Malych R, Folgosa F, Pilátová J, Mikeš L, Dohnálek V, Mach J, Matějková M, Kopecký V, Doležal P, Sutak R. Eating the brain - A multidisciplinary study provides new insights into the mechanisms underlying the cytopathogenicity of Naegleria fowleri. PLoS Pathog. 2025
Ženíšková K, Stopka P, Martín-Pérez T, Chevreux G, Grechnikova M, Drncová E, Malych R, Mach J, Walochnik J, Camadro JM, Sutak R. Molecular Mechanisms of Acanthamoeba castellanii Response to Different Sources of Oxidative Stress. J Proteome Res. 2025
Rmaña-Molina M, Piñero JE, Lorenzo-Morales J. Staurosporine as a Potential Treatment for Acanthamoeba Keratitis Using Mouse Cornea as an Ex Vivo Model. Mar Drugs. 2024
Arbon D, Mach J, Čadková A, Sipkova A, Stursa J, Klanicová K, Machado M, Ganter M, Levytska V, Sojka D, Truksa J, Werner L, Sutak R. Chelation of Mitochondrial Iron as an Antiparasitic Strategy. ACS Infect Dis. 2024
Del Campo J, Carlos-Oliveira M, Čepička I, Hehenberger E, Horák A, Karnkowska A, Kolisko M, Lara E, Lukeš J, Pánek T, Piwosz K, Richter DJ, Škaloud P, Sutak R, Tachezy J, Hampl V. The protist cultural renaissance. Trends Microbiol. 2024
Grechnikova M, Füssy Z, Sutak R. Copper in parasitic protists - a hitherto neglected virulence factor. Trends Parasitol. 2024
Rodríguez-Expósito RL, Sifaoui I, Salazar-Villatoro L, Bethencourt-Estrella CJ, Fernández JJ, Díaz-Marrero AR, Sutak R, Omaña-Molina M, Piñero JE, Lorenzo-Morales J. Staurosporine as a Potential Treatment for Acanthamoeba Keratitis Using Mouse Cornea as an Ex Vivo Model. Mar Drugs. 2024
Rodríguez-Expósito RL, Sifaoui I, Reyes-Batlle M, Fuchs F, Scheid PL, Piñero JE, Sutak R, Lorenzo-Morales J. Induction of Programmed Cell Death in Acanthamoeba culbertsoni by the Repurposed Compound Nitroxoline. Antioxidants (Basel). 2023
Motyčková A, Voleman L, Najdrová V, Arbonová L, Benda M, Dohnálek V, Janowicz N, Malych R, Šuťák R, Ettema TJG, Svärd S, Stairs CW, Doležal P. Adaptation of the late ISC pathway in the anaerobic mitochondrial organelles of Giardia intestinalis. PLoS Pathog. 2023
Ženíšková K, Mach J, Arbon D, Štursa J, Werner L, Zoltner M, Sutak R. The 4-Aminomethylphenoxy-Benzoxaborole AN3057 as a Potential Treatment Option for Primary Amoebic Meningoencephalitis. Antimicrob Agents Chemother. 2023
Kazamia E, Mach J, McQuaid JB, Gao X, Coale TH, Malych R, Camadro JM, Lesuisse E, Allen AE, Bowler C, Sutak R. In vivo localization of iron starvation induced proteins under variable iron supplementation regimes in Phaeodactylum tricornutum. Plant Direct. 2022
Arbon D, Ženíšková K, Šubrtová K, Mach J, Štursa J, Machado M, Zahedifard F, Leštinová T, Hierro-Yap C, Neuzil J, Volf P, Ganter M, Zoltner M, Zíková A, Werner L, Sutak R. Repurposing of MitoTam: Novel Anti-Cancer Drug Candidate Exhibits Potent Activity against Major Protozoan and Fungal Pathogens. Antimicrob Agents Chemother. 2022
Ženíšková K, Grechnikova M, Sutak R. Copper Metabolism in Naegleria gruberi and Its Deadly Relative Naegleria fowleri. Front Cell Dev Biol. 2022
Grechnikova M, Arbon D, Ženíšková K, Malych R, Mach J, Krejbichová L, Šimáčková A, Sutak R. Elucidation of iron homeostasis in Acanthamoeba castellanii. Int J Parasitol. 2022
