Nuclear Medicine and Nanomaterials Laboratory
Principal Investigator: Ming-Hsien Chan, Ph.D.
Dr. Ming-Hsien Chan
Assistant Professor, Nuclear Medicine and Nanomaterials Laboratory
Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University
Address: Room 461, Biomedical Engineering Building, No. 155, Sec. 2, Linong Street, Taipei, 112 Taiwan
E-mail: mhchan@nycu.edu.tw
Office: +886-2-2826-7000 ext 67302
Biomedical Nanomaterials
Combining all evidence, NMN Lab developed a novel multifunctional nanocomposite as drug carrier can be applied for evaluating in vitro and in vivo treatment methods.
Nuclear Medicine Nanomaterials
NMN Lab has reported the preparation and physical characteristics of lanthanide-loaded upconversion nanoparticles
2008 Sep. – 2012 Jun.,
B.S., Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan
2012 Sep. – 2014 Jun.,
M.S., Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan
2014 Sep. – 2018 Jun.,
Ph.D., Department of Chemistry, National Taiwan University, Taipei, Taiwan
2018 Aug. – 2023 Jan.,
Postdoctoral Research Fellow, Genomics Research Center, Academia Sinica, Taipei, Taiwan
2018
Honorary Member of Physiologia/The Phi Tau Phi Scholastic Honor Society
2020
Outstanding Academia Sinica Post-Doctoral Fellowship/ Genomics Research Centers, Academia Sinica
Outstanding Paper Award/ Liver Disease Prevention & Treatment Research Foundation
2021
Outstanding R&D Substitute Serviceman/Research and Development Substitute Services
2023
Outstanding Young Scholar Award/Taiwan Nanomedicine Society
Selected Award/Young Investigators Awards for Pediatric Neuropsychiatric Science
Selected 1st and Corresponding Authored Publications
M. H. Chan and H. M. Lin*, “Preparation and Identification of Multifunctional Mesoporous Silica Nanoparticles for in vitro and in vivo Dual-Mode Imaging, Theranostics, and Targeted Tracking.” Biomaterials, 2015, 46, 149–158. DOI: 10.1016/j.biomaterials.2014.12.034
M. H. Chan, C. W. Chen, I. J. Lee, Y. C. Chan, D. Tu, M. Hsiao*, C. H. Chen, X. Chen, and R. S. Liu*, “Near-Infrared Light-Mediated Photodynamic Therapy Nanoplatform by the Electrostatic Assembly of Upconversion Nanoparticles with Graphitic Carbon Nitride Quantum Dots.” Inorg. Chem., 2016, 55, 10267–10277. DOI: 10.1021/acs.inorgchem.6b01522
M. H. Chan, Y. T. Pan, I. J. Lee, C. W. Chen, Y. C. Chan, M. Hsiao*, F. Wang, L. Sun, X. Chen, and R. S. Liu*, “Minimizing the Heat Effect of Photodynamic Therapy Based on Inorganic Nanocomposites Mediated by 808 nm Near-Infrared Light.” Small, 2017, 13, 1770038. DOI: 10.1002/smll.201700038
M. H. Chan and R. S. Liu*, “Advanced Sensing, Imaging, and Therapy Nanoplatforms Based on Nd3+-doped Nanoparticle Composites Exhibiting Upconversion Induced by 808 nm Near-Infrared Light.” Nanoscale, 2017, 9, 18153–18168. DOI: 10.1039/c7nr06693g
M. H. Chan, S. P. Chen, C. W. Chen, Y. C. Chan, R. J. Lin, D. P. Tsai, M. Hsiao*, R. J. Chung*, and R. S. Liu*, “Single 808 nm Laser Treatment Comprising Photothermal and Photodynamic Therapies by using Gold Nanorods Hybrid Upconversion Particles.” J. Phys. Chem. C, 2018, 122, 2402–2412. DOI: 10.1021/acs.jpcc.7b10976
M. H. Chan, Y. T. Pan, Y. C. Chan, M. Hsiao*, C. H. Chen, L. Sun, and R. S. Liu*, “Nanobubble-Embedded Inorganic Nanocomposites for Tumorous Multiple Imaging and Treatment.” Chem. Sci., 2018, 9, 3141–3151. DOI: 10.1039/c8sc00108a
