficiently solve unbounded-domain spatiotemporal equations for simulating population dynamics. My adaptive spectral method finds wide applications in other fields such as quantum mechanics and material science.
Publications (*: corresponding author)
2025
Journal of Computational Physics, 520, 113492, (2025)
2024
Kinetic theories of state- and generation-dependent cell populations
Physics Review E, 110, 064146, (2024)
Machine Learning: Science and Technology, 5, 045052, (2024)
Physica D: Nonlinear Phenomena, 470, 134339, (2024)
Solar wind structures from the Gaussianity of magnetic magnitude
The Astrophysical Journal Letters, 973, L26, (2024)
Learning unbounded-domain spatiotemporal differential equations using adaptive spectral methods
Journal of Applied Mathematics and Computing, 70, 4395–4421, (2024)
2023
The Innovation, 4, 100517, (2023)
Tom Chou, Sihong Shao, Mingtao Xia*
Adaptive Hermite spectral methods in unbounded domains
Applied Numerical Mathematics, 183, 201-220, (2023)
Spectrally adapted physics-informed neural networks for solving unbounded domain problems
Machine Learning: Science and Technology, 4, 025024, (2023)
2022
Frontiers in Immunology, 17, (2022)
Controlling epidemics through optimal allocation of test kits and vaccine doses across networks
IEEE Transactions on Network Science and Engineering, 9, 1422--1436, (2022)
2021
Environmental Science & Technology, 56, 7337-7349, (2021)
A frequency-dependent p-adaptive technique for spectral methods
Journal of Computational Physics, 446, 110627, (2021)
Efficient scaling and moving techniques for spectral methods in unbounded domains
SIAM Journal on Scientific Computing, 43, A3244-A3268, (2021)
Kinetic theory for structured populations
Journal of Physics A: Mathematical and Theoretical, 54, 385601, (2021)
2020
Preprints (*: corresponding author)
2025
arXiv: 2507.05143, submitted to SIAM/ASA Journal on Uncertainty Quantification, (2025)
Jiancheng Zhang, Xiangting Li, Xiaolu Guo, Zhaoyi You, Lucas Böttcher, Alex Mogilner, Alexander Hoffman, Tom Chou, Mingtao Xia* Reconstructing noisy gene regulation dynamics using neural stochastic differential equations
arXiv: 2503.09007, submitted to PLoS Computational Biology, (2025)
Mingtao Xia*, Qijing Shen, Philip Maini, Eamonn Gaffney, Alex Mogilner
arXiv: 2503.05068, submitted to Neural Networks, (2025)
2024
A local squared Wasserstein-2 method for efficient reconstruction of models with uncertainty
arXiv: 2406.06825, submitted to Journal of Machine Learning Research, (2024)
Squared Wasserstein-2 distance for efficient reconstruction of stochastic differential equations