Publication

2024

48. Discovery and Characterization of Selective, First-in-Class Inhibitors of Citron Kinase

Maw, J.; Coker, J. A.; Arya, T.; Goins, C. M.; Sonawane, D. P.; Han, S. H.; Rees, M. G.; Ronan, M. M.; Roth, J. A.; Wang, N. S.; Heemers, H. V.; Macdonald, J. D.; Stauffer, S. R.* 

J. Med. Chem. 2024, 67, 2631–2666.

2023

47. SARS-CoV-2 3CL-protease inhibitors derived from ML300: investigation of P1 and replacements of the 1,2,3-benzotriazole

Hooper, A.; Macdonald, J. D.; Reilly, B.; Maw, J.; Wirrick, A. P.; Han, S. H.; Lindsey, A. A.; Rico, E. G.; Romigh, T.; Goins, C. M.; Wang, N. S.; Stauffer, S. R.* 

Med. Chem. Res. 2023, 32, 1383-1390.

2022

46. C-H Amidation of 2-Aryl Azlactones Under Iridium(III) Catalysis: Access to Chiral Amino Acids

 Park, M. S.; Chung, E.; Mishra, N. K.; Han, S. H.; Han, S.; Kim, S.; Kim, I. S.* 

Chem. Commun. 2022, 58, 13365-13368.

45. Structure-based optimization of ML300 derived, non-covalent inhibitors targeting the severe acute respiratory syndrome coronavirus 3CL protease (SARS-CoV-2 3CLpro)

Han, S. H.; Goins, C. M.; Arya, T.; Shin, W.-J.; Maw, J.; Hooper, A.; Sonawane, D. P.; Porter, M. R.; Bannister, B. E.; Crouch, R. D.; Lindsey, A. A.; Lakatos, G.; Martinez, S. R.; Alvarado, J.; Akers, W. S.; Wang, N. S.; Jung, J. U.; Macdonald, J. D.; Stauffer, S. R.* 

J. Med. Chem. 2022, 65, 2880-2904.

2021

44.  A Novel Synthetic Microtubule Inhibitor Exerts Antiproliferative Effects in Multidrug Resistant Cancer Cells and Cancer Stem Cells

Park, M.; Hwang, J. W.; Cho, Y.; Kim, S.; Han, S. H.; Yu, J.; Ha, S.; Kim, W.-Y.; Kim, S.-N.; Kim, I. S.*; Kim, Y. K.* 

Sci. Rep. 2021, 11, 10822.

43. Direct Integration of Phthalazinone and Succinimide Scaffolds via Rh(III)-Catalyzed C-H Functionalization

Cho, Y. S.; Kim, H. D.; Kim, E.; Han, S. H.; Han, S. B.; Kim, H. S.; Jeong, T.; Kim, I. S.* 

Asian J. Org. Chem. 2021, 10, 202-209. (Selected as a Cover Page of AJOC)

2020

42. C2-Selective C-H Methylation of Heterocyclic N-oxides with Sulfonium Ylides

An, W.; Choi, S. B.; Kim, N.; Kwon, N. Y.; Ghosh, P.; Han, S. H.; Mishra, N. K.; Han, S.; Hong, S.; Kim, I. S.* 

Org. Lett. 2020, 22, 9004-9009.

41. Biological Evaluation of Oxindole Derivative as a Novel Anticancer Agent against Human Kidney Carcinoma Cells

Dey, P.; Kundu, A.; Han, S. H.; Kim, K.-S.; Park, J. H.; Yoon, S.; Kim, I. S.*; Kim, H. S.* 

Biomolecules 2020, 10, 1260-1282.

