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Presence of Amyloid Beta Plaques in the Brain
Amyloid beta plaques are abnormal accumulations of a protein called amyloid beta that form in the brain. These plaques are a hallmark feature of Alzheimer's disease and are believed to play a significant role in the progression of the disease. Amyloid beta is a protein fragment that is produced naturally in the brain. In healthy individuals, it is broken down and eliminated, but in Alzheimer's disease, it accumulates and forms into plaques. These plaques can disrupt communication between nerve cells and may contribute to the death of nerve cells, leading to the cognitive decline and memory loss characteristic of Alzheimer's disease.
Elevator Pitch
Project Summary
Project Title: Investigation of Amyloid Beta Uptake in Rat Muller Cell Culture
Amyloid beta peptide, often abbreviated as Aβ, is a small protein fragment that plays a central role in the development of Alzheimer's disease, a neurodegenerative disorder. To delve into its impact in cell culture, I conducted an experiment on the amyloid beta uptake on rat Müller cells.
The purpose of the experiment is to observe the influence of amyloid beta on cells and how it fluctuates with increase in its concentration. This type of assay helps researchers understand how cells interact with and internalize specific substances, providing insights into cellular mechanisms and potential implications for diseases like Alzheimer's, where amyloid beta accumulation is a characteristic feature.
Final Project
About The Internship
About The Internship
I intern under the IU School of Medicine - Department of Ophthalmology and work for Dr. Ashay Bhatwadekar. This lab is mainly focused on rat muller cell dysfunction and the negative effects of the disrupted circadian rhythm on vision. I help conduct research on amyloid beta and in order to achieve the expected results, I have tried to understand and analyse more on this topic by going through scientific research papers, attending seminars and lab meetings, performing the required experiments and communicating with other faculty in the lab.
Workplace
Workplace
I study the presence of the peptide Amyloid Beta and its presence in Rat Muller cells and have conducted an experiment in regard to this by performing an uptake assay.
I was able to perform experiments such as growing cell culture by passaging the cells and provide related data to the lab. I was not only able to learn more about the Alzheimer's disease and its relations with amyloid beta but was also able to gain more knowledge on various subjects related to the eye while doing in vitro experiments, reading scientific research and attending seminars held by the Department of Ophthalmology.
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