Cancer metabolism

It is well known that cancer cells rewire their metabolism to obtain a survival advantage in nutrient-deprived conditions. In particular, cancer cells are notorious for upregulating various metabolic pathways for nutrient scavenging, such as autophagy or macropinocytosis. Also, these cells can regulate nutrient transporters to gain a survival advantage or repgrogram the tumor microenvironment. We are interested in studying the underlying mechanisms for these reprogrammed metabolic pathways and further exploiting them for therapeutic treatments.

Ferroptosis

Initiating cell death in cancer is the ultimate goal of many cancer therapeutics. Ferroptosis is a non-apoptotic cell death program that is caused by lipid peroxidation in an iron-dependent manner. We are interested in studying the mechanism of ferroptosis and its regulation in disease states such as cancer or degenerative diseases.