40. Phthalazinone-Assisted C-H Amidation Using Dioxazolones Under Rh(III) Catalysis

Jeoung, D.; Kim, K.; Han, S. H.; Ghosh, P.; Lee, S. H.; Kim, S.; An, W.; Kim, H. S.; Mishra, N. K.; Kim, I. S.* 

J. Org. Chem. 2020, 85, 7014-7023 (selected as a Cover Page of JOC).

39. Deoxygenative Amination of Azine-N-oxides with Acyl Azides via [3+2] Cycloaddition

Kim, D.; Ghosh, P.; Kwon, N. Y.; Han, S. H.; Han, S.; Mishra, N. K.; Kim, S.; Kim, I. S.* 

J. Org. Chem. 2020, 85, 2476-2485.

38. Ru(II)-Catalyzed C-H Hydroxyalkylation and Mitsunobu Cyclization of N-Aryl Phthalazinones

Kim, K.; Han, S. H.; Jeoung, D.; Ghosh, P.; Kim, S.; Kim, S. J.; Ku, J.-M.; Mishra, N. K.; Kim, I. S.* 

J. Org. Chem. 2020, 85, 2520-2531.

2019

37. Site-Selective C-H Alkylation of Diazine N-Oxides Enabled by Phosphonium Ylides 

Ghosh, P.; Kwon, N. Y.; Han, S.; Kim, S.; Han, S. H.; Mishra, N. K.; Jung, Y. H.; Chung, S. J.; Kim, I. S.* 

Org. Lett. 2019, 21, 6488-6493.

36. Allylic Acetals as Acrolein Oxonium Precursors in Tandem C-H Allylation and [3+2] Dipolar Cycloaddition

Lee, H.; Kang, D.; Han, S. H.; Chun, R.; Pandey, A. K.; Mishra, N. K.; Hong, S.; Kim, I. S.*

Angew. Chem., Int. Ed. 2019, 58, 9470-9474.

35. Synthesis of (2H)-Indazoles from Azobenzenes Using Paraformaldehyde as One Carbon Synthon

Chun, R.; Kim, S.; Han, S. H.; Han, S.; Lee, S. H.; Mishra, N. K.; Jung, Y. H.; Kim, H. S.; Kim, I. S.* 

Adv. Synth. Catal. 2019, 361, 1617-1626.

2018

34. Recent Advances in N-Heterocycles Synthesis through Catalytic C-H Functionalization of Azobenzenes

Mishra, N. K.; Park, J.; Oh, H.; Han, S. H.; Kim, I. S.* 

Tetrahedron 2018, 74, 6769-6794.

33. One-pot Synthesis of 2-Naphthols Using Nitrones and MBH Adducts via Decarboxylative N-O Bond Cleavage

 Han, S. H.; Pandey, A. K.; Lee, H.; Kim, S.; Kang, D.; Jung, Y. H.; Kim, H. S.; Hong, S.; Kim, I. S.* 

Org. Chem. Front. 2018, 5, 3210-3218. (Selected as Cover Page of OCF)

32. Site-Selective C-H Nitration of N-Aryl-7-Azaindoles Under Palladium(II) Catalysis

Chun, R.; Kim, S.; Han, S. H.; Pandey, A. K.; Mishra, N. K.; Kim, I. S.* 

Tetrahedron Lett. 2018, 59, 3848-3852.

31. Direct Synthesis of 2-Acyl Acridines Using Aldimines and Anthranils: Evaluation of Cytotoxicity and Anti-inflammatory Activity

Kim, S.; Kundu, A.; Chun, R.; Han, S. H.; Pandey, A. K.; Yoo, S.; Park, J.; Kim, H.; Ku, J.-M.; Kim, I. S.* 

Asian J. Org. Chem. 2018, 7, 2069-2075. (Selected as Cover Page of AJOC)

30. Reductive C2-Alkylation of Pyridine and Quinoline N-Oxides Using Wittig Reagents

Han, S.; Chakrasali, P; Park, J.; Oh, H.; Kim, S.; Kim, K.; Pandey, A. K.; Han, S. H.; Han, S. B.; Kim, I. S.* 

Angew. Chem., Int. Ed. 2018, 57, 12737-12740.

