Life-Health Sciences Internship (LHSI)

Project Summary

Approximately 5% of people with Alzheimer's Disease will present symptoms before the age of 65. The LEADS (Longitudinal Early-Onset Alzheimer's Disease Study) conducts critical research in participants with Early-Onset Alzheimer's Disease (EOAD), which is significantly understudied compared to Late-Onset Alzheimer's Disease (LOAD). This study has 20 sites across the United States that are essential in understanding critical differences between EOAD, LOAD, and Cognitively Normal participants. Neurodegeneration of the brain occurs differently in each situation, and studying the differences is essential to establishing proper therapies and treatments for Alzheimer's Disease. One main way to study this disease is through cognitive testing. There are many different forms of cognitive testing that target deficits in language, attention, memory, vision, understanding, and more. Through this internship, my overall understanding of neurodegenerative cognitive testing grew significantly. I also developed many transferable skills that I can incorporate into my future career endeavors. 


Cognitive Testing and LEADS

About the Internship




The LEADS (Longitudinal Early-Onset Alzheimer's Disease Study) conducts critical research in participants with Early-Onset Alzheimer's Disease (EOAD), and has approximately 20 sites across the United States. The principal investigator for this site is Dr. Liana Apostolova. The purpose of this study is to conduct research on a group that is typically understudied. Many people with EOAD are understudied because most treatments and studies only apply to Late-Onset Alzheimer's Disease, or LOAD. However, there are significant differences between EOAD and LOAD, and one of the main goals of this study is to compare those differences. In this study, EOAD participants will be compared to LOAD participants. EOAD participants will also be compared to participants who are determined to be Clinically Normal Participants, or CN, to understand this disease more effectively.




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Explanation Speech: Cognitive Testing

I was also able to use my understanding of cognitive testing to complete a condensed presentation for my speech class. 

Career/Academic/Professional Goals

Learning

List of Abbreviations

CN: Cognitively NormalEOAD: Early-Onset Alzheimer's DiseaseLEADS: Longitudinal Early-Onset Alzheimer's Disease StudyLOAD: Late-Onset Alzheimer's Disease