7th Grade Science Extensions

Diseases

Study a Disease- Include the Causes, Symptoms, and Treatment. Specifically explain the dysfunction of the organelle involved.

Cancer Cells

New methods for cancer cell destruction:

Using DNA https://www.cancer.gov/about-cancer/treatment/types/precision-medicine/tumor-dna-sequencing

Using White Blood Cells http://www.dailymail.co.uk/health/article-2534792/Scientists-discover-destroy-cancer-cells-blood-stream.html

Using Immunotherapy https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/immunotherapy/what-is-immunotherapy.html

Diseases due to an error in a cell organelle:

Mitochondrial Disorders in General

Mitochondrial Disease Causes and Symptoms:

https://my.clevelandclinic.org/health/diseases/15612-mitochondrial-diseases

Leigh Syndrome: https://rarediseases.info.nih.gov/diseases/6877/leigh-syndrome

Lysosome Disorders in General

Tay Sachs Disease: http://www.ygyh.org/tay/whatisit.htm

Pompe Disease: https://www.pompe.com/en/patients/about/cause.aspx

Cell Membrane Disorder

Cystic Fibrosis: https://cysticfibrosisnewstoday.com/2015/03/12/the-cellular-mechanism-of-cf-the-basics/

Golgi Apparatus Disorder

Achondrogenesis Disease: https://www.thinkgenetic.com/diseases/achondrogenesis-3194/causes/56847

https://ghr.nlm.nih.gov/condition/achondrogenesis

Other Peroxisome and Golgi Disorders:

Tiniest Malfunctions in a Cell Can Cause Devastating Diseases - Institute for Systems BiologyFeb. 19, 2014: ISB researchers are studying peroxisomes, which are cellular organelles that are linked to a rare syndrome that causes progressive organ complications and infant mortality. Peroxisomes have a role in metabolizing and breaking down cellular waste. Because peroxisomes easily change shape and function according to a cell’s needs, a systems approach is necessary to help decipher that complexity.

Human Diseases Associated with Form and Function of the Golgi ComplexThe Golgi complex lies at the heart of the secretory pathway and is responsible for modifying proteins and lipids, as well as sorting newly synthesized molecules to their correct destination. As a consequence of these important roles, any changes in its ...

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