29. Reactivity of Morita-Baylis-Hillamn Adducts in C-H Functionalization of (Hetero)aryl Nitrones: Access to Bridged Cycles and Carbazoles 

Pandey, A. K.; Kang, D.; Han, S. H.; Lee, H.; Mishra, N. K.; Kim, H. S.; Jung, Y. H.; Hong, S.; Kim, I. S.* 

Org. Lett. 2018, 20, 4632-4636.

28. Dual Role of Anthranils as Amination and Transient Directing Group Sources: Synthesis of 2-Acyl Acridines 

Kim, S.†; Han, S. H.†; Mishra, N. K.; Chun, R.; Jung, Y. H.; Kim H. S.; Park, J. S.; Kim, I. S.* 

Org. Lett. 2018, 20, 4010-4014.

27. Ru(II)-Catalyzed C-H Aminocarbonylation of N-(Hetero)aryl-7-azaindoles with Isocyanates

Jeong, T.; Lee, S. H.; Chun, R.; Han, S.; Han, S. H.; Jeon, Y. U.; Park, J.; Yoshimitsu, T.; Mishra, N. K.; Kim, I. S.* 

J. Org. Chem. 2018, 83, 4641-4649.

26. Synthesis of (2H)-Indazoles through Rh(III)-Catalyzed Annulation Reaction of Azobenzenes with Sulfoxonium Ylides

Oh, H.; Han, S.; Pandey, A. K.; Han, S. H.; Mishra, N. K.; Kim, S.; Chun, R.; Kim, H. S.; Park, J.; Kim, I. S.*

J. Org. Chem. 2018, 83, 4070-4077.

25. Synthesis of TMPA derivatives through sequential Ir(III)-catalyzed C-H alkylation and their antidiabetic evaluation

Lee, S. H.; Kundu, A.; Han, S. H.; Mishra, N. K.; Kim, K. S.; Choi, M. H.; Pandey, A. K.; Park, J. S.; Kim, H. S.; Kim, I. S.* 

ACS Omega 2018, 3, 2661-2672.

24. Synthesis of 2-Benzazepines from Benzylamines and MBH Adducts under Rhodium(III) Catalysis via C(sp2)-H Functionalization 

Pandey, A. K.; Han, S. H.; Mishra, N. K.; Kang, D.; Lee, S. H.; Chun, R.; Hong, S.; Park, J. S.; Kim, I. S.* 

ACS Catal. 2018, 8, 742-746.

2017

23. Synthesis of Indenes that are Derived from Aldimines and Enones under Rhodium(III) Catalysis 

Han, S. H.; Kim, S.; Mishra, N. K.; Oh, H.; Choi, M. H.; Choi, D. S.; Lim, H. J.; Shin, D. Y.; Kim, I. S.* 

Asian J. Org. Chem. 2017, 6, 1823-1829.

22. Rhodium(III)-Catalyzed Diastereoselective Synthesis of 1-Aminoindanes via C-H Activation

Han, S. H.; Mishra, N. K.; Jeon, M.; Kim, S.; Kim, H. S.; Jung, S.-Y.; Jung, Y. H.; Ku, J.-M.; Kim, I. S.* 

Adv. Synth. Catal. 2017, 359, 3900-3904.

21. Synthesis and Anticancer Evaluation of 2,3-Disubstituted Indoles Derived from Azobenzenes and Internal Olefins

Oh, Y.; Han, S. H.; Mishra, N. K.; De, U.; Lee, J.; Kim, H. S.; Jung, Y. H.; Kim, I. S.* 

Eur. J. Org. Chem. 2017, 6265-6273. (Selected as VIP paper and Cover Page of EJOC, and highlighted by Synfact 2018, 14, 0014) 

20. Rh(III)-Catalyzed C-H Alkylation of Indolines with Enones through Conjugate Addition and Protonation Pathway

Oh, H.; Park, J.; Han, S. H.; Mishra, N. K.; Lee, S.; Oh, Y.; Jeon, M.; Seong, G.-J.; Chung, K. Y.; Kim, I. S.*

Tetrahedron 2017, 73, 4739-4749. (Highlighted by Synfact 2017, 13, 1015)

