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How does treatment work?
How does treatment work?
Only current treatment for Celiac disease is a gluten free diet that is life-long. When first diagnosed if the symptoms are severe corticosteroids can be used.
Removing gluten from the diet results in no more inflammation in the small intestine.
This treatment is a huge life style change and can have an effect on the mental health and quality of life on people with celiac disease.
Even people with little symptoms from celiac disease have a similar amount of mental burden to those with more severe symptoms
It is recommended to adopt healthy coping skills when living with this disease. (Dochat et al., 2024).
Strictly adhering to the gluten free diet is highly recommended as those who do are more likely to have a higher quality of life to those who are not as strict (Nachman et al., 2010).
What contains Gluten?
What contains Gluten?
Products that contain wheat (bulgar, wheatberry, durum), barley, einkorn, rye, spelt, and triticale.
Commonly found in pasta, breading, cereals, croutons, stuffing, and soy sauce etc...
The Cell Biology of Celiac Disease
The Cell Biology of Celiac Disease
When a person with celiac disease eat gluten, it travels to the small intestine where it then enters the mucosa.
tTG (tissue transglutaminase) changes the shape of the gluten.
Then, if a person has the gene HLA-DQ2 the gluten will fit into the shape perfectly.
The t-cell (part of the immune response team) will then recognize the combination as a dangerous substance.
This results in the bodies t-cells attacking the mucosal lining of the gut (Gujral, 2012).
The overproduction of the transferring receptor CD71 in patients with celiac disease causes the movement of gliadin across the intestinal mucosa.
Gliadin: protein component in gluten
In normal people, gliadin can get broken down
people with celiac's can't breakdown gliadin
(Gujral, 2012)
How is The Glucose Na+ Symport is Effected by Celiac Disease?
How is The Glucose Na+ Symport is Effected by Celiac Disease?
People without Celiac's
People without Celiac's
The low glucose concentration on the apical side of the gut results in a concentration gradient forming resulting in glucose and Na+ being absorbed into the epithelium
On the basal side the epithelium, there is a high glucose concentration compared to the extracellular space which has low glucose concentration. These means glucose will passivly go to the extracellular space.
People with Celiac's
People with Celiac's
People with celiac disease can have major damage to their gut lumen. Damage to the gut lumen also damages the glucose and Na+ symports; this results in the inability to absorb nutrients that is in the gut into the cells causing malabsorption.
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