The KM Lab (Meemon Lab) investigates the biological mechanisms that drive aging, metabolic health, and neurodegenerative diseases using C. elegans as a powerful model system. Our research focuses on identifying natural compounds and molecular pathways that promote longevity, protect neuronal function, and improve metabolic balance. By integrating genetics, molecular biology, and advanced imaging, we aim to develop innovative strategies for delaying aging and preventing age-associated diseases.
Our Mission is o advance fundamental understanding of aging, metabolism, and neurodegeneration and to develop novel therapeutic strategies—particularly natural product–based interventions—that improve healthspan and protect against age-related diseases.
We are a research team specializing in Caenorhabditis elegans, a small soil-dwelling nematode widely used as a model organism in biomedical sciences. Many of the genes and molecular pathways that regulate human development, physiology, and disease are evolutionarily conserved in C. elegans, making it a powerful system for studying fundamental biology. Our research focuses on aging, age-related disorders, and neurodegenerative diseases, with the goal of uncovering mechanisms that drive these conditions and identifying strategies for prevention and intervention.
Pathways regulating lifespan (insulin/IGF-1, mTOR, AMPK, mitochondrial function)
Cellular stress resistance and proteostasis
Biomarkers of healthspan
C. elegans models of Alzheimer’s and Parkinson’s
Neuronal survival, misfolded protein toxicity, and neuronal function
Neuroprotective bioactives and disease-modifying mechanisms
Lipid metabolism, energy balance, and fat-storage regulation
Natural compounds with anti-obesity or metabolic-improving effects
Plant extracts, phytochemicals, and novel bioactives
Screening pipelines for anti-aging, neuroprotection, and metabolic benefits
Albert Einstein College of Medicine, USA
Umeå University, Sweden