19. Synthesis and Anti-inflammatory Evaluation of 2-Aminobenzaldehydes via Ir(III)-Catalyzed C-H Amidation of Aldimines with Acyl Azides

Kim, S.; Chakrasali, P.; Suh, H. S.; Mishra, N. K.; Kim, T.; Han, S. H.; Kim, H. S.; Lee, B. M.; Han, S. B.; Kim, I. S.* 

J. Org. Chem. 2017, 82, 7555-7563.

18. One-pot Synthesis of Oxindoles through C-H Alkylation and Intramolecular Cyclization of Azobenzenes with Internal Olefins

Han, S. H.; Mishra, N. K.; Jo, H.; Oh, Y.; Jeon, M.; Kim, S.; Kim, W. J.; Lee, J. S.; Kim, H. S.; Kim, I. S.* 

Adv. Synth. Catal. 2017, 359, 2396-2401.

17. Synthesis and Anti-inflammatory Evaluation of N-Sulfonyl Anthranilic Acids via Ir(III)-Catalyzed C-H Amidation of Benzoic Acids

Han, S. H.; Suh, H. S.; Jo, H.; Oh, Y.; Mishra, N. K.; Han, S.; Kim, H. S.; Jung, Y. H.; Lee, B. M.; Kim, I. S.* 

Bioorg. Med. Chem. Lett. 2017, 27, 2129-2134. 

17. Synthesis and Anti-inflammatory Evaluation of N-Sulfonyl Anthranilic Acids via Ir(III)-Catalyzed C-H Amidation of Benzoic Acids

Han, S. H.; Suh, H. S.; Jo, H.; Oh, Y.; Mishra, N. K.; Han, S.; Kim, H. S.; Jung, Y. H.; Lee, B. M.; Kim, I. S.* 

Bioorg. Med. Chem. Lett. 2017, 27, 2129-2134.

16. Site-Selective Cp*Rh(III)-Catalyzed C-H Amination of Indolines with Anthranils

Mishra, N. K.; Jeon, M.; Oh, Y.; Jo, H.; Park, J.; Han, S.; Sharma, S.; Han, S. H.; Jung, Y. H.; Kim, I. S.* 

Org. Chem. Front. 2017, 4, 241-249.

2016

15. Synthesis of Succinimide-Containing Chromones, Naphthoquinones, and Xanthones under Rh(III) Catalysis: Evaluation of Anticancer Activity

Han, S. H.; Kim, S.; De, U.; Mishra, N. K.; Park, J.; Sharma, S.; Kwak, J. H.; Han, S.; Kim, H. S.; Kim, I. S.* 

J. Org. Chem. 2016, 81, 12416-12425.

14. Site-Selective C-H Amidation of Azobenzenes with Dioxazolones under Rhodium Catalysis

Mishra, N. K.; Oh, Y.; Jeon, M.; Han, S.; Sharma, S.; Han, S. H.; Um, S. H.; Kim, I. S.* 

Eur. J. Org. Chem. 2016, 4976-4980.

13. Rhodium-Catalyzed Vinylic C-H Functionalization of Enol Carbamates with Maleimides

Sharma, S.; Han, S. H.; Jo, H.; Han, S.; Mishra, N. K.; Choi, M.; Jeong, T.; Park, J.; Kim, I. S.*

Eur. J. Org. Chem. 2016, 3611-3618.

12. Cross-Coupling of Acrylamides and Maleimides under Rhodium Catalysis: Controlled Olefin Migration

Sharma, S.; Han, S. H.; Oh, Y.; Mishra, N. K.; Lee, S. H.; Oh, J. S.; Kim, I. S.*

Org. Lett. 2016, 18, 2568-2571.

