Publications
2023
Záhonová K, Füssy Z, Stairs CW, Leger MM, Tachezy J, Čepička I, Roger AJ, Hampl V. 2023. Comparative analysis of mitochondrion-related organelles in anaerobic amoebozoans. Microbial Genomics, 9 (11). https://doi.org/10.1099/mgen.0.001143
Kučerová J., Zdrha A., Shinde A., Harant K., Hrdý I., Tachezy J. 2023. The divergent ER-mitochondria encounter structures (ERMES) are conserved in parabasalids but lost in several anaerobic lineages with hydrogenosomes. BMC Biology, 21, 259. DOI 10.1186/s12915-023-01765-1
Javier del Campo, Maria Carlos-Oliveira, Ivan Čepička, Elisabeth Hehenberger, Aleš Horák, Anna Karnkowska, Martin Kolisko, Enrique Lara, Julius Lukeš, Tomáš Pánek, Kasia Piwosz, Daniel J. Richter, Pavel Škaloud, Robert Sutak, Jan Tachezy, Vladimír Hampl. 2023. The protist cultural renaissance. Trends in Microbiology, 14:S0966-842X(23)00328-1. doi: 10.1016/j.tim.2023.11.010.
Záhonová, Low R.S., Warren C.J., Cantoni D., Herman E. K., Yiangou L., Ribeiro C.A., Phanprasert Y., Brown I.R., Rueckert S., Baker N.L., Tachezy J., Betts E.L., Gentekaki E., van der Giezen M., Clark C.G., Jackson A.J., Dacks J.B. Tsaousis A.D.. 2023. Evolutionary cell biological analysis of Proteromonas reveals the path to cellular reduction and anaerobicity in the hyper-prevalent gut microbe Blastocystis. Current Biology, 33:1-16 https://doi.org/10.1016/j.cub.2023.05.025
2022
Tachezy J., Makki R., Hrdý I. 2022. The hydrogenosomes of Trichomonas vaginalis. Journal of Eukaryotic Microbiology. e12922. doi: 10.1111/jeu.12922.
Rada P, Hrdý I, Zdrha A, Narayanasamy R.K., Smutná T., Beneš V, Tang P, and Tachezy J. Double stranded RNA viruses are released from Trichomonas vaginalis inside exosomes and modulate the exosomal cargo. Frontiers in Microbiology, https://doi.org/10.3389/fmicb.2022.893692.
Ong S.C., Cheng W.-H., Ku F.-M., Tsai C.-Y., Huang P.-J, Lee C.-C., Yeh Y.-M. Lin R., Luo H.-W., Chiu C.-H., Tachezy J., and Tang P. 2022. Identification of endosymbiotic virus in small extracellular vesicles derived from Trichomonas vaginalis. Genes, 13(3):531. doi: 10.3390/genes13030531.
Záhonová K., Treitli S.C., Le T., Škodová-Sveráková I., Čepička I., Tachezy J., Hampl V. 2022. Anaerobic derivates of mitochondria and peroxisomes in the free-living amoeba Pelomyxa schiedti revealed by single-cell genomics. bioRxiv preprint doi: https://doi.org/10.1101/2021.05.20.444135, BMC Biology, 20(1):56. doi: 10.1186/s12915-022-01247-w.
Zimmann N., Rada P., Žárský V., Smutná T., Záhonová K., Dacks J., Harant K., Hrdý I., Tachezy J. 2022. Proteomic analysis of Trichomonas vaginalis phagolysosome, lysosomal targeting, and unconventional secretion of cysteine peptidases. Mol Cell Proteomics 21(1):100174. DOI:https://doi.org/10.1016/j.mcpro.2021.100174
Smutná T., Dohnálková A., Sutak R., Narayanasamy R.K., Tachezy J, Hrdý I. 2022. A cytosolic ferredoxin-independent hydrogenase possibly mediates hydrogen uptake in Trichomonas vaginalis. Current Biology, First published: November 10, 2021, S0960-9822(21)01494-9. doi: 10.1016/j.cub.2021.10.050.
Narayanasamy R. K., Rada P., Zdrha A., van Ranst M, Neyts J., Tachezy J. 2022. Cytidine nucleoside analog is an effective antiviral drug against Trichomonasvirus. Journal of Microbiology, Immunology and Infection, 55(2):191-198. doi: 10.1016/j.jmii.2021.08.008.
2021
Verner Z, Žárský V, Le T, Narayanasamy R, Rada P., Rozbeský D., Makki A., Belišová D., Hrdý I, Vancová M., Lender C., König C., Bruchhaus I, Tachezy J. 2021. Anaerobic peroxisomes in Entamoeba histolytica metabolize myo-inositol. PLoS Pathogens, 17(11):e1010041.
Pyrih J., Žárský V., Fellows D.J., Grosche C., Wloga D., Striepen B, Maier G.U., Tachezy J. The iron-sulfur scaffold protein HCF101 unveils the complexity of organellar evolution in SAR, Haptista and Cryptista. BMC Ecology and Evolution 21(1):46. doi: 10.1186/s12862-021-01777-x.
