Publications

Systems pharmacology–based integration of human and mouse data for drug repurposing to treat thoracic aneurysms. Jens Hansen, Josephine Galatioto, Cristina I Caescu, Pauline Arnaud, Rhodora C Calizo, Bart Spronck, Sae-Il Murtada, Roshan Borkar, Alan Weinberg, Evren U Azeloglu, Maria Bintanel-Morcillo, James M Gallo, Jay D Humphrey, Guillaume Jondeau, Catherine Boileau, Francesco Ramirez, Ravi Iyengar, JCI insight, 4, 2019

Formulation and evaluation of cyclodextrin complexes for improved anticancer activity of repurposed drug: Niclosamide. A. Lodagekar, R. M Borkar, S. Thatikonda, R. B Chavan, VGM Naidu, N. R Shastri, R Srinivas, Naveen Chella. Carbohydrate polymers,212, 252-259

Isolation and structural characterization of degradation products of afatinib dimaleate by LC-Q-TOF/MS/MS and NMR: cytotoxicity evaluation of afatinib and isolated degradation products. B. B Chavan, V. Sawant, R. M Borkar, S. Ragampeta, MVN Kumar Talluri. Journal of pharmaceutical and biomedical analysis 166, 139-146

Identification and structural characterization of the stress degradation products of omeprazole using Q-TOF-LC-ESI-MS/MS and NMR experiments: evaluation of the toxicity of the degradation products. G Shankar, R. M Borkar, S. Udutha, M Kanakaraju, G Sai Charan, S Misra, R Srinivas. New Journal of Chemistry, 43, 19, 7294-7306

IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo. L. Guntuku, J. Kumar Gangasani, D. Thummuri, R. M.Borkar, B. Manavathi, S. Ragampeta, Jayathirtha Rao Vaidya, R. Sistla, Naidu G. M. Vegi. Oncogene. 2018, Nature Publishing Group. ( doi: 10.1038/s41388-018-0446-2)

Identification and structural characterization of in vivo metabolites of balofloxacin in rat plasma, urine and feces samples using Q-TOF/LC/ESI/MS/MS: In silico toxicity studies. G. Shankar, R M. Borkar, S.Udutha, S. Pal Anagoni, R. Srinivas. Journal of Pharmaceutical and Biomedical Analysis 159 (2018) 200–211.

Identification and Characterization of stress degradation products of sumatriptan succinate by using LC/Q‐TOF‐ESI‐MS/MS and NMR: Toxicity evaluation of degradation products. S. Udutha G. Shankar,R. M. Borkar, K. Kumar, G. Srinivasulu, Lalitha Guntuku, V.G.M. Naidu, R. Srinivas. Journal of Mass Spectrometry, (DOI:10.1002/jms.4266).

Avascular Necrosis of Femoral Head: A Metabolomic, Biophysical, Biochemical, Electron Microscopic and Histopathological Characterization. Aswath Narayanan, Prakash Khanchandani, R. M Borkar, C. R. Ambati, A. Roy, Xu Han, R. N Bhoskar, S. Ragampeta, F. Gannon, V. Mysorekar, B. Karanam, V. Sivaramakrishnan. Scientific reports, 7(1), 10721, Nature Publishing Group

Forced degradation studies of lansoprazole using LC‐ESI HRMS and 1H‐NMR experiments: in vitro toxicity evaluation of major degradation products. G Shankar, R. M Borkar, S. Udutha, L. Guntuku,VGM Naidu, N. Nagesh, R Srinivas. Journal of Mass Spectrometry, (DOI: 10.1002/jms.3949)

lower serum Vitamin D Metabolite levels in relation to circulating cytokines/chemokines and Metabolic hormones in Pregnant Women with hypertensive Disorders. R. Adela, R. M Borkar, N. Mishra, M. M.Bhandi, G. Vishwakarma, B Aparna Varma, S. Ragampeta, S. K Banerjee. Frontiers in Immunology, 8,2017(Equally Contributed)

Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion complex with HPβCD in polymeric nanoparticles. A. Kadari, S. Gudem, H. Kulhari, M. M. Bhandi, R. M Borkar,Venkata Ramana Murthy Kolapalli, R. Sistla. Drug delivery 24 (1), 224-232.

