Jindal Medi Surge [JMS] Bone cement and bone fillers are materials used in orthopedic and dental procedures to stabilize, support, or fill bone defects. They serve different purposes in various medical applications. Here's an overview of bone cement and fillers: Bone Cement: Purpose: Bone cement, often referred to as polymethylmethacrylate (PMMA), is commonly used in orthopedic procedures, such as joint replacements (e.g., hip and knee replacements). Composition: PMMA bone cement is a mixture of a powder (typically polymethylmethacrylate beads) and a liquid monomer (methyl methacrylate). Application: In joint replacement surgery, bone cement is used to fix prosthetic components to the existing bone. It provides stability and helps distribute loads between the implant and the surrounding bone. Setting Process: The powder and liquid are mixed to form a dough-like consistency, which is then applied to the bone. It undergoes an exothermic polymerization reaction, hardening into a solid mass. Bone Fillers: Purpose: Bone fillers are materials used to fill bone voids or defects. They promote bone regeneration and healing. Types: Autografts: Bone harvested from the patient's own body. Allografts: Donor bone from another individual, often cadaveric bone. Synthetic Fillers: Various synthetic materials, including ceramics, hydroxyapatite, tricalcium phosphate, and bioactive glasses. Demineralized Bone Matrix (DBM): Allograft bone that has been processed to retain growth factors. Bone Morphogenetic Proteins (BMPs): Recombinant proteins that stimulate bone formation. Applications: Bone fillers are used in various procedures, including bone grafting, spinal fusion, and treatment of bone cysts or defects. Biodegradability: Some bone fillers are designed to be gradually resorbed by the body as new bone tissue forms. Calcium Phosphate Cement: Purpose: Calcium phosphate cements are synthetic bone substitutes that can be used as injectable fillers for bone defects. Composition: Composed of calcium and phosphate compounds. Setting Process: Undergo a setting reaction in situ, transforming from a paste to a hardened material. Applications: Used in various orthopedic and dental applications, particularly in minimally invasive procedures. Hydroxyapatite Fillers: Purpose: Hydroxyapatite is a naturally occurring mineral that is used as a bone filler. It is often incorporated into synthetic bone graft materials. Composition: Similar to the mineral component of natural bone. Applications: Used in dental and orthopedic surgeries to fill bone defects and promote bone regeneration. The choice between bone cement and bone fillers depends on the specific clinical scenario, the nature of the procedure, and the surgeon's preferences. In some cases, a combination of bone cement and fillers may be used to achieve the desired outcome, such as in joint replacement surgeries with additional bone grafting for defect augmentation.

Bone Fillers (CEMENT)

418451.000 Bone Cement Stryker Full Dose 40Gms

418451.001 Bone Cement Stryker Half Dose 20Gms

418451.002 Bone Cement Stryker With Anibiotics (Shelf Life 1Year)

418451.003 Bone Cement Zimmer With Gentamicin (Shelf Life 1Year)

418451.0031 Bone Cement Depuy (Shelf Life 1Year)

418451.004 Bone Cement Depuy With Gentamicin (Shelf Life 1Year)

418451.0041 Bone Cement Palacos RG With Antibiotics

418451.005 Syringe Kit

🦴 Bone Cement & Bone Fillers — Detailed Overview

Bone cements and fillers are medical biomaterials used in orthopedic surgery to fill voids in bone, provide structural support, and help stabilize implants or repair bone defects. While often used together in clinical practice, they serve distinct roles:

• Bone Cement: Primarily used to fix implants to native bone and fill gaps around prostheses.

• Bone Fillers: Used to fill bone voids and promote new bone formation (especially in bone grafting and defect repair).

Jindal Medi Surge (JMS) manufactures and supplies bone cement and related fillers tailored for these clinical needs.

🔹 1. Bone Cement — Definition & Purpose

Orthopedic bone cement is a synthetic, injectable biomaterial that hardens quickly upon mixing and is used to:

• Anchor prosthetic implants (e.g., hip, knee, shoulder) to bone.

• Fill irregular gaps between bone surface and implant to enhance stability.

• Augment fixation in trauma or reconstructed bone regions.

Despite the name, bone cement does not chemically bond to bone; instead, it mechanically interlocks with bone trabeculae and the implant surface.