Žárský V., Klimeš V., Pačes J., Vlček Č, Hradilová M., Beneš V., Nývltová E., Hrdý I., Pyrih J, Mach J., Barlow L., Stairs C.W., Eme L., Hall N., Eliáš M., Dacks BJ, Roger A., Tachezy J. 2021. The Mastigamoeba balamuthi genome and the nature of the free-living ancestor of Entamoeba. Mol. Biol. Evol. doi: 10.1093/molbev/msab020. Online ahead of print. PMID: 33528570
Rout S., Oeljeklaus S., Makki A., Tachezy J., Warscheid B. and Schneider A. 2021. Determinism and contingencies shaped the evolution of mitochondrial protein import receptors. Proc Natl Acad Sci U S A. Feb 9;118(6):e2017774118. doi: 10.1073/pnas.2017774118. PMID: 33526678.
2020
Le T., Žárský V., Nývltová E., Rada P., Harant K., Vancova M.,Verner Z., Hrdý I., Tachezy J. 2020 Ananerobic peroxisomes in Mastigamoeba balamuthi. Proc Natl Acad Sci U S A. 117(4):2065-2075. doi: 10.1073/pnas.1909755117. Epub 2020 Jan 13.
2019
Rada P., Makki A., Tachezy J. 2019 Targeting of C-tail anchored proteins to Trichomonas vaginalis hydrogenosomes. Mol. Microbiol. 111(3):588-603. doi: 10.1111/mmi.14175. [Epub ahead of print].
Makki A., Rada P, Žárský V., Kereiche S., Kovacik L., Novotny M., Jores T., Rapaport D., Tachezy J. 2019 Triplet-pore structure of a highly divergent TOM complex of hydrogenosomes in Trichomonas vaginalis. PLoS Biology. 17(1):e3000098. doi: 10.1371/journal.pbio.3000098.
Rada P., Kellerová P., Verner Z. and Tachezy J. 2019. Investigation of the secretory pathway in Trichomonas vaginalis argues against a moonlighting function of hydrogenosomal enzymes. Journal of Eukaryotic Microbiology,
2018
Štáfková J., Rada P., Meloni D., Žárský V., Smutná T., Zimmann N., Harant K., Pompach P., Hrdý I., Tachezy J. 2018. Dynamic secretome of Trichomonas vaginalis: Case study of β-amylases. Molecular and Cellular Proteomics, 2018 Feb;17(2):304-320. doi: 10.1074/mcp.RA117.000434,
Barlow L.D., Nývltová E., Aguilar A., Tachezy J., Dacks J. B. 2018 A sophisticated, differentiated Golgi in the ancestor of eukaryotes. BMC Biology, 16(1):27. doi: 10.1186/s12915-018-0492-9
Priscila Peña-Diaz, Jan Mach, Eva Kriegová, Pavel Poliak, Jan Tachezy and Julius Lukeš. 2018. Trypanosomal mitochondrial intermediate peptidase does not behave as a classical mitochondrial processing peptidase. PLoS One 13(4):e0196474. doi: 10.1371/journal.pone.0196474.
2017
Kellerová, P., Tachezy J. 2017 Zoonotic Trichomonas tenax, and Trichomonas brixi n. sp., a new trichomonad species from the oral cavities of dogs and cats. International Journal for Parasitology. ;47(5):247-255. doi: 10.1016/j.ijpara.2016.12.006. Epub 2017 Feb 24.accepted.
Nývltová, E., Šuťák R., Žárský V., Harant K., Hrdý I., Tachezy J. 2017. Lateral gene transfer of p-cresol- and indole-producing enzymes from environmental bacteria to Mastigamoeba balamuthi. Environmental Microbiology, 2017 Mar;19(3):1091-1102. doi: 10.1111/1462-2920.13636. Epub 2017 Jan 25.PMID:27902886
Voleman L, Najdrová V, Ástvaldsson Á, Tůmová P, Einarsson E, Švindrych Z, Hagen GM, Tachezy J, Svärd SG, Doležal P. 2017. Giardia intestinalis mitosomes undergo synchronized fission but not fusion and are constitutively associated with the endoplasmic reticulum. BMC Biol.;15(1):27. doi: 10.1186/s12915-017-0361-y
2016
Eliáš M., Klimeš V., Derelle R., Petrželková R., Tachezy J. 2016 A paneukaryotic genomic analysis of the small GTPase RABL2 underscores the significance of recurrent gene loss in eukaryote evolution. Biol Direct.;11(1):5. doi: 10.1186/s13062-016-0107-8.
Nývltová E, Smutná T, Tachezy J, Hrdý I. 2016. OsmC and incomplete glycine decarboxylase complex mediate reductive detoxification of peroxides in hydrogenosomes of Trichomonas vaginalis. Mol Biol Parasitol, Jan 18. pii: S0166-6851(16)30006-8. doi: 10.1016/j.molbiopara.2016.01.006. [Epub ahead of print].
Štáfková J, Mach J, Biran M, Verner Z, Bringaud F, Tachezy J. 2016. Mitochondrial pyruvate carrier in Trypanosoma brucei. Mol. Microbiol. 100(3):442-56. doi: 10.1111/mmi.13325. Epub 2016 Feb 10.
Pyrih J, Pyrihová E, Kolísko M, Stojanovová D, Basu S, Harant K, Haindrich AC, Doležal P, Lukeš J, Roger A, Tachezy J. 2016. Minimal cytosolic iron-sulfur cluster assembly machinery of Giardia intestinalis is partially associated with mitosomes. Mol. Microbiol. 102:701-714. doi: 10.1111/mmi.13487.