PUBLICATIONS

2025

Nai-Shu Hsu, Cong Tang, Raquel V Mendes, Carlos Labão-Almeida, ... Rita Fior, Gonçalo JL Bernardes. Tumour-specific STING agonist synthesis via a two-component prodrug system. Nature Chemistry, 1-11

Mendes, R.V., Ribeiro, J.M., Gouveia, H. et al. Fior, R. Zebrafish Avatar testing preclinical study predicts chemotherapy response in breast cancer. Nature Precision Oncology. 9, 94 (2025).

Rute Salvador, Bruna Filipa Correia, Daniela Grosa, Telma Martins, ...Cátia Rebelo de Almeida, Rita Fior, Antonio Jacinto, Carolina Mathias, Sofia Braga, M Guadalupe Cabral. HLA-DR expression in cytotoxic T lymphocytes: a key to boost the therapeutic potential of T cell-based strategies for breast cancer. Frontiers in Immunology 16, 1653970.

M Mohiuddin, V Póvoa, R Fior, FA Sinicrope. Novel CDK2/CDK9 inhibitor fadraciclib targets cell survival and DNA damage pathways and synergizes with encorafenib in human colorectal cancer cells with BRAF (V600E). Oncogenesis 14 (1), 27.

2024

VB Unnikrishnan, Valerio Sabatino, Filipa Amorim, Marta F Estrada, Claudio D Navo, Gonzalo Jimenez-Oses, Rita Fior, Gonçalo JL Bernardes. Gold (III)-Induced Amide Bond Cleavage In Vivo: A Dual Release Strategy via π-Acid Mediated Allyl Substitution. Journal of the American Chemical Society 146 (33), 23240-23251

MF Martínez-López, CR de Almeida, M Fontes, RV Mendes, Stefan HE Kaufmann, Rita Fior. Macrophages directly kill bladder cancer cells through TNF signaling as an early response to BCG therapy. Disease Models & Mechanisms 17 (8), dmm050693

Costa, B., Estrada, M.F., Gomes, A. et al. Fior, R. Zebrafish Avatar-test forecasts clinical response to chemotherapy in patients with colorectal cancer. Nat Commun 15, 4771 (2024). 

2023 

Mariana Rebordão-Pires, Marta F Estrada, António Gomes, Filipa Silva, Carlota Baptista, Maria João Ramos, Ana Fortuna, Pedro Simões, Gabriela Sousa, Ana Marreiros, Rita Fior. Relapsed Ovarian Cancer Patients with Ascites and/or Pleural Effusion Still Benefit from Treatment: A Real-Life Study. Cancers 2024, 16(1), 162; https://doi.org/10.3390/cancers16010162

Gean M. Dal Forno, Eloah Latocheski, Ana Beatriz Machado, J...., Rita Fior, Josiel B. Domingos, and Gonçalo J. L. Bernardes. Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C–C Bond Cleavage Reactions. JACS Journal of the American Chemical Society 2023 145 (19), 10790-10799.

2022

Sousa, B, Rebelo de Almeida, C... Seixas, JD, Fior, R and Gonçalo J. L. Bernardes. Selective Inhibition of Bruton’s Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors. ACS Pharmacol. Transl. Sci. 2022, 5, 11, 1156–1168

Costa B*., Fernandez L. M*., Parés O., Rio-Tinto R., Santiago I., Castillo-Martin M., Parvaiz A., Fior R*. Zebrafish Avatars of rectal cancer patients validate the radiosensitive effect of metformin. Frontiers in Oncology 2022 12.

Costa, B., Estrada, M. F., Barroso, M. T., & Fior, R*. Zebrafish patient-derived avatars from digestive cancers for anti-cancer therapy screening. Current Protocols, 2022 2, e415

2021

R Cruz-Duarte, C Rebelo de Almeida, M Negrão, .. R Fior, L Costa, M Martins*. Predictive value of a novel PLCγ1-dependent mechanism of cetuximab resistance in RAS WT metastatic colorectal cancer. Clin Cancer Res (2022) 28 (6): 1203–1216.

Tavares Barroso, M.; Costa, B.; Rebelo de Almeida, C.; Castillo Martin, M.; Couto, N.; Carvalho, T.; Fior, R*. Establishment of Pancreatobiliary Cancer Zebrafish Avatars for Chemotherapy Screening. Cells, 10, 2077.

Albuquerque C, Vanneschi L, Henriques R, Castelli M, Póvoa V, Fior R, et al. (2021) Object detection for automatic cancer cell counting in zebrafish xenografts. PLoS ONE (2021) 16(11): e0260609.