L. E. Andrews#, M. H. Chan#, and R. S. Liu*, “Nano-lipospheres as Acoustically Active Ultrasound Contrast Agents: Evolving Tumor Imaging and Therapy Technique.” Nanotechnology, 2019, 30, 182001. DOI: 10.1088/1361-6528/aafeb9, #co-1st author
M. H. Chan, C. Y. Lai, Y. C. Chan, M. Hsiao*, R. J. Chung*, X. Chen, and R. S. Liu*, “Development of Upconversion Nanoparticle-Conjugated Indium Phosphide Quantum Dots for MMP2 Cancer Transformation Sensing.” Nanomedicine, 2019, 14, 1791–1804. DOI: 10.2217/nnm-2018-0524
M. H. Chan, R. S. Liu*, and M. Hsiao*, “Graphitic Carbon Nitride-Based Nanocomposites and Their Biological Applications: A Review.” Nanoscale, 2019, 11, 14993–15003. DOI: 10.1039/c9nr04568f
W. T. Huang#, M. H. Chan#, X. Chen, M. Hsiao*, and R. S. Liu*, “A Theranostic Nanobubble Encapsulating a Plasmonic-Enhanced Upconversion Hybrid Nanosystem for Targeted Cancer Therapy.” Theranostics, 2020, 10, 782–796. DOI: 10.7150/thno.38684, #co-1st author
M. H. Chan, M. R. Hsieh, R. S. Liu*, D. H. Wei*, and M. Hsiao*, “Magnetically Guided Theranostics: Optimizing Magnetic Resonance Imaging with Sandwich-Like Kaolinite-Based Iron/Platinum Nanoparticles for Magnetic Fluid Hyperthermia and Chemotherapy.” Chem. Mater., 2020, 32, 697–708. DOI: 10.1021/acs.chemmater.9b03552
M. H. Chan, W. T. Huang, J. Wang, R. S. Liu, and M. Hsiao*. “Next Generation Cancer-Specific Hybrid Theranostic Nanomaterials: MAGE-A3 NIR Persistent Luminescence Nanoparticles Conjugated to Afatinib for in-situ Suppression of Lung Adenocarcinoma Growth and Distal Metastasis.” Adv. Sci., 2020, 7, 1903741. DOI: 10.1002/advs.201903741
M. H. Chan, Y. C. Chan, R. S. Liu*, and M. Hsiao*, “A Selective Drug Delivery System Based on Phospholipid-Type Nanobubbles for Lung Cancer Therapy.” Nanomedicine, 2020, 15, 2689–2705. DOI: 10.2217/nnm-2020-0273
C. L. Cheng#, M. H. Chan#, S. J. Feng, M. Hsiao*, and R. S. Liu*, “Long-Term Near-Infrared Signal Tracking of the Therapeutic Changes of Glioblastoma Cells in Brain Tissue with Ultrasound-Guided Persistent Luminescent Nanocomposites.” ACS Appl. Mater. Interfaces, 2021, 13, 6099–6108. DOI: 10.1021/acsami.0c22489, #co-1st author
M. H. Chan#, W. Chen#, C. H. Li, C. Y. Fang, Y. C. Chang, D. H. Wei, R. S. Liu*, and M. Hsiao*, “An Advanced In Situ Magnetic Resonance Imaging and Ultrasonic Theranostics Nanocomposite Platform: Crossing the Blood−Brain Barrier and Improving the Suppression of Glioblastoma Using Iron-Platinum Nanoparticles in Nanobubbles.” ACS Appl. Mater. Interfaces, 2021, 13, 26759–26769. DOI: 10.1021/acsami.1c04990
Y. C. Chang#, M. H. Chan#, C. H. Li, C. Y. Fang, M. Hsiao*, and C. L. Chen, “Exosomal Components and Modulators in Colorectal Cancer: Novel Diagnosis and Prognosis Biomarkers.” Biomedicines, 2021, 9, 931. DOI: 10.3390/biomedicines9080931
M. H. Chan#, C. N. Lu#, Y. L. Chung, Y. C. Chang, C. H. Li, C. L. Chen*, D. H. Wei*, and M. Hsiao, “Magnetically guided theranostics: montmorillonite-based iron/platinum nanoparticles for enhancing in situ MRI contrast and hepatocellular carcinoma treatment.” J. Nanobiotechnology, 2021, 19, 308. DOI: 10.1186/s12951-021-01052-7
M. H. Chan#, B. G. Chen#, L. T. Ngo, W. T. Huang, C. H. Li, R. S. Liu*, and M. Hsiao*, “Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application.” Pharmaceutics, 2021, 13, 1874. DOI: 10.3390/pharmaceutics13111874 (JCR IF=6.321, 29/276; PHARMACOLOGY & PHARMACY)