🔹 2. Jindal Medi Surge Bone Cement Products

JMS’s product catalog includes several bone cement options:

📌 Orthopedic Bone Cements

• Standard Bone Cement — PMMA base for general orthopedic applications.

• Antibiotic-Loaded Bone Cement — PMMA with added antibiotics (e.g., gentamicin) to reduce infection risk post-surgery.

📌 Formulations

• Full Dose (e.g., 40 g)

• Half Dose (e.g., 20 g)

• Cement with Antibiotics (shelf life specified, e.g., 1 year)

• Syringe Mix Kits for ease of use in the OR.

🔹 3. How Bone Cement Works

Bone cement typically consists of:

• Powder Component: Pre-polymerized polymethyl methacrylate (PMMA) beads, radio-opacifiers (like barium sulfate), and initiators.

• Liquid Monomer: Methyl methacrylate (MMA) with stabilizers and inhibitors.

When mixed, the monomer polymerizes with the powder, forming a viscous paste that hardens within minutes into a solid mass that fills bone gaps and interlocks mechanically with the bone and implant surface.

Note: Bone cement generates heat during curing (exothermic reaction), which must be managed to avoid local tissue damage.

🔹 4. Types of Bone Cement (General)

🔹 Polymethyl Methacrylate (PMMA) Cement

• Primary material in most orthopedic bone cements.

• Provides high mechanical strength and fast initial stability.

• Non-resorbable – remains permanently in place.

🔹 Antibiotic-Loaded Cement

• PMMA cement pre-loaded with antibiotics (e.g., gentamicin) to help prevent or treat infection, especially around prostheses.

🔹 Calcium Phosphate Cements (CPC)

• Used more as bone fillers — bioactive and resorbable.

• Supports bone ingrowth over time.

🔹 5. Bone Fillers — Definition & Purpose

Bone fillers are used to:

• Fill bone voids and defects from trauma, tumor resection, or congenital defects.

• Provide a scaffold for new bone growth and eventual integration with host bone tissue.

• Promote healing in spinal fusion, reconstructive surgery, and bone grafting.

Common Bone Filler Materials

• Autografts: Patient’s own bone (best osteogenic potential).

• Allografts: Donor bone processed for safety.

• Synthetic Fillers:

  • Hydroxyapatite (HA) – osteoconductive, resorbable scaffold.

  • Tricalcium Phosphate (TCP) – resorbable ceramic.

  • Calcium Phosphate Cement – injectable filler for minimally invasive use.

  • Bioactive Glasses & Composites – tailored osteoconductivity.

🔹 6. Clinical Applications

🏥 Orthopedic Uses

• Securing prosthetic implants (hip, knee, shoulder).

• Filling defects after tumor resection or fracture reduction.

• Vertebroplasty/kyphoplasty for spinal compression fractures.

• Augmenting fixation in osteoporotic bone.

🦷 Dental / Maxillofacial Uses

• Filling extraction sites, sinus lifts, and jaw bone defects.

• Improvements in implant stability and bone regeneration support.

🔹 7. Handling & Safety (JMS Guidance)

JMS’s user manual outlines key handling and storage best practices:

• Mix within recommended time to avoid premature curing.

• Use in sterile conditions; dispose of unused cement per regulations.

• Store in a cool, dry place away from sunlight.

• Follow local waste disposal and safety guidelines.

🔹 8. Key Features & Benefits

Feature Benefit

PMMA Base High mechanical strength and load distribution

Antibiotic Loading Local infection control at the surgical site

Rapid Setting Immediate stabilization of implants

Radiopaque Formulation Allows post-op imaging assessment

Versatile Application Suitable for joint replacement, trauma, and bone void filling

📌 Summary

Bone Cement and Bone Fillers are essential materials in modern orthopedic surgery:

• Bone Cement (PMMA-based) provides mechanical fixation of implants and fills bone gaps around prostheses.

• Antibiotic-Loaded Cement reduces infection risk in revision or contaminated cases.

• Bone Fillers (autograft, allograft, synthetic ceramics, CPCs) support bone regeneration and defect repair.

Jindal Medi Surge (JMS) supplies a range of orthopedic bone cements — including standard and antibiotic-loaded PMMA cements — along with supporting fillers suited for various clinical orthopedics and reconstructive procedures.