Malych R, Füssy Z, Ženíšková K, Arbon D, Hampl V, Hrdý I, Sutak R. The response of Naegleria gruberi to oxidative stress. Metallomics. 2022
Smutná T, Dohnálková A, Sutak R, Narayanasamy RK, Tachezy J, Hrdý I. A cytosolic ferredoxin-independent hydrogenase possibly mediates hydrogen uptake in Trichomonas vaginalis. Curr Biol. 2022
Malych R, Stopka P, Mach J, Kotabová E, Prášil O, Sutak R. Flow cytometry-based study of model marine microalgal consortia revealed an ecological advantage of siderophore utilization by the dinoflagellate Amphidinium carterae. Comput Struct Biotechnol J. 2022
Kotabova E, Malych R, Pierella Karlusich JJ, Kazamia E, Eichner M, Mach J, Lesuisse E, Bowler C, Prášil O, Sutak R. Complex Response of the Chlorarachniophyte Bigelowiella natans to Iron Availability. mSystems. 2021
Sutak R, Camadro JM, Lesuisse E. Iron Uptake Mechanisms in Marine Phytoplankton. Front Microbiol. 2020
Grechnikova M, Ženíšková K, Malych R, Mach J, Sutak R. Copper detoxification machinery of the brain-eating amoeba Naegleria fowleri involves copper-translocating ATPase and the antioxidant system. Int J Parasitol Drugs Drug Resist. 2020
Mach J, Sutak R. Iron in parasitic protists - from uptake to storage and where we can interfere. Metallomics. 2020
Arbon D, Ženíšková K, Mach J, Grechnikova M, Malych R, Talacko P, Sutak R. Adaptive iron utilization compensates for the lack of an inducible uptake system in Naegleria fowleri and represents a potential target for therapeutic intervention. PLoS Negl Trop Dis. 2020
Sarink MJ, Tielens AGM, Verbon A, Sutak R, van Hellemond JJ. Inhibition of fatty acid oxidation as a new target to treat Primary Amoebic Meningoencephalitis. Antimicrob Agents Chemother. 2020
Bae DH, Lane DJR, Siafakas AR, Sutak R, Paluncic J, Huang MLH, Jansson PJ, Rahmanto YS, Richardson DR. Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone. Biochim Biophys Acta Mol Basis Dis. 2020
Scheiber IF, Pilátová J, Malych R, et al. Copper and iron metabolism in Ostreococcus tauri - the role of phytotransferrin, plastocyanin and a chloroplast copper-transporting ATPase. Metallomics. 2019
Mach J, Bíla J, Ženíšková K, Arbon D, Malych R, Glavanakovová M, Nývltová E, Sutak R. Iron economy in Naegleria gruberi reflects its metabolic flexibility. Int J Parasitol. 2018
Kazamia E, Sutak R, Paz-Yepes J, Dorrell RG, Vieira FRJ, Mach J, Morrissey J, Leon S, Lam F, Pelletier E, Camadro JM, Bowler C, Lesuisse E. Endocytosis-mediated siderophore uptake as a strategy for Fe acquisition in diatoms. Sci Adv. 2018
Botebol H, Lelandais G, Six C, Lesuisse E, Meng A, Bittner L, Lecrom S, Sutak R, Lozano J-C, Schatt P, Vergé V, Blain S, Bouget F-Y. Acclimation of a low iron adapted Ostreococcus strain to iron limitation through cell biomass lowering. Scientific Reports 2017
Nývltová E, Šut'ák R, Žárský V, Harant K, Hrdý I, Tachezy J. Lateral gene transfer of p-cresol- and indole-producing enzymes from environmental bacteria to Mastigamoeba balamuthi. Environ Microbiol. 2017
Lelandais G, Scheiber I, Paz-Yepes J, Lozano JC, Botebol H, Pilátová J, Žárský V, Léger T, Blaiseau PL, Bowler C, Bouget FY, Camadro JM, Sutak R, Lesuisse E. Ostreococcus tauri is a new model green alga for studying iron metabolism in eukaryotic phytoplankton. BMC Genomics. 2016
