Lung cancer, with non-small cell lung cancer (NSCLC) being the most prevalent form, is the leading cause of cancer-related deaths globally. There are treatment options to combat this cancer, however, they are inneffective and most of the time result in the cancer reaching a persister and tolderance state. So this calls for an important focus on research in this field to save lives and improve the wellbeing of patients.
NSCLC is commonly known for mutating, and this poses significant challenges in treatment due to its complexity, and the mechanisms that drive tumor progression, as well as resistance to therapy.
A critical focus in NSCLC research is understanding the molecular pathways underlying tumor progression. Therapies for these cells (TKIs) are often inhibited by treatment resistance, and the cells enter a state known as DTP (drug-tolerant persister), reducing the survival rate of patients. Working to determine whether MALAT1, a lncRNA, plays a role in these cells entering the DTP state and consequently leading to drug resistance, is essential for the understanding of NSCLC and effectiveness of therapies.