Organocatalysis Group
Department of Chemistry
Indian Institute of Technology Gandhinagar
Organocatalysis Group
Department of Chemistry
Indian Institute of Technology Gandhinagar
Embedded Files
Department of Chemistry
Indian Institute of Technology Gandhinagar
Introduction
Introduction
Asymmetric synthesis is one of the most demanding areas of research in the pharmaceutical industry due to the importance of single enantiomers as drug molecules over racemic mixtures. Asymmetric catalysis, chiral pool synthons, and resolution processes are the major approaches in asymmetric synthesis. Among them, asymmetric catalysis is considered to be the most attractive method due to the requirement of the least quantity of chiral source. Recently, organocatalysis has emerged as a new catalytic methodology, where purely organic molecules are used to catalyze chemical reactions. Our group focuses on the development of novel organocatalysts and catalytic methodologies for the asymmetric synthesis of bioactive molecules.
Asymmetric synthesis is one of the most demanding areas of research in the pharmaceutical industry due to the importance of single enantiomers as drug molecules over racemic mixtures. Asymmetric catalysis, chiral pool synthons, and resolution processes are the major approaches in asymmetric synthesis. Among them, asymmetric catalysis is considered to be the most attractive method due to the requirement of the least quantity of chiral source. Recently, organocatalysis has emerged as a new catalytic methodology, where purely organic molecules are used to catalyze chemical reactions. Our group focuses on the development of novel organocatalysts and catalytic methodologies for the asymmetric synthesis of bioactive molecules.
Recent Publications
Recent Publications
Mehta, R.; Chande, V. D.; Appayee, C.* "Recent Applications of Aminocatalysis in Reactions of α,β-Unsaturated Aldehydes” Synlett. 2025, Accepted Manuscript.
Singh, S.; Mehta, R.; Dubey, N. N.; Appayee, C.* "Concise, Atom-Economical, and Enantiodivergent Total Synthesis of β-Lycorane via Organocatalyzed [4+2] Cycloaddition Reaction” J. Org. Chem. 2025, 90, 11962–11972.
Kumar, R.; Avinash, A.; Mehta, R.; Appayee, C.* "Nonsilyl Bicyclic Secondary Amine Catalyzed Michael Addition of Nitromethane to β,β-Disubstituted α,β-Unsaturated Aldehydes" Org. Biomol. Chem. 2025, 23, 4730-4734.
Singh, S.; Kumar, R.; Dubey, N. N.; Appayee, C.* Synthesis and Application of Chiral cis-2,5-Disubstituted Pyrrolidine Organocatalysts” Chem. Commun. 2024, 60, 8768–8771.
Mehta, R.; Kumar, R.; Singh, S.; Appayee, C.* “Asymmetric Synthesis of α-Arylcyclohexenones Catalyzed by Diphenylprolinol Silyl Ether” J. Org. Chem. 2024, 89, 10892–10902.
Group Updates
Group Updates
Congratulations, Suraj, on successfully submitting your PhD thesis.
Congratulations, Suraj, on successfully submitting your PhD thesis.
Congratulations, Dr. Rohtash Kumar, on being awarded a PhