Program

4 p.m. — 6 p.m.
Arrival and Check-in

6 p.m. — 7 p.m.
Dinner

7:30 p.m. — 7:40 p.m.
Introductory Comments
Partha Basu, IUPUI, USA

7:40 p.m. — 9 p.m.
Session 1: Opening Session
Chair: Russ Hille, University of California, Riverside, USA

“Aldehyde oxidoreductase from Desulfovibrio gigas in the landscape of mononuclear Molybdenum enzymes – a story”
José J.G. Moura, NOVA School of Science and Technology, Portugal

9 p.m. — 11 p.m.
Chairs Reception

7:30 a.m. — 8:30 a.m.
Breakfast

8:30 a.m. — 10:20 a.m.
Session 2
Chair: Sharon Burgmayer, Bryn Mawr College, USA

8:30 a.m. — 9 a.m.
“New Insights into Mo and W Enzyme Catalysis”
Martin Kirk, University of New Mexico, USA

9 a.m. — 9:30 a.m.
“Molybdenum Enzyme Electrochemical Communication”
Paul V. Bernhardt, University of Queensland, Australia

9:30 a.m. — 10 a.m.
"HERFD-XAS of Mo Enzymes”
Graham N. George, University of Saskatchewan, Canada

10 a.m. — 10:20 a.m.
“Mechanistic and Spectroscopic Studies of Nitrate Reductase”
Jarett Wilcoxen, University of Wisconsin-Milwaukee, USA

10:20 a.m. — 10:50 a.m.
Break

10:50 a.m. — 12:30 p.m.
Session 3
Chair: Kylie Allen, Virginia Tech, USA

10:50 a.m. — 11:20 a.m.
“Molybdate and Moco biosynthesis in the fungus Neurospora crassa”
Ralf R. Mendel, Technical University of Braunschweig, Germany

11:20 a.m. — 11:50 a.m.
“The mechanism of controlled radical initiation in radical SAM GTP 3',8-cyclase and Moco deficiency disease”
Kenichi Yokoyama, Duke University, USA

11:50 a.m. — 12:20 p.m.
"Dietary molybdenum cofactor promotes fitness by increasing Moco content and sulfite oxidase activity in the nematode C. elegans”
Kurt Warnhoff University of South Dakota, USA

12:20 p.m. — 12:40 p.m.
“Investigating the structural features of the Moco RNA Motif”
Maria Reichenbach, University of Zurich, Switzerland

12:45 p.m. — 1:45 p.m.
Lunch

1:45 p.m. — 4 p.m.
Free time

4 p.m. — 6 p.m.
Session 4: Poster Session

6 p.m. — 7:30 p.m.
Dinner

7:30 p.m. — 9:30 p.m.
Session 5
Chair: Guenter Schwarz, University of Köln, Germany

7:30 p.m. — 7:50 p.m.
“mARC2 regulates cardiomyocyte glucose uptake”
Courtney Sparacino-Watkins, University of Pittsburgh, USA

7:50 p.m. — 8:20 p.m.
"Central role of mitochondria in the pathophysiology of isolated sulfite oxidase and molybdenum cofactor deficiencies”
Guilhian Leipnitz, PPG Ciências Biológicas: Fisiol, Brazil

8:20 p.m. — 8:50 p.m.
“The mitochondrial protein sulfite oxidase (SUOX) regulates nucleolar function"
Susan Baserga, Yale University, USA

8:50 p.m. — 9:30 p.m.
Keynote 1: “The mitochondrial amidoxime reducing component (mARC) – current state of research”
Bernd Clement, Christian-Albrechts-Universität zu Kiel, Germany

9:30 p.m. —
Poster

7:30 a.m. — 8:30 a.m.
Breakfast

8:30 a.m. — 10:20 a.m.
Session 6
Chair: Paul Bernhardt, University of Queensland, Australia

8:30 a.m. — 9 a.m.
“A new twist on formate dehydrogenase family”
Axel Magalon, CNRS, Aix-Marseille University, France