Z. X. Chang, C. H. Li, Y. C. Chang, C. Y. F. Huang, M. H. Chan*, and M. Hsiao*, “Novel monodisperse FePt nanocomposites for T2-weighted magnetic resonance imaging: biomedical theranostics applications.” Nanoscale Adv., 2022, 4, 377–386. DOI: 10.1039/d1na00613d
M. H. Chan#, Z. X. Chang#, C. Y. F. Huang, L. James Lee, R. S. Liu*, and M. Hsiao*, “Integrated therapy platform of exosomal system: hybrid inorganic/organic nanoparticles with exosomes for cancer treatment.” Nanoscale Horiz., 2022, 7, 352–367. DOI: 10.1039/d1nh00637a
M. H. Chan, W. T. Huang, A. Satapathy, T. Y. Su, M. Hsiao*, and R. S. Liu*, “Progress and Viewpoints of Multifunctional Composite Nanomaterials for Glioblastoma Theranostics.” Pharmaceutics, 2021, 14, 456. DOI: 10.3390/pharmaceutics14020456
M. H. Chan, W. T. Huang, K. C. Chen, T. Y. Su, Y. C. Chan, R. S. Liu*, and M. Hsiao*, “The optical research progress of nanophosphors composed of transition elements in the fourth period of near-infrared windows I and II for deep-tissue theranostics.” Nanoscale, 2022, 14, 7123–7136. DOI: 10.1039/D2NR00343K
C. H. Li, Y. C. Chang, M. Hsiao*, and M. H. Chan*, “Ultrasound and Nanomedicine for Cancer-Targeted Drug Delivery: Screening, Cellular Mechanisms and Therapeutic Opportunities.” Pharmaceutics, 2022, 14, 1282. DOI: 10.3390/pharmaceutics14061282
M. H. Chan, B. G. Chen, W. T. Huang, T. Y. Su, M. Hsiao*, and R. S. Liu*, “Tunable single-atom nanozyme catalytic system for biological applications of therapy and diagnosis.” Mater. Today Adv., 2023, 17, 100342. DOI: 10.1016/j.mtadv.2023.100342
M. H. Chan, B. G. Chen, C. H. Li, W. T. Huang, T. Y. Su, L. Yin, M. Hsiao,* and R. S. Liu*, “Amplification of Oxidative Stress by Lipid Surface-Coated Single-Atom Au Nanozymes for Oral Cancer Photodynamic Therapy.” Nanoacale, 2023, 15, 15558–15572. DOI:10.1039/D3NR02088F
M. H. Chan* and Y. C. Chang*, “Recent Advances in Near-Infrared I/II Persistent Luminescent Nanoparticles for Biosensing and Bioimaging in Cancer Analysis.” Anal. Bioanal. Chem., 2024, 416, 3887–3905. DOI:10.1007/s00216-024-05267-z
M. H. Chan, C. Y. Lee, C. H. Li, Y. C. Chang, D. H. Wei,* and M. Hsiao*, “Magnetically Guided Theranostics: Novel Nanotubular Magnetic Resonance Imaging Contrast System Using Halloysite Nanotubes Embedded with Iron-Platinum Nanoparticles for Hepatocellular Carcinoma Treatment.” Small Struct., 2024, 5, 2300526. DOI:10.1002/sstr.202300526
M. H. Chan and R. S. Liu*, 2016, “Phosphors, Upconversion Nano Particles, Quantum Dots, and Their Applications, Volume 2, Chapter 38: Carbon Nitride Quantum Dots and Their Applications” Springer-Verlag Berlin Heidelberg. DOI: 10.1007/978-981-10-1590-8_17.
M. H. Chan, W. T. Huang, M. Hsiao, and R. S. Liu*, 2022, “Phosphor Handbook, Chapter 10: Design Growth of Nanophosphors and Their Applications” Taylor & Francis Group. DOI: 10.1201/9781003098669.
Department of Biomedical Imaging and Radiological Sciences
National Yang Ming Chiao Tung University
No.155, Sec.2, Linong Street, Taipei, 112 Taiwan
Office and laboratory: Room 461/462, Biomedical Engineering Building
E-mail : mhchan@nycu.edu.tw
Tel : +886-2-2826-7000 # 67302
Lab: +886-2-2826-7000 # 65968
Mobile phone: +886-934008716