Chien-Ling Lin, Ph.D. 林倩伶 博士
Chien-Ling Lin, Ph.D. 林倩伶 博士
Associate Research Fellow, IMB
中研院分子生物研究所,副研究員
E-mail : mbcllin@gate.sinica.edu.tw
(O) 886-2-2789-9219
N420, Institute of Molecular Biology, Academia Sinica
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◆ Education
2005-2012
Doctor of Philosophy, Program in Molecular Medicine
University of Massachusetts Medical School, Worcester, MA, USA
2002-2003
Master of Science, Neuroscience
University College London, London, United Kingdom
1998-2002
Bachelor of Science, Zoology
National Taiwan University, Taipei, Taiwan
◆ Scientific Positions
2026-NOW
Associate Research Fellow
Institute of Molecular Biology, Academia Sinica, Taiwan
2017-2026
Assistant Research Fellow
Institute of Molecular Biology, Academia Sinica, Taiwan
2016-2017
Visiting Scholoar
Brown University, Providence, RI
2012-2016
Postdoctoral Research Associate
Brown University, Providence, RI
◆ Link Research highlight
High-throughput experimental and computational analysis of pre-mRNA splicing regulation
Post-transcriptional mis-regulation in diseases
Molecular and biochemical analysis of pre-mRNA splicing and translational control
◆ Publications
Journal Articles
Po-Pang Chen, Athira Saju, Chia-Chou Wu, Tzu-Han Weng, Su-Yi Tsai, Tzu-Lun Huang, Jia-Ying Su, Chien-Ling Lin, Yu-Chun Lin, See-Yeun Ting, Sheng-hong Chen and Kuo-Chiang Hsia. 2026. Cell Cycle-Specific Regulation of Centrosome Clustering Dynamics in Cancer Cells by the Multifunctional Kinesin HSET. Advanced Science, e74651. Link
Thi Ngan Giang Nguyen, Kamal Md Mostafa, Chien-Ling Lin#, and Jun-Yi Leu#. 2026. Splicing regulation and intron evolution in the short-intron ciliate model of endosymbiosis Paramecium bursaria. Nucleic Acids Research, 54(3):gkag063. (# corresponding) Link
Chaorui Duan, Luke Buerer, Cory Bowers, Allison Taggart, Mara O'Brien, Sarah Gunasekera, Chien-Ling Lin, Jing Wang, Yi Zeng, Jonathan Staley, Alger Fredericks, Sean Monaghan, Anastasia Welch, Nathaniel Clark, Daxing Gao, Nico Marr, Shen-Ying Zhang, Jean-Laurent Casanova and William Fairbrother. 2026. Defects in intron recycling suppress the antiviral response via a mechanism of intronic endogenous dsRNA. Journal of Experimental Medicine, 223(4):e20250344. Link
Hung-Lun Chiang*, Ang-Chu Huang*, Shao-Wei Pan, Jia-Ying Su, Yen-Tsung Huang and Chien-Ling Lin. 2025. Massively Parallel Splicing Assay to Examine Splicing Errors Caused by Disease-Related Intronic Variants. Journal of Visualized Experiments 223, e68984. (*contributed equally) Link
Chien-Hsin Chu, Guan-Zhu Pan, Ching-Yen Tsai, Chen-Hsin Yu, Hsin-Nan Lin, Hung-Lun Chiang, Chen Chen, Li-Ching Chen, Xuan-Dieu Pham, Chien-Ling Lin and Pei-Lin Cheng. 2025. Nuclear paxillin functions as a molecular switch for alternative splicing in neurons during a critical period of brain development. The EMBO Journal 44(21):5965–5992. Link
Jia-Ying Su*, Yun-Lin Wang*,Yu-Chi Chang, Yu-Tung Hsieh, Cheng-Han Yang, YoonSoon Kang, Yen-Tsung Huang and Chien-Ling Lin. 2025. Multiplexed Assays of Human Disease-relevant Mutations Reveal UTR Dinucleotide Composition as a Major Determinant of RNA Stability. eLife 13:RP97682. (*contributed equally) Link
Ang-Chu Huang*, Jia-Ying Su*, Yu-Jen Hung*, Hung-Lun Chiang*, Yi-Ting Chen, Yen-Tsung Huang, Chen-Hsin Albert Yu, Hsin-Nan Lin# and Chien-Ling Lin#. 2024. SpliceAPP: an interactive web server to predict splicing errors arising from human mutations. BMC Genomics. (*contributed equally, # corresponding) Link
