Research Area

1. Enantioselective Pharmacokinetic and Pharmacodynamic Studies

The group focuses on the enantioselectivity present in drug-protein interactions that can inhibit the pharmacokinetics of the enantiomers, which may effects the therapeutic properties and toxicity levels. Enantiomers can be metabolized by different enzyme systems, resulting in variations in the rate of metabolic clearance. In addition, factors such as age and sex can also influence the enzyme metabolism of enantiomers. Currently our research area focuses on establishing the pharmacokinetics, toxicokinetic, metabolite profiling, drug-drug and gender relation variations of the racemic drugs.

2. Phyto-metabolomic study of the plants from North-East region of India

 The main purpose of phyto-metabolomics is to study different complex plant extracts for metabolite exploration and the discovery of phyto constituents responsible for medicinal value. Plant metabolomics is collection of accurate and selective chemical information where the maximum number of detected metabolites and their molecular assignment are included. Metabolomics provide information and better understanding of the complexity of the plant metabolic composition, metabolism, and their therapeutic activity to the plant biology researchers. The workflow mainly involves extraction of the plant material followed by the identification of all possible metabolites by using GC-MS, LC-MS/MS and LC-QTOF. Then the plant extracts will be checked for the activity in both in-vitro cell lines and in in-vivo disease models. Based on the result, further bioactivity guided fractionation, isolation, and characterization of standardized extracts will be carried out by using Flash chromatography, preparative HPLC and further characterization by UV, FT-IR, NMR and Mass spectrometry techniques.