Martinez-Lopez, M, Póvoa, V and Fior, R*. Generation of Zebrafish Larval Xenografts and Tumor Behavior Analysis. Journal of Visualized Experiments (JoVE).(2021) (172), e62373

Póvoa, V, Rebelo de Almeida, C, Maia-Gil, M, Domingues, M, Martinez-Lopez, M, Almeida Fuzeta, M, Silva, C, and Fior, R*. Innate immune evasion revealed in a colorectal zebrafish xenograft model. Nature Communications (2021)12, 1156

2020

Varanda, A.B.; Martins-Logrado, A.; Ferreira, M.; Fior, R*. Zebrafish Xenografts Unveil Sensitivity to Olaparib beyond BRCA Status. Cancers, 12, 1769;

Rebelo de Almeida; C, Mendes,R;....and Fior, R*. Zebrafish xenografts as a fast screening platform for bevacizumab cancer therapy. Communications Biology (NPG) 3, 299;

Oliveira, BL*; Stenton, BJ; Unnikrishnan, V. B.; Rebelo de Almeida, C; Conde,J; Negrão, M; .... Fior*,R; and Bernardes,GJL*. Platinum-Triggered Bond-Cleavage of Pentynoyl Amide and N-Propargyl Handles for Drug-Activation. Journal of the American Chemical Society 142 (24),10869-10880.

Costa B, Estrada, M, Mendes RV and Fior R*. Zebrafish Avatars towards personalized medicine-a comparative review between Avatar models. Cells 9(2), 293;

Basti, A.; Fior, R.; Yalҫin, M.; Póvoa, V.; Astaburuaga, R.; Li, Y.; Naderi, J.; Godinho Ferreira, M.; Relógio, A. The Core-Clock Gene NR1D1 Impacts Cell Motility In Vitro and Invasiveness in a Zebrafish Xenograft Colon Cancer Model. Cancers, 12, 853. 

Poté N., Cros J., Laouirem S., Raffenne J., Negrao M., Albuquerque M., Bedossa P., Godinho Ferreira M., AIT-SI-ALI S., Fior R., and Paradis, V. The histone acetyltransferase hMOF promotes vascular invasion in hepatocellular carcinoma. Liver International; 40: 956– 967.

Costa,B; Ferreira,S; Póvoa,V; Parés, O; Cardoso, MJ; Vieira, Stroom, SJ; Fidalgo, P; Rio-Tinto, R; Figueiredo, N; Greco, C; Ferreira, MG* and Fior, R*. Developments in Zebrafish Avatars as Radiotherapy Sensors-Towards Personalized Medicine. EBiomedicine. 51, 102578

2018

Fior R* and Ferreira MG*. Reply to Katsu and Baker: Using zebrafish PDX to screen drug sensitivity of endocrine-dependent cancers. Proc Natl Acad Sci U S A.

Fernandes, SF; Fior, R; Pinto, F; Gama-Carvalho, M and Saúde, L. Fine-tuning of fgf8a expression through alternative polyadenylation has a selective impact on Fgf-associated developmental processes. Biochimica et Biophysica Acta (BBA) 1861 (9), 783-793.

2017

Fior R*, Póvoa V, Mendes RV, Carvalho T, Gomes A, Figueiredo N, Ferreira MG*. Single cell functional and chemosensitive profiling of combinatorial colorectal. Proc Natl Acad Sci USA. Aug 23.

2012

Fior, R*; Maxwell, AA; Ma, TA; Vezzaro, A;  Moens, CB; Amacher,SL; Lewis, J; Saúde L*.Differentiation and movement of presomitic mesoderm progenitor cells are coupled by Mesogenin1. Development 139: 4656-4665;

Cutty, S J, Fior, R, Henriques, P, Saúde, L and Wardle, FC. Identification and expression of zebrafish mesp-ab and mesp-bb genes. Int J. Dev Biol 113447sc;

2011

Fior, R#, Vilas-Boas,F#, Swedlow,J, Storey, KG and Henrique, D. A novel Reporter of Notch Signalling indicates regulated and random Notch Activation during Vertebrate Neurogenesis. BMC Biology. Aug 31;9:58. #1st co-authorship;

2009

Fior, R and Henrique, D. Notch-Off: A perspective on the termination of Notch signalling. Review. Int J Dev Biology.;53(8-10):1379-84;

2005

Fior, R and Henrique, D. A novel hes5/hes6 circuitry of negative regulation controls Notch activity during neurogenesis. Dev Biol. 2005 May 15;281(2):318-33;