Research areas
Membrane Biophysics (structure, mechanics, thermodynamics, electrostatics)
Membrane-protein interaction
Membrane-cholesterol-drug interaction
Membrane-synthetic nanoparticle interaction
Light-matter interaction (structure and dynamics)
Light-induced structural dynamics of biological systems
Ultrafast (up to sub-ns) optical pump - X-ray probe dynamics of soft surfaces and liquid interfaces
By using X-rays and Langmuir-Blodgett methods, we explored the self assembly of biomolecules such as lipid, protein, cholesterol and also nanoparticles having biomedical & pharmaceutical applications.
Also investigated how protein chain flexibility dramatically alters the membrane elasticity.
By using synchrotron X-rays, Langmuir-Blodgett methods, and AFM we studied the electrostatic and van der Waals interactions of synthetic graphene oxide nanoflakes with phospholipid membrane.
Various aspects of nanoparticle interaction with cell membrane and their implications in human health and their use in pharmaceutics and nanomedicine.
Warias & Giri et al., J. Synchrotron Rad. (2024)
By synchronizing fs laser pulses with synchrotron short X-ray pulses (width ~ 100 ps) we investigate the pump-probe structural dynamics of liquid surface and interfaces, and also photo-responsive molecules in cell membranes on the timescales of second till picosecond. This project is in collaboration with Kiel University in Kiel and DESY synchrotron in Hamburg, Germany.
A typical Optical pump - X-ray probe setup
Collaborators
PD Dr. Bridget Murphy, Kiel University, Germany
Prof. Olaf Magnussen, Kiel University, Germany
PD Dr. Michael Maas, Bremen University, Germany
Prof. Mark Schlossman, University of Illinois at Chicago, USA
Prof. Norifumi Yamada, KEK, Japan
Prof. Adrian Rennie, Uppsala University, Sweden
Dr. Thomas Arnold, European Spallation Source, Sweden
Prof. Mrinmay K Mukhopadhyay, SINP, Kolkata, India
Prof. Milan K Sanyal, SINP, Kolkata, India
Prof. Sajal K Ghosh, SNU, Greater Noida, India