Novel sulfur metabolites of garlic attenuate cardiac hypertrophy and remodeling through induction of Na+/K+-ATPase expression. T. N Khatua, R. M Borkar, Soheb A Mohammed, Amit K Dinda, R Srinivas, Sanjay K Banerjee. Frontiers in pharmacology, 2017, 8.

Lower vitamin D metabolites levels were associated with increased coronary artery diseases in type 2 diabetes patients in India. R. Adela, R. M Borkar, M. M. Bhandi, G. Vishwakarma, P Naveen Chander Reddy, R Srinivas, S. K Banerjee. Scientific reports, 6, 37593, Nature Publishing Group.

In vivo metabolic investigation of silodosin using UHPLC–QTOF–MS/MS and in silico toxicological screening of its metabolites. C. Vishnuvardhan, S. Baikadi, R. M Borkar, R. Srinivas, N. Satheeshkumar.Journal of Mass Spectrometry, 51 (10), 677-692.

Study of Forced Degradation Behaviour of Brinzolamide Using LC–ESI–Q-TOF and In Silico Toxicity Prediction. C.Vishnuvardhan, D. Swain, R. Borkar, S Gananadhamu, R Srinivas, N Satheeshkumar. Chromatographia 79 (19-20), 1293-1308.

An Evaluation of the CYP2D6 and CYP3A4 inhibition potential of metoprolol metabolites and their contribution to drug-drug and drug-herb interaction by LC-ESI/MS/MS. R.M.Borkar, MM Bhandi, A.P. Dubey, V.G. Reddy, P.Komirishetty, P.P. Nandekar, A.T. Sangamwar, A. Kamal, S.K. Banerjee and R. Srinivas. Biomedical Chromatography, Wiley Publication. (DOI-10.1002/bmc.3721).

Identification of Leads for Antiproliferative Activity on MDA-MB-435 Human Breast Cancer Cells through Pharmacophore and CYP1A1-mediated Metabolism. P. P Nandekar, K.Khomane, V Chaudhary, V.P. Rathod, R.M Borkar, MM Bhandi, R Srinivas, AT Sangamwar, S.K.Guchhait and A.K.Bansal. European Journal of Medicinal Chemistry, DOI-10.1016/j.ejmech.2016.02.061.

Identification and characterization of stressed degradation products of rabeprazole using LC-ESI/MS/MS d 1H-NMR experiments: in vitro toxicity evaluation of major degradation products. MM Bhandi, R.M Borkar, G Shankar, S Raut, N Nagesh, R Srinivas. RSC Advances 6 (13), 10719-10735.

Baicalein alleviates doxorubicin-induced cardiotoxicity via suppression of myocardial oxidative stress and apoptosis in mice. BD Sahu, JM Kumar, M Kuncha, R.M Borkar, R Srinivas, R Sistla. Life sciences, 2016, 144, 8-18.

Evaluation of Garlic Organosulfur Volatiles, Diallyl Disulphide and Diallyl Sulphide as a New Anti-Glycating Compound by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry- An Insulin Based Glycation Assay. R.M Borkar, M.M Bhandi, M. Ajitha, S.K Banerjee, R. Srinivas. International Journal of Advanced Technology in Enginerring and Science, 2015, 3(1), 257-264.

Characterization of degradation products of Ivabradine by LC‐HR‐MS/MS: a typical case of exhibition of different degradation behaviour in HCl and H2SO4 acid hydrolysis. P.Patel, R.M Borkar, PD Kalariya, RP Gangwal, AT Sangamwar, S Gananadhamu, R Srinivas. Journal of Mass Spectrometry, 2015, 50 (2), 344-353.

Plasma protein binding, pharmacokinetic, tissue distribution and CYP450 biotransformation studies of fidarestat by ultra high performance liquid chromatography- high resolution mass spectrometry R.M Borkar, M.M Bhandi, A.P Dubey, P.P Nandekar, A.T Sangamwar, SK. Banerjee and R. Srinivas. Journal of Pharmaceutical and Biomedical Analysis, 2015, 102, 386-399.

Liquid chromatography electrospray ionization tandem mass spectrometry study of nilutamide and its stress degradation products: in silico toxicity prediction of degradation products. A Ramesh Babu, R.M.Borkar, G Raju, B Raju, R Srinivas. Biomedical Chromatography, 2014, 28 (6), 788.

