Topic-focused Workshops
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In silico Drug Discovery Workshop
Oct. 23-24, 2024
The National Center for Advancing Translational Sciences (NCATS) Assay Guidance Manual (AGM) program hosted a two-day workshop that covered a broad range of critical concepts, including practical approaches and best practices, to successfully develop and integrate accurate, robust, and rigorous AI/ML methods/models into drug discovery pipelines and to facilitate discussions around utilization of such methodologies. Many of the speakers are pioneers of covered scientific topics and the listed workshop sessions aim to share the fundamentals and modern knowledge to facilitate learning for both novice and established practitioners. This workshop was jointly organized by NCATS, Biomedical Advanced Research and Development Authority (BARDA), University of California San Diego (UCSD), and The University of North Carolina at Chapel Hill (UNC).
Assay Guidance Workshop on Sample Management
Oct. 26, 2023
The National Center for Advancing Translational Sciences (NCATS) Assay Guidance Manual (AGM) program hosted a half-day workshop that covered a broad range of critical concepts, including practical approaches to, and best practices in, sample management. This workshop also covered emerging technologies and trends in sample management, including novel platforms, and management of biologics, antisense oligonucleotides, natural products, and others. This workshop was organized in memory of our colleague, Paul Shinn, who passed away last fall. Paul was a foundational member of NCATS and its Division of Preclinical Innovation (DPI)’s compound management group leader.
Assay Guidance Workshop on 3D Tissue Models for Antiviral Drug Development
June 7-8, 2022
The National Center for Advancing Translational Sciences (NCATS) Assay Guidance Manual (AGM) program hosted a two-day workshop that covered a broad range of critical concepts, including practical approaches and best practices, for developing standardized 3D cellular assays with the hope of helping the community to successfully develop therapeutics for future pandemic threats. This workshop was jointly organized by NCATS, the National Institute of Allergy and Infectious Diseases (NIAID) and the Bill & Melinda Gates Foundation. The overall goal of this workshop was to help scientists establish robust, reproducible, scalable, consistent, advanced 3D tissue models to study pandemic threat viruses.
Assay Guidance Workshop for Cell-Based Assays and Lead Discovery
Nov. 16-17, 2021
The NCATS Assay Guidance Manual (AGM) program hosted a two-day workshop that covered a broad range of critical concepts underlying high-content screening and analysis (Day 1) and complex in vitro models (CIVMs) in drug discovery (Day 2). This workshop was designed to disseminate critical information about the implementation of robust cellular assay methods and is particularly relevant for researchers developing molecular probes or clinical candidates. Many of the workshop instructors have 20 to 30 years of experience in the field of drug discovery and shared information not readily found in a classroom or published material outside of the AGM.
The goal of this workshop was to train scientists on the fundamentals and applications of image-based and 3D cellular assay technologies and engage in a dialogue with those curious to understand it on a deeper level. This workshop also discussed challenges and standards for rigor to enable reproducible results, and provided a future perspective on the utility of complex cellular models in drug discovery.
AGM Workshop on DNA-Encoded Libraries for Lead Discovery
Sept. 1-2, 2021
While attention around the use of DNA-Encoded Libraries (DEL) has rapidly grown over the past decade key aspects of DEL design and production, as well as their use for lead discovery, are scarcely detailed in the literature.
NCATS Assay Guidance Manual (AGM) program has taken keen notice of this emerging technology and hosted a two-day virtual workshop to seed discussion of best practices for using DELs. Many of the instructors are pioneers and experienced developers of the technology, and sessions were aimed at sharing DEL fundamentals to facilitate uptake and learning for both novice and established users. The workshop included four sessions and featured seminars that highlighted critical concepts about the technology including DEL library design & production, affinity selection strategy and execution, sequencing and data analysis; and closed with a panel discussion about emerging trends and technological advances in the DEL field.
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