General Repurposing References

Rapid repurposing of drugs for COVID-19

Guy, R.K., Dipaola, R.S., Romanelli, F., and Dutch, R.E. (2020) Science

Machine learning identifies candidates for drug repurposing in Alzheimer’s disease

Rodriguez, S., Hug, C., Todorov, P., Moret, N., Boswell, S.A., Evans, K., Zhou, G., Johnson, N.T., Hyman, B.T., Sorger, P.K., Albers, M.W., and Sokolov, A. (2021) Nature Communications

Off-Patent Drug Repositioning

Avram, S., Curpan, R., Halip, L., Bora, A., and Oprea, T. (2020) Journal of Chemical Information and Modeling

Generic Drug Repurposing For Public Health And National Security: COVID-19 And Beyond

Conti, R.M., Athey, S., Frank, R.G., and Gruber, J. (2020) Health Affairs

Generics 2030: Where Are We Heading in 2030 for Generic Drug Science, Research, and Regulation?

Zhang, L., Lionberger, R.A. (2020) Clinical Pharmacology & Therapeutics

Incorporating Real-World Evidence Within The Label Of An FDA-Approved Drug: Perspectives From BIO Membership

BIO - Biotechnology Innovation Organization (2019)

Drug repurposing: progress, challenges and recommendations

Pushpakom, S., Iorio, F., Eyers, P. et al. (2019) Nature Reviews Drug Discovery

Challenges and Benefits of Repurposing Products for Use during a Radiation Public Health Emergency: Lessons Learned from Biological Threats and other Disease Treatments

DiCarlo, A.L., Cassatt, D.R., Dowling, W.E., Esker, J.L., Hewitt, J.A., Selivanova, O., Williams, M.S., Price, P.W. (2018) BioOne COMPLETE

Outdated Prescription Drug Labeling: How FDA-Approved Prescribing Information Lags Behind Real-World Clinical Practice

Shea, M.B., Stewart, M. , Van Dyke, H. , Ostermann, L. , Allen, J. , and Sigal, E. (2018) Therapeutic Innovation & Regulatory Science

Giving Drugs a Second Chance: Overcoming Regulatory and Financial Hurdles in Repurposing Approved Drugs As Cancer Therapeutics

Hernandez, J.J., Pryszlak, M., Smith, L., Yanchus, C., Kurji, N., Shahani, V.M., and Molinski, S.V. (2017) Frontiers in Oncology

Towards a hit for every target

Rees, S., Gribbon, P., Birmingham, K., Janzen, W.P., and Pairaudeau, G. (2016) Nature Reviews Drug Discovery

Pioneering government-sponsored drug repositioning collaborations: progress and learning

Frail, D.E., Brady, M., Escott, K.J., Holt, A., Sanganee, H.J., Pangalos, M.N., Watkins, C., and Wegner, C.D. (2015) Nature Reviews Drug Discovery

Bring out your dead

Editorial (2015) Nature Biotechnology

The Benefits Of Drug Repositioning

Persidis, A. (2011) Drug Discovery World

COVID-19 in ASCPT

About: ASCPT and the disciplines of clinical pharmacology and translational science are poised to play a role in fighting the COVID-19 pandemic through the rigorous research of our members and committing to publishing top-notch research from all over the world. COVID-19 therapies will be, broadly speaking, repurposing of existing (approved) drugs in the short term, development of vaccines in the mid term, and discovery of new mechanisms of action and development of novel drugs in the long term. The research being published in the three journals of the ASCPT Journal Family reflects these varying horizons. We will be adding to this collection as more data become available, and as more treatments are considered.