Naringin ameliorates gentamicin-induced nephrotoxicity and associated mitochondrial dysfunction, apoptosis and inflammation in rats: Possible mechanism of nephroprotection. BD Sahu, S Tatireddy, M Koneru, R.M Borkar, J.M Kumar, M Kuncha, R Sistla. Toxicology and applied pharmacology, 2014, 277 (1), 8-20.

Garlic Attenuates Cardiac Oxidative Stress via Activation of PI3K/AKT/Nrf2-Keap1 Pathway in Fructose-Fed Diabetic Rat. R Padiya, D Chowdhury, R.M Borkar, R Srinivas, MP Bhadra, SK Banerjee. PloS one, 2014, 9 (5), e94228.

Characterization of forced degradation products of ketorolac tromethamine using LC/ESI/Q/TOF/MS/MS and in silico toxicity prediction. P.D Kalariya, B Raju, R.M Borkar, D Namdev, S Gananadhamu, R Srinivas. Journal of Mass Spectrometry, 2014, 49 (5), 380-391.

Identification of forced degradation products of tamsulosin using liquid chromatography/electrospray ionization tandem mass spectrometry. D Namdev, R.M Borkar, B Raju, PD Kalariya, VT Rahangdale, S Gananadhamu, R Srinivas. Journal of pharmaceutical and biomedical analysis, 2014, 88, 245-255.

Liquid chromatography/electrospray ionization tandem mass spectrometric study of milnacipran and its stressed degradation products. R.M Borkar, B Raju, PS Devrukhakar, N Tondepu, ABN Rao, R Srinivas. Rapid Communications in Mass Spectrometry, 2013, 27 (2), 369-374.

A Validated Stability-Indicating RP-HPLC Method for the Simultaneous Determination of Tenofovir, Emtricitabine, and a Efavirenz and Statistical Approach to Determine the Effect of Variables PS Devrukhakar, R.M Borkar, N Shastri, KV Surendranath, ISRN Chromatography 2013.

Development and validation of liquid chromatography–mass spectrometric method for simultaneous determination of moxifloxacin and ketorolac in rat plasma: application to pharmacokinetic study. B Raju, M Ramesh, R.M Borkar, R Padiya, SK Banerjee, R Srinivas. Biomedical Chromatography, 2012, 26 (11), 1341-1347.

In vivo metabolic investigation of moxifloxacin using liquid chromatography/electrospray ionization tandem mass spectrometry in combination with online hydrogen/deuterium exchange experiments. B Raju, M Ramesh, R.M Borkar, R Srinivas, R Padiya, SK Banerjee. Rapid Communications in Mass Spectrometry, 2012, 26 (16), 1817-1831.

Identification and structural characterization of in vivo metabolites of ketorolac using liquid chromatography electrospray ionization tandem mass spectrometry (LC/ESI‐MS/MS). B Raju, M Ramesh, R.M Borkar, R Padiya, SK Banerjee, R Srinivas Journal of mass spectrometry, 2012, 47 (7), 919-931.

Identification and characterization of stressed degradation products of metoprolol using LC/Q‐TOF‐ESI‐MS/MS and MSn experiments. R.M Borkar, B Raju, R Srinivas, P Patel, SK Shetty. Biomedical Chromatography, 2012, 26 (6), 720-736.

34. RP-HPLC separation method for individual components of polycap in presence of their degradation/interaction products. SK Shetty, R.M Borkar, PS Devrukhakar, KV Surendranath, P Radhakrishnanand, J Satish, N Shastri, J Jogul, U M Tripathi. Journal of Liquid Chromatography & Related Technologies, 2012, 35 (5), 662-676.

Stress Degradation Behavior of a Polypill and Development of Stability Indicating UHPLC Method for the Simultaneous Estimation of Aspirin, Atorvastatin, Ramipril and Metoprolol Succinate. SK Shetty, KV Surendranath, P Radhakrishnanand, R.M Borkar. P S Devrukhakar, J Jogul, U M Tripathi. American Journal of Analytical Chemistry,2011, 2 (04), 401.

Quantitative application to a polypill by the development of stability indicating LC method for the simultaneous estimation of aspirin, atorvastatin, atenolol and losartan potassium. SK Shetty, KV Surendranath, P Radhakrishnanand, R.M Borkar. P S Devrukhakar, J Jogul, U M Tripathi. American Journal of Analytical Chemistry, 2010, 1 (02), 59.