11. Trifluoromethylallylation of Heterocyclic C-H Bonds with Allylic Carbonates under Rhodium Catalysis

Choi, M.; Park, J.; Sharma, S.; Jo, H.; Han, S.; Jeon, M.; Mishra, N. K.; Han, S. H.; Lee, J. S.; Kim, I. S.* 

J. Org. Chem. 2016, 81, 4771-4778.

10. Mild and Site-Selective Allylation of Enol Carbamates with Allylic Carbonates under Rhodium Catalysis

Sharma, S.; Han, S. H.; Oh, Y.; Mishra, N. K.; Han, S.; Kwak, J. H.; Lee, S.-Y.; Jung, Y. H.; Kim, I. S.* 

J. Org. Chem. 2016, 81, 2243-2251.

9. Rhodium(III)-Catalyzed Heteroatom-Directed C-H Allylation with Allylic Phosphonates and Allylic Carbonates at Room Temperature

Jo, H.; Han, S.; Park, J.; Choi, M.; Han, S. H.; Jeong, T.; Lee, S.-Y.; Kwak, J. H.; Jung, Y. H.; Kim, I. S.*

Tetrahedron 2016, 72, 571-578.

8. Access to 3-Acyl-(2H)-indazoles via Rh(III)-Catalyzed C-H Addition and Cyclization of Azobenzenes with α-Keto Aldehydes

Jeong, T.†; Han, S. H.†; Han, S.; Sharma, S.; Park, J.; Lee, J. S.; Kwak, J. H.; Jung, Y. H.; Kim, I. S.* Org. Lett. 2016, 18, 232-235.

2015

7.  Direct C-H Alkylation and Indole Formation of Anilines with Diazo Compounds under Rhodium Catalysis

Mishra, N. K.; Choi, M.; Jo, H.; Oh, Y.; Sharma, S.; Han, S. H.; Jeong, T.; Han, S.; Lee, S.-Y.; Kim, I. S.*

Chem. Commun. 2015, 51, 17229-17232. 

6. Rh(III)-Catalyzed ortho-Alkylation of N-Benzyltriflamides with Diazo Compounds

Han, S. H.; Mishra, N. K.; Kim, I. S.* 

Bull. Korean Chem. Soc. 2015, 36, 2823-2828.

5. Rhodium-Catalyzed C-H Alkylation of Indolines with Allylic Alcohols: Direct Access to β-Aryl Carbonyl Compounds

Han, S. H.; Choi, M.; Jeong, T.; Sharma, S.; Mishra, N. K.; Park, J.; Oh, J. S.; Kim, W. J.; Lee, J. S.; Kim, I. S.*

J. Org. Chem. 2015, 80, 11092-11099.

4. Rh(III)-Catalyzed Direct Coupling of Azobenzenes with α-Diazo Esters: Facile Synthesis of Cinnolin-3(2H)-ones

Sharma, S.; Han, S. H.; Han, S.; Ji, W.; Oh, J.; Lee, S.-Y.; Oh, J. S.; Jung, Y. H.; Kim, I. S.*

Org. Lett. 2015, 17, 2852-2855.

2014

3. Direct Allylation of Aromatic and α,β-Unsaturated Carboxamides under Ruthenium Catalysis

Kim, M.; Sharma, S.: Mishra, N. K.; Han, S.; Park, J.; Kim, M.; Shin, Y.; Kwak, J. H.; Han, S. H.; Kim, I. S.*

Chem. Commun. 2014, 50, 11303-11306. (Selected as Cover Page of ChemComm)

2. Copper-Catalyzed Oxidative C-O Bond Formation of 2-Acyl Phenols and 1,3-Dicarbonyl Compounds with Ethers: Direct Access to Phenol Esters and Enol Esters

Park, J.; Han, S. H.; Sharma, S.; Han, S.; Shin, Y.; Mishra, N. K.; Kwak, J. H.; Lee, C. H.; Lee, J.; Kim, I. S.*

J. Org. Chem. 2014, 79, 4735-4742.

2013

1. Synthesis and C2-Functionalization of Indoles with Allylic Acetates under Rhodium Catalysis 

Kim, M.; Park, J.; Sharma, S.; Han, S.; Han, S. H.; Kwak, J. H.; Jung, Y. H.; Kim, I. S.*

Org. Biomol. Chem. 2013, 11, 7427-7434.