Past Internships and Projects

Process Development and Technology Operations Intern, Immunovant, Roivant Sciences                                                 May 2019-December 2019

Durham, NC, USA

Immunovant is a clinical-stage biopharmaceutical company focused on enabling normal lives for patients with autoimmune diseases. Their  investigational product candidate, IMVT-1401 (formerly known as RVT-1401), is a novel, fully human monoclonal antibody targeting the neonatal Fc receptor (FcRn).

My tasks included:

• Created master datafiles and process description of upstream, downstream, analytical assays and release/stability characterization of drug substance/drug product data of an Anti-FcRn monoclonal antibody, visualized process variability by graphing control charts and calculated process performance. 

•  Performed statistical analysis of tech transfer runs between different CMOs and Design of Experiment runs to optimize process parameters for cGMP manufacturing of drug substance. 

• Tracked and organized CMC purchase orders, budget allocations, generated timelines and Gantt Charts for CMC activities, and maintained records of shipment and storage of drug substance and product. 

• Performed multivariate data analysis and statistical tests on analytical assays and upstream manufacturing data. 

• Assisted in writing of CMC section for IND/IMPD submission and authored Change Control Documents for tech transfer. 

Summer Research Assistant, Department of Mathematics and Statistics, University of Saskatchewan, Canada June 2017-July 2017

Prof. Chris Soteros Lab

Project title: Probability of DNA knotting 

It was an integrative research project which inculcates researchers from various backgrounds like engineering, mathematics and statistics, molecular biology and chemistry. I performed simulations using Monte Carlo Markov Chain algorithm known as Pivot Algorithm to obtain Knot Probabilities of DNA using an Energy Parameter model. Simulation results were compared with experimental data of Shaw and Wang for Knotting Probabilities of DNA. I went ahead to optimize the parameters of the model, A (related to charge density) and v (short range attractive force between monomers) by using an adaptive Robbins Monro Algorithm.

The work gained recognition at the International Conference on "Knots and Polymers: Aspects of topological entanglement in DNA, proteins and graph- shaped polymers", in Tokyo Japan. 

Summer Research Intern, Department of Chemical Engineering, Indian Institute of Technology-Guwahati, India May 2016-July 2016

Prof. V.V Goud Lab

Project title: Reactive extraction of Nahar Oil Seeds

I had worked on the process of reactive extraction of Nahar ( mesua ferrea) seeds for the production of biodiesel. The main objective of my project was to optimize the parameters for reactive extraction of nahar oil seeds, which included catalyst loading, methanol to seed ratio, reaction temperature and reaction time. The acid value of the biodiesel produced was evaluated for the reaction matrix. NMR, FTIR analysis was performed for the various biodiesel samples produced. During my entire tenure as an intern I gained sufficient knowledge in the field of biodiesel production both in the laboratory scale as well as the pilot scale.