Research

Our group's research focuses on advancing supramolecular chemistry by designing and investigating dynamic, complex molecular architectures. These molecular systems have the potential to transform fields such as materials science, molecular reactivity, and biological sensing. By exploring the intricate relationships between structure and function, we aim to develop innovative solutions to both fundamental and applied challenges.

Supramolecular Dynamic Architectures:
A significant part of our research is devoted to the development of complex molecular structures with unique and dynamic topologies. These supramolecular architectures are created through non-covalent interactions, allowing for the formation of highly adaptable and responsive molecular systems. We study how these structures assemble, how their topologies influence their chemical behavior, and how they can be manipulated under different environmental conditions. This work opens new doors for the creation of molecular machines, smart materials, and adaptive systems.

Reactivity in Confined Spaces:
Molecular reactivity can be dramatically altered when reactions occur in confined spaces, such as within supramolecular cages or capsules. We harness weak interactions such as hydrogen bonding, van der Waals forces, and metal coordination to control and modulate chemical reactions within these nanoscale environments. This control enables us to enhance reaction selectivity, accelerate reaction rates, and stabilize reactive intermediates that are difficult to study in bulk solution. By understanding how confinement affects reactivity, we contribute to the development of novel catalysts and reaction pathways that can be applied to synthetic chemistry and industrial processes.

Stimuli-Responsive Materials:
Our work on stimuli-responsive materials involves creating systems that change their properties in response to external factors like light, heat, pH, or chemical triggers. These materials have a wide range of potential applications, from smart coatings and drug delivery systems to molecular switches and sensors. By incorporating responsive elements into supramolecular architectures, we can design materials that adapt to their environment, offering precise control over their functionality and performance. This area of research is particularly relevant for developing advanced technologies in areas such as biomedical devices, environmental monitoring, and nanotechnology.

Out-of-Equilibrium Self-Assembly:
In nature, many biological systems operate far from equilibrium, constantly consuming energy to maintain order and function. Inspired by these natural processes, we are pioneering the design of self-assembling systems that operate out of equilibrium. These systems use external energy inputs, such as chemical fuels or light, to drive continuous assembly and disassembly cycles. By mimicking the dynamic behavior of biological systems, we aim to create materials that can adapt to changing environments, repair themselves, or perform complex tasks autonomously. This research has the potential to revolutionize the way we think about material design and functionality.

Sensors for Biological Applications:
Molecular sensing is a key focus of our research, particularly in the development of sensors for detecting biologically relevant molecules. We design supramolecular systems that can selectively bind to specific biomolecules, triggering a measurable response such as a change in fluorescence, color, or conductivity. These sensors have the potential to be used in medical diagnostics, environmental monitoring, and therapeutic applications. By tailoring the sensitivity and selectivity of these systems, we aim to create highly effective sensors for detecting diseases, monitoring drug levels, or identifying environmental contaminants.

Conclusion:
Our research pushes the boundaries of molecular chemistry by combining the principles of supramolecular chemistry, dynamic self-assembly, and material design. By focusing on the control of molecular behavior in confined spaces, the development of stimuli-responsive materials, and the creation of out-of-equilibrium systems, we are laying the foundation for new innovations in chemical reactivity, molecular sensing, and material science. Through these efforts, we aim to contribute to the advancement of science and the development of technologies that address real-world challenges in health, environment, and industry.