Botebol H, Lesuisse E, Šuták R, Six C, Lozano JC, Schatt P, Vergé V, Kirilovsky A, Morrissey J, Léger T, Camadro JM, Gueneugues A, Bowler C, Blain S, Bouget FY. Central role for ferritin in the day/night regulation of iron homeostasis in marine phytoplankton. Proc Natl Acad Sci U S A. 2015
Morrissey J, Sutak R, Paz-Yepes J, Tanaka A, Moustafa A, Veluchamy A, Thomas Y, Botebol H, Bouget FY, McQuaid JB, Tirichine L, Allen AE, Lesuisse E, Bowler C. A novel protein, ubiquitous in marine phytoplankton, concentrates iron at the cell surface and facilitates uptake. Curr Biol. 2015
Tsaousis AD, Nyvltová E, Sutak R, Hrdy I, Tachezy J. A nonmitochondrial hydrogen production in Naegleria gruberi. Genome Biol Evol. 2014
Pyrih J, Harant K, Martincová E, Sutak R, Lesuisse E, Hrdý I, Tachezy J. Giardia intestinalis incorporates heme into cytosolic cytochrome b₅. Eukaryot Cell. 2014
Botebol H, Sutak R, Scheiber IF, Blaiseau PL, Bouget FY, Camadro JM, Lesuisse E. Different iron sources to study the physiology and biochemistry of iron metabolism in marine micro-algae. Biometals. 2014
Nývltová E, Šuták R, Harant K, Šedinová M, Hrdy I, Paces J, Vlček Č, Tachezy J. NIF-type iron-sulfur cluster assembly system is duplicated and distributed in the mitochondria and cytosol of Mastigamoeba balamuthi. Proc Natl Acad Sci U S A. 2013
Mach J, Tachezy J, Sutak R. Efficient iron uptake via a reductive mechanism in procyclic Trypanosoma brucei. J Parasitol. 2013
Sutak R, Botebol H, Blaiseau PL, Léger T, Bouget FY, Camadro JM, Lesuisse E. A comparative study of iron uptake mechanisms in marine microalgae: iron binding at the cell surface is a critical step. Plant Physiol. 2012
Sutak R, Seguin A, Garcia-Serres R, Oddou JL, Dancis A, Tachezy J, Latour JM, Camadro JM, Lesuisse E. Human mitochondrial ferritin improves respiratory function in yeast mutants deficient in iron-sulfur cluster biogenesis, but is not a functional homologue of yeast frataxin. Microbiologyopen. 2012
Sutak R, Hrdy I, Dolezal P, Cabala R, Sedinová M, Lewin J, Harant K, Müller M, Tachezy J. Secondary alcohol dehydrogenase catalyzes the reduction of exogenous acetone to 2-propanol in Trichomonas vaginalis. FEBS J. 2012
Morada M, Smid O, Hampl V, Sutak R, Lam B, Rappelli P, Dessì D, Fiori PL, Tachezy J, Yarlett N. Hydrogenosome-localization of arginine deiminase in Trichomonas vaginalis. Mol Biochem Parasitol. 2011
Sutak R, Slapeta J, San Roman M, Camadro JM, Lesuisse E. Nonreductive iron uptake mechanism in the marine alveolate Chromera velia. Plant Physiol. 2010
Seguin A, Sutak R, Bulteau AL, Garcia-Serres R, Oddou JL, Lefevre S, Santos R, Dancis A, Camadro JM, Latour JM, Lesuisse E. Evidence that yeast frataxin is not an iron storage protein in vivo. Biochim Biophys Acta. 2010
Rada P, Smíd O, Sutak R, Dolezal P, Pyrih J, Zársky V, Montagne JJ, Hrdy I, Camadro JM, Tachezy J. The monothiol single-domain glutaredoxin is conserved in the highly reduced mitochondria of Giardia intestinalis. Eukaryot Cell. 2009
Peslova G, Petrak J, Kuzelova K, Hrdy I, Halada P, Kuchel PW, Soe-Lin S, Ponka P, Sutak R, Becker E, Huang ML, Suryo Rahmanto Y, Richardson DR, Vyoral D. Hepcidin, the hormone of iron metabolism, is bound specifically to alpha-2-macroglobulin in blood. Blood. 2009
