Relevant Articles

1. “A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice”

Abrams, M. J.; Tan, F. H.; Li, Y.; Basinger, T.; Heithe, M. L.; Sarma, A.; Lee, I. T.; Condiotte, Z. J.; Raffiee, M.; Dabiri, J. O.; Gold, D. A.; Goentoro, L. A Conserved Strategy for Inducing Appendage Regeneration in Moon Jellyfish, Drosophila, and Mice. Elife 2021, 10. https://doi.org/10.7554/eLife.65092.

1. • This paper uses 3 model organisms – mice, drosophila, and the moon jellyfish aurelia– to investigate the question, can appendage regeneration be induced, which is very similar to the question I intend to ask of how can appendage regeneration be enhanced/improved. It finds that nutrient supplementation with L-leucine and insulin can induce regeneration in animals that do not typically regenerate.

2. “Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration”

   • Sousounis, K.; Bryant, D. M.; Martinez Fernandez, J.; Eddy, S. S.; Tsai, S. L.; Gundberg, G. C.; Han, J.; Courtemanche, K.; Levin, M.; Whited, J. L. Eya2 Promotes Cell Cycle Progression by Regulating DNA Damage Response during Vertebrate Limb Regeneration. Elife 2020, 9. https://doi.org/10.7554/eLife.51217.

   • Discusses a gene, Eya2, that is upregulated in regenerating cells and critically involved in the DNA damage response process in axolotls. As DDR is shown to be a crucial mechanism of regeneration, genes associated with DDR are centrally involved in tissue renewal. The data indicated that highly-regenerative animals employ a robust DNA damage response pathway to facilitate proper cell cycle progression upon injury. As such, looking to enhance the DNA damage response pathway in drosophila may enable improved regeneration

3. “Model systems for regeneration: Drosophila”

   • Fox, D. T.; Cohen, E.; Smith-Bolton, R. Model Systems for Regeneration: Drosophila. Development 2020, 147 (7), https://doi.org/10.1242/dev.173781

   • This review paper summarizes the recent research findings and techniques for studies of regeneration in drosophila. It also highlights the advantages and uses of drosophila as a model organism.

4. “JNK Signaling Pathway Is Required for Efficient Wound Healing in Drosophila”

• Rämet, M., Lanot, R., Zachary, D., & Manfruelli, P. (2002). JNK signaling pathway is required for efficient wound healing in Drosophila. Developmental biology, 241(1), 145–156. https://doi.org/10.1006/dbio.2001.0502

• This study illuminates some of the genetic/molecular mechanisms (JNK signaling pathway) behind wound closure in drosophila imaginal discs. Wound closure and reepithelization is critical to regeneration, so these same genetic forces will, presumably, be at play in appendage regeneration as well.