My internship is at the Econs Lab within the Division of Endocrinology at the Indiana University School of Medicine. My lab site’s mission is to find new and effective treatment plans for patients dealing with osteoporosis and osteopetrosis. A striking reality is that more than 200 million people worldwide are affected by osteoporosis, yet the precise cellular mechanisms that regulate bone balance remain incompletely understood. Our team’s research focuses on uncovering these mechanisms and translating that knowledge into better therapeutic strategies for patients with bone disorders. This work is especially meaningful to me because it has the potential to significantly improve the quality of life for millions of individuals by advancing our understanding of bone formation and resorption.
Osteoporosis and osteopetrosis are two bone disorders that sound similar but behave in completely opposite ways. This video gives a quick, visual comparison of how each condition appears on X-rays, one marked by decreased bone density and fragility, the other by abnormally dense, marble-like bones. It’s a helpful overview for understanding their key radiographic differences before diving into the full explanation.
Hooshmand, S. (2024, September 20). Osteoporosis vs Osteopetrosis: Explained!. YouTube. https://www.youtube.com/watch?v=LjD_6uNSE4A
Research Summary
Osteopetrosis is a rare bone disorder in which bones become unusually dense but fragile due to problems with normal bone breakdown. This process is normally carried out by specialized cells called osteoclasts, which play a key role in keeping bones healthy and balanced throughout life. When osteoclasts do not function properly, old bone is not removed as it should be, leading to the complications seen in osteopetrosis. My project focused on understanding how osteoclasts work and how their function can be studied using a drug called PRT062607, which is a kinase inhibitor. By using this drug as a tool, I examined how changes in osteoclast activity help researchers better understand the mechanisms behind osteopetrosis. Visitors to my table will learn what osteoclasts are, why they are essential for bone health, and how scientists use targeted drugs to study cell function in disease. This project highlights how basic laboratory research can deepen our understanding of rare disorders and contribute to identifying novel treatments for high bone mass disorders, including osteopetrosis.
At the beginning of the internship, I was primarily a learner and observer, focused on understanding laboratory protocols, experimental design, and the overall goals of our drug research project. I made it a priority to be reliable, detail-oriented, and open to feedback, especially while developing new technical skills. As the year progressed, I became more independent and confident in executing experiments, analyzing data, and troubleshooting when procedures did not go as planned. My role shifted from needing close guidance to contributing more actively in discussions, asking critical questions about our results, and taking greater ownership of assigned tasks. Over time, I grew into a team member who could be trusted to complete responsibilities accurately and thoughtfully while supporting the overall workflow of the lab.
My contributions supported the larger goals of the lab in both foundational and project-specific ways. Through routine responsibilities such as collecting DNA samples and maintaining a clean, organized laboratory space, I helped ensure that experiments could be conducted efficiently and without contamination or procedural delays. In a research environment, organization and consistency directly affect data quality and safety, so even these seemingly routine tasks played an important role in maintaining the integrity of the lab’s work. In addition, my independent project testing the drug PRT062607 in AD02 cells for osteopetrosis contributed directly to the lab’s broader research focus on understanding and developing potential treatments for osteopetrosis. By generating data on how this drug affects cellular behavior in a disease-relevant model, my work added to the ongoing research efforts of the lab and supported its mission to better understand therapeutic strategies for this condition. Together, both my supportive and independent contributions helped move the research forward in meaningful ways.
Since the fall semester, I have grown significantly in my dependability and perseverance. While working with laboratory protocols, I have become much more confident and independent. My manager can now rely on me to complete protocols accurately and carefully with minimal supervision. This increased responsibility has helped me build trust within the lab and strengthened my attention to detail. I have also developed greater perseverance in my research work. For example, during the first round of my experiment, the results did not turn out as expected. Instead of becoming discouraged, I evaluated the possible sources of error, modified my experimental approach, and repeated the procedure. This experience taught me the importance of persistence and adaptability in scientific research, and it helped me grow more confident in troubleshooting and refining experimental methods.
One skill I would like to continue developing is building professional relationships. During my internship, I often become very focused on completing my procedures and experiments, which sometimes limits the amount of time I spend interacting with peers and colleagues in the lab. Moving forward, I plan to be more intentional about engaging with others in my research environment. This may include asking more questions about their projects, discussing ideas during lab meetings, and collaborating more actively with teammates. Strengthening these connections will help me learn from others, improve my communication skills, and become a more collaborative researcher.
Experiencing these concepts outside of the classroom has made the material from my biology courses more meaningful and practical. It has shown me how the foundational knowledge I learn in class connects to real-world medical research and has strengthened my interest in pursuing a career in the medical field.