The word plasmodesma (plural: plasmodesmata) derives from Latin “plasms” meaning fluid and Greek “desma” meaning “bonds”. Thus, plasmodesmata interconnect plant cells, and are formed when strands of Endoplasmic Reticulum [Chapter 2: Section 5] are entrapped when the nascent cell wall is synthesized during cell division [Chapter 1: Section 5]. Generally, plasmodesmata are approximately 50 - 60 nanometers in diameter, and can have many different structural conformation including simple [Movie 1.1] or branched [Movie 1.2]. These nano-sized pores interconnect the cytoplasm between neighboring cells and as such allow for trafficking of molecules including sugars, amino acids, proteins, RNA, or other signaling agents. In inherently immobile organisms like plants, plasmodesmata could be thought of as intercellular communication hubs through which short- and long-distance signals can be transmitted.