Embedded Files
Figure 1. Ethanol Consumption
Figure 1. Ethanol Consumption
Consumption of 15% EtOH. Mice increased EtOH drinking over 10 sessions, but consumption was not affected by treatment. **** p < 0.0001 main effect (two-way repeated-measures ANOVA).
Figure 2. Preference
Figure 2. Preference
Preference for 15% EtOH vs water. Mice increased preference for EtOH over sessions, but it was not affected by treatment. **** p < 0.0001 main effect (two-way repeated-measures ANOVA).
Figure 3. Water Consumption
Figure 3. Water Consumption
Consumption of water. There was no difference in water consumption over sessions, and consumption was not affected by treatment. (two-way repeated-measures ANOVA).
Future Directions
Future Directions
Conclude drinking in the dark protocol and aversion resistance paradigm in female mice
Confirm placement of viral knockdown in the mPFC
Run procedures in male mice to assess the contribution of Gprasp1 shRNA knockdown and compare to females to examine sex differences in alcohol drinking
Investigate additional brain regions influenced by Gprasp1 overexpression
Conclusions
Conclusions
In the first two weeks of DID, consumption and preference for ethanol increased over sessions.
Consumption or preference did not differ between treatment groups.
Current findings do not show a difference in water consumption over sessions.
Completion of the study and further research is necessary for understanding the role of Gprasp1 shRNA knockdown in the mPFC.
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