Welcome to the "Tumor Evolution and Molecular Therapeutics (TEMT)" Lab

The major research interests of our lab revolve around understanding the complex processes and signalling associated with therapy-induced clonal evolution in cancers. Our research is focused on establishing several novel in vitro cancer cell models to address the fundamental questions behind the phenotypic and genotypic attributes in cancer clones that drive the critical metastasis events during the evolution of drug-resistant cancer. We are also interested in understanding the molecular mechanisms involved with cancer cell metastasis, for instance, the molecular mechanism behind individual and collective cell migrations of cancer cells. Recently, our team has identified a couple of key molecular regulators of ovarian and breast cancer cell adhesion and invasion. Now, we are working towards developing novel peptides and combination therapies to obstruct the metastasis in these cancer models. Our studies employ various normal and cancer cell lines, patient-derived cancer tissue, and in vivo small rodent models. Recently, we have developed an interest in biomaterial research that could be used in in vitro or in vivo cancer studies. Our research is supported by two large grants from DBT and SERB-CRG, as well as grants from DoP, Govt. of India. We are thankful to our national and international collaborators for their valuable support.