Organocatalysis Group
Department of Chemistry
Indian Institute of Technology Gandhinagar
Department of Chemistry
Indian Institute of Technology Gandhinagar
Introduction
Asymmetric synthesis is one of the most demanding areas of research in the pharmaceutical industry due to the importance of single enantiomers as drug molecules over racemic mixtures. Asymmetric catalysis, chiral pool synthons, and resolution processes are the major approaches in asymmetric synthesis. Among them, asymmetric catalysis is considered to be the most attractive method due to the requirement of the least quantity of chiral source. Recently, organocatalysis has emerged as a new catalytic methodology, where purely organic molecules are used to catalyze chemical reactions. Our group focuses on the development of novel organocatalysts and catalytic methodologies for the asymmetric synthesis of bioactive molecules.
Recent Publications
Singh, S.; Kumar, R.; Dubey, N.; Appayee, C.* Synthesis and Application of Chiral cis-2,5-Disubstituted Pyrrolidine Organocatalysts” Chem. Commun. 2024, 60, 8768–8771.
Mehta, R.; Kumar, R.; Singh, S.; Appayee, C.* “Asymmetric Synthesis of α-Arylcyclohexenones Catalyzed by Diphenylprolinol Silyl Ether” J. Org. Chem. 2024, 89, 10892–10902.
Kumar, R.; Maurya, V.; Avinash, A.; Appayee, C.* “Nonsilyl Bicyclic Secondary Amine Catalysts for the Asymmetric Transfer Hydrogenation of α,β-Unsaturated Aldehydes” J. Org. Chem. 2024, 89, 8586–8600.
Kumar, R.; Singh, S.; Mehta, R.; Appayee, C.* "Polystyrene-Supported Aminocatalyst Derived from Diarylprolinol for Asymmetric α-Amination of Aldehydes" Eur. J. Org. Chem. 2023, 26, e202300147.
Group Updates
Congratulations Suraj!!!...For the Best Poster Presentation Prize at XIX J-NOST 2024, IIT Gandhinagar.
Congratulations Rohtash!!!...For the Best Oral Presentation Award at FISCO−2024, MNIT, Rajasthan.
Congratulations Rohtash!!!...For Best Poster Award and 1 year free ACS membership in ACS Ignition Research Showcase.
Congratulations Ronak!!!...For Winning First Prize in The Millionaire Quiz, ACS Ignition.
Congratulations Navneet!!!… on being awarded the prestigious PMRF fellowship.
Our research work, “Polystyrene-Supported Aminocatalyst Derived from Diarylprolinol for Asymmetric α-Amination of Aldehydes” is highlighted on the front cover of Eur. J. Org. Chem. 21/2023.
Funding
Contact Us
Academic Block 4, Office 401A
Department of Chemistry
Indian Institute of Technology Gandhinagar
Palaj Campus, Gandhinagar
Gujarat - 382055, India
Email : a.chandra@iitgn.ac.in
Phone: +91 7923952462