What is the purpose of the study?

The purpose of this study is to examine how different combinations of dietary protein, fibre, probiotics, a proprietary postbiotic (AEP-3), and a botanical ingredient (BG3) influence gut microbial composition and activity. 

Why is this study important?

This study is important because it will help identify how specific combinations of nutrients and bioactive ingredients can beneficially modulate the gut microbiome, potentially reducing harmful bacteria and supporting beneficial ones. These insights could guide the development of effective dietary supplements and strategies to improve gut health.

What type of study is this?

This is a laboratory-based ex vivo experimental study. Stool samples from participants are collected and then tested in a controlled laboratory setting to simulate the anaerobic environment of the human colon. The study investigates how different ingredient combinations affect the microbial community and its metabolic activity outside the body, using participants’ stool samples.

How long will I be involved in this study?

Participants’ involvement is brief and limited to providing a stool sample. There is no long-term participation, as the experimental work is carried out entirely in the laboratory on the collected samples.

What will happen to any samples I give?

The samples you provide will be used only for this study. They will be securely stored and may be analyzed for related research in the future in compliance with ethical and regulatory guidelines. Specimens will be processed at Monash University Malaysia. Unprocessed samples will be securely stored at -80°C at the earliest opportunity. All specimens and data will be handled in compliance with ethical and regulatory guidelines, ensuring the utmost confidentiality and security.

At the end of the study, any remaining samples may be retained for future research for seven (7) years, subject to your consent. Specimens no longer required will be destroyed following institutional policies to ensure proper disposal.

Will my medical information be kept private?

All information obtained in the study will be kept and handled in a confidential manner, in accordance with applicable laws and/or regulations. This study has been approved by the Monash University Human Research Ethics Committee (MUHREC) [Project ID: 47462]. Only researchers involved in this study will access your data while your study data will be securely stored in password protected spreadsheets. DNA sequencing data deposited in GenBank for research purposes. When publishing or presenting the study results, your identity will not be revealed without your expressed consent. 

Will I be informed of the study findings?

The overall study results will not be informed to you. However, it may be available in the form of journal publication.

Who should I contact if I have questions?

If you have any questions about the study, you may contact Associate Professor Dr Chong Chun Wie (ChongChunWie@monash.edu) for further information.