Luke Buerer, Nathaniel E. Clark, Anastasia Welch, Chaorui Duan, Allison J. Taggart, Brittany A. Townley, Jing Wang, Rachel Soemedi, Stephen Rong, Chien-Ling Lin, Yi Zeng, Adam Katolik, Jonathan P. Staley, Masad J. Damha, Nima Mosammaparast and William G. Fairbrother. 2024. The debranching enzyme Dbr1 regulates lariat turnover and intron splicing. Nature Communications. Link
Hung-Lun Chiang*, Yi-Ting Chen*, Jia-Ying Su*, Hsin-Nan Lin, Chen-Hsin Albert Yu, Yu-Jen Hung, Yun-Lin Wang, Yen-Tsung Huang and Chien-Ling Lin. 2022. Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing. Nature Structural & Molecular Bioigy. (*contributed equally) Link
Hsiao-Jung Kao, Hung-Lun Chiang, Hsiao-Huei Chen, Pi-Chuang Fan, Yi-Fang Tu, Yen-Yin Chou, Wuh-Liang Hwu, Chien-Ling Lin, Pui-Yan Kwok and Ni-Chung Lee. 2020. De novo mutation and skewed X-inactivation in girl with BCAP31-related syndrome. Human Mutation 41:1775-1782. Link
Allison J Taggart*, Chien-Ling Lin*, Barsha Shrestha, Claire Heintzelman, Seong Won Kim and William G Fairbrother. 2017. Large-scale Analysis of Branchpoint Usage across Species and Cell Lines. Genome Research 27:639-649. (*contributed equally) Link
Yen-Tsung Huang, Su Chu, Eric B Loucks, Chien-Ling Lin, Charles B Eaton, Stephen L Buka and Karl T Kelsey. 2016. Epigenome-wide Profiling of DNA Methylation in Paired Samples of Adipose Tissue and Blood. Epigenetics 11:227236. Link
Chien-Ling Lin*, Allison J Taggart*, Kian Huat Lim*, Kamil J Cygan, Luciana Ferraris, Robbert Creton, Yen-Tsung Huang, and William G Fairbrother. 2016. RNA structure replaces the need for U2AF2 in splicing. Genome Research 26:12-23. (*contributed equally) Link
Yen-Tsung Huang, Thomas Hsu, Karl T. Kelsey and Chien-Ling Lin. 2015. Integrative analysis of micro-RNA, gene expression, and survival of glioblastoma multiforme. Genet Epidemiol. 39:134-143. Link
Moris Nechama, Chien-Ling Lin and Joel D. Richter. 2013. An unusual two-step control of CPEB destruction by Pin1. Mol Cell Biol. 33: 48-58. Link
Chien-Ling Lin, Yen-Tsung Huang and Joel D. Richter. 2012. Transient CPEB Dimerization and Translational Control. RNA 18: 1050-1061. Link
Chien-Ling Lin, Veronica Evans, Shihao Shen, Yi Xing and Joel D. Richter. 2010. The nuclear experience of CPEB: implications for RNA processing and translational control. RNA 16: 338-348. Link
Andrew C. Lin, Chin Lik Tan, Chien-Ling Lin, Laure Strochlic, Yi-Shuian Huang, Joel D. Richter and Christine E. Holt. 2009. Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development. Neural Development 4: 8. Link
Shiaw-Wei Tyan, Ming-Chi Tsai, Chien-Ling Lin, Yun-Li Ma and Eminy H. Y. Lee. 2008. Serum- and glucocorticoid-inducible kinase 1 enhances zif268 expression through the mediation of SRF and CREB1 associated with spatial memory formation. Journal of Neurochemistry 105: 820-832. Link
Yi-Shuian Huang*, Ming-Chung Kan*, Chien-Ling Lin and Joel D. Richter. 2006. CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA. EMBO Journal 25: 4865-4876. (*contributed equally) Link
Review Articles
Rachel Soemedi, Kamil J. Cygan, Christy Rhine, David T. Glidden, Allison J. Taggart, Chien-Ling Lin, Alger M. Fredericks, William G. Fairbrother. 2017. The Effects of Structure on pre-mRNA Processing and Stability. Methods 125:36-44. Link
Chien-Ling Lin, Allison J Taggart, William G Fairbrother. 2016. RNA Structure in Splicing: an Evolutionary Perspective. RNA Biol. 13:766-771. Link
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