Whitnall M, Suryo Rahmanto Y, Sutak R, Xu X, Becker EM, Mikhael MR, Ponka P, Richardson DR. The MCK mouse heart model of Friedreich's ataxia: Alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation. Proc Natl Acad Sci U S A. 2008
Sutak R, Lesuisse E, Tachezy J, Richardson DR. Crusade for iron: iron uptake in unicellular eukaryotes and its significance for virulence. Trends Microbiol. 2008
Long S, Jirků M, Mach J, Ginger ML, Sutak R, Richardson D, Tachezy J, Lukes J. Ancestral roles of eukaryotic frataxin: mitochondrial frataxin function and heterologous expression of hydrogenosomal Trichomonas homologues in trypanosomes. Mol Microbiol. 2008
Sutak R, Xu X, Whitnall M, Kashem MA, Vyoral D, Richardson DR. Proteomic analysis of hearts from frataxin knockout mice: marked rearrangement of energy metabolism, a response to cellular stress and altered expression of proteins involved in cell structure, motility and metabolism. Proteomics. 2008
Xu X, Sutak R, Richardson DR. Iron chelation by clinically relevant anthracyclines: alteration in expression of iron-regulated genes and atypical changes in intracellular iron distribution and trafficking. Mol Pharmacol. 2008
Dolezal P, Dancis A, Lesuisse E, Sutak R, Hrdý I, Embley TM, Tachezy J. Frataxin, a conserved mitochondrial protein, in the hydrogenosome of Trichomonas vaginalis. Eukaryot Cell. 2007
Dolezal P, Smíd O, Rada P, Zubácová Z, Bursać D, Suták R, Nebesárová J, Lithgow T, Tachezy J. Giardia mitosomes and trichomonad hydrogenosomes share a common mode of protein targeting. Proc Natl Acad Sci U S A. 2005
Babusiak M, Man P, Sutak R, Petrak J, Vyoral D. Identification of heme binding protein complexes in murine erythroleukemic cells: study by a novel two-dimensional native separation -- liquid chromatography and electrophoresis. Proteomics. 2005
Sutak R, Chamot C, Tachezy J, Camadro JM, Lesuisse E. Siderophore and haem iron use by Tritrichomonas foetus. Microbiology. 2004
Sutak R, Dolezal P, Fiumera HL, Hrdy I, Dancis A, Delgadillo-Correa M, Johnson PJ, Müller M, Tachezy J. Mitochondrial-type assembly of FeS centers in the hydrogenosomes of the amitochondriate eukaryote Trichomonas vaginalis. Proc Natl Acad Sci U S A. 2004
Sutak R, Tachezy J, Kulda J, Hrdý I. Pyruvate decarboxylase, the target for omeprazole in metronidazole-resistant and iron-restricted Tritrichomonas foetus. Antimicrob Agents Chemother. 2004
Land KM, Delgadillo-Correa MG, Tachezy J, Vanacova S, Hsieh CL, Sutak R, Johnson PJ. Targeted gene replacement of a ferredoxin gene in Trichomonas vaginalis does not lead to metronidazole resistance. Mol Microbiol. 2004
Zoldák G, Sut'ák R, Antalík M, Sprinzl M, Sedlák E. Role of conformational flexibility for enzymatic activity in NADH oxidase from Thermus thermophilus. Eur J Biochem. 2003
Tovar J, León-Avila G, Sánchez LB, Sutak R, Tachezy J, van der Giezen M, Hernández M, Müller M, Lucocq JM. Mitochondrial remnant organelles of Giardia function in iron-sulphur protein maturation. Nature. 2003
Suchan P, Vyoral D, Petrák J, Sut'ák R, Rasoloson D, Nohýnková E, Dolezal P, Tachezy J. Incorporation of iron into Tritrichomonas foetus cell compartments reveals ferredoxin as a major iron-binding protein in hydrogenosomes. Microbiology. 2003