Pharmaceutical Technology Research Unit

We aim to develop delivery systems that enhance drug bioavailbility and improve drug stability for pharmaceutics and cosmetics. The main research focuses on nano/microencapsulation employing lipid and polymer as a carriers, gastroretentive DDS, time-controlled pulsatile release DDS. Vaccine and tissue engineering are also our interests. Recently, the curcuminoids stability was improved by incorporation into solid lipid nanoparticles (SLN) using hot melt microemulsion technique. The clinical results also revealed that compared to the cream base, curcuminoids loaded SLNs cream significantly improve skin wrinkles, hydration, biological elasticity and viscoelasticity. The polymeric nanoparticle system based on chitosan and dextran sulfate has been successfully developed to incorporate amphotericin B, a model drug, to reduce nephotoxicity.

Examples of current research are as followed:

- Development of 3-dimension scaffold from silk fibroin for chondrocyte cultivation

- Development of cosmetic products based on Thai natural products such as pigment extract of silk cocoon, pomegranate peel extract and long pepper extract

- Development of delivery systems for lutein extract from silk cocoon

- Development of floating drug delivery system (pellets, tablets, capsules)

- Development of pulsatile release drug delivery systems.