9 a.m. — 9:30 a.m.
"Structure and function of tungsten aldehyde oxidoreductase from Aromatoleum aromaticum; H2 dependent reduction of organic acids"
Maciej Szaleniec, Polish Academy of Sciences, Poland

9:30 a.m. — 10 a.m.
“New Paradigms in Bioenergetics: Decoding the Unusual Redox Biochemistry of Aerobic Formate Respiration"
C. S. Raman, University of Maryland Baltimore, USA

10 a.m. — 10:20 a.m.
“Refining the inhibition and catalytic mechanism of formate dehydrogenase from Rhodobacter capsulatus"
B.R. Duffus, Universität Potsdam, Germany

10:20 a.m. — 10:50 a.m.
Break

10:50 a.m. — 12:30 p.m.
Session 7
Chair: Marcus Ribbe, University of California - Irvine, USA

10:50 a.m. — 11:20 a.m.
“Evidence of substrate binding and product release via belt-sulfur mobilization of the nitrogenase cofactor”
Yilin Hu, University of California - Irvine, USA

11:20 a.m. — 11:50 a.m.
“Tungsten may be an overlooked micronutrient for the human gut microbiome"
Gerrit Schut, University of Georgia, USA

11:50 a.m. — 12:20 p.m.
“Novel molybdenum enzymes involved in halo-oxyanion respiration"
John D. Coates, University of California - Berkeley, USA

12:20 p.m. — 12:40 p.m.
“One step forward to understand the biological reduction of CO2 to Formate by Mo/W Fdhs"
Cristiano Mota, Universidade NOVA de Lisboa, Portugal

12:30 p.m. — 1:30 p.m.
Box Lunch

1:30 p.m. — 4 p.m.
Free time

7:30 p.m. — 9:30 p.m.
Session 8
Chair: Eunsuk Kim, Brown University, USA

7:30 p.m. — 7:50 p.m.
“Development of a Pyranopterin Dithiolene Tungsten Model Complex for Tungstoenzymes”
Cassandra Gates, Bryn Mawr College, USA

7:50 p.m. — 8:20 p.m.
“A Functional Model of Perchlorate Reductase”
Nadia C. Mösch-Zanetti, University of Graz, Austria

8:20 p.m. — 8:50 p.m.
“{Moco}n, (n = 0-8): A General Formalism for Describing the Highly Covalent Molybdenum Cofactor of Sulfite Oxidase and Related Mo Enzymes"
John H. Enemark, The University of Arizona, USA

8:50 p.m. — 9:30 p.m.
Keynote 2: “Electron Transfer Through Pyranopterin: What Model Compounds Reveal"
Sharon Burgmayer, Bryn Mawr College, Bryn Mawr, USA

9:30 p.m. —
Poster

7:30 a.m. — 8:30 a.m.
Breakfast

8:30 a.m. — 10:20 a.m.
Session 9
Chair: Martin Kirk, University of New Mexico, USA

8:30 a.m. — 9 a.m.
“The bacterial formate hydrogenlyase complex: physiology, biochemistry and applications"
Frank Sargent, Newcastle University, UK

9 a.m. — 9:30 a.m.
“Good and Bad Roles of XO from XDH conversion in Mammalian Cells"
Takeshi Nishino, Nippon Medical School, Japan

9:30 a.m. — 10 a.m.
“Discovery of Human Gut Microbial Molybdenum Enzymes that Metabolize Dietary Polyphenols"
Min Woo Bae, Harvard University, USA

10 a.m. — 10:20 a.m.
“Kinetic Studies of Pyran Ring Stabilization Variants of Campylobacter jejuni NapA"
Mikayla Metzger, IUPUI, USA

10:20 a.m. — 10:50 a.m.
Break

10:50 a.m. — 12:30 p.m.
Session 10
Chair: Axel Magalon, CNRS, Aix-Marseille University, France

10:50 a.m. — 11:20 a.m.
“Molybdenum in Space and Time"
Ariel Anbar, Arizona State University, USA

11:20 a.m. — 11:50 a.m.
“Histidine ligands to [2Fe-2S]-clusters act as redox knobs impacted by the environment via H-bounds: the case of Rieske protein"
Barbara Schoepp-Cothenet, Aix Marseille University, France

11:50 a.m. — 12:20 p.m.
“Molybdenum in selenium respiration"
John F Stolz, Duquesne University, USA

12:20 p.m. — 12:40 p.m.
“Redefining the DMSO reductase superfamily and its impact on the evolution of biogeochemical cycles"
Michael Wells, Colorado State University, USA

12:30 p.m. — 1:30 p.m.
Lunch

1:30 p.m. — 4 p.m.
Free time

4 p.m. — 6 p.m.
Session 11: Poster Session

6 p.m. — 7:30 p.m.
Dinner

7:30 p.m. — 9:30 p.m.
Session 12
Chair: Nadia Mösch-Zanetti, University of Graz, Austria

7:30 p.m. — 7:50 p.m.
“Pterin-dependent control of biofilm formation in Agrobacterium tumefaciens”
Kylie D. Allen, Virginia Tech, USA

7:50 p.m. — 8:20 p.m.
“Chalcogen Atom Transfer Reactions with Biomimetic Molybdenum Complexes"
Eunsuk Kim, Brown University, USA

8:20 p.m. — 8:50 p.m.
“Development of Heterobimetallic Mo(VI)/Cu(I) Complexes as Structural and Functional Models of Mo-Cu CODH"
Stanislav Groysman, Wayne State University, USA

8:50 p.m. — 9:30 p.m.
Keynote 3: “How Nature Fertilizes the Earth – Nitrogen Fixation by Nitrogenase: Mechanism; Roles of FeMo-Cofactor CFe6 Core; and ‘Capping’ Mo and Fe Ions"
Brian M. Hoffman, Northwestern University, USA

9:30 p.m. —
Poster

7:30 a.m. — 8:30 a.m.
Breakfast

8:30 a.m. — 10:20 a.m.
Session 13
Chair: Betül Kaçar, University of Wisconsin, USA

8:30 a.m. — 9 a.m.
“Nitrogenase: Looking Inside the Black Box”
Douglas C. Rees, California Institute of Technology, USA

9 a.m. — 9:30 a.m.
"Enginneering Nitrogenases in Rhodobacter capsulatus"
Johannes G. Rebelein, MPI – Marburg, Germany

9:30 a.m. — 10 a.m.
“Lessons from the three isoforms of nitrogenase”
Oliver Einsle, University of Freiburg, Germany

10 a.m. — 10:20 a.m.
“Warning to all diazotrophs: CO kills (nitrogenase activity). Take preventative action now!”
Cedric P. Owens, Chapman University, USA

10:20 a.m. — 10:50 a.m.
Break

10:50 a.m. — 12:30 p.m.
Session 14
Chair: Barbara Schoepp-Cothenet, Aix Marseille Université, France

10:50 a.m. — 11:20 a.m.
“Formate dehydrogenases: recent progress"
Russ Hille, University of California, Riverside, USA

11:20 a.m. — 11:50 a.m.
“Genetics, physiology and ecology of ArxA-type arsenite oxidase-containing photosynthetic bacteria"
Chad Saltikov, University of California, Santa Cruz, USA

11:50 a.m. — 12:10 p.m.
Lightning talks from abstracts: TBD

12:10 p.m. — 12:30 p.m.
“What drives NO synthesis in plants? Comparison of nitrate reductases and ARCs"
Katrin Fischer-Schrader, University of Köln, Germany

12:30 p.m. — 2 p.m.
Lunch

2 p.m. — 3:30 p.m.
Session 15: Closing Session
Chair: Partha Basu, IUPUI, USA

2 p.m. — 2:30 p.m.
“Resurrecting ancient enzymes: Insights from the origins and early environments of life"
Betül Kaçar, University of Wisconsin-Madison, USA

2:30 p.m. — 3 p.m.
“Molybdenum cofactor and sulfite oxidase deficiency”
Guenter Schwarz, University of Köln, Germany

3 p.m. — 5 p.m.
Free time

5 p.m. — 9 p.m.
Museum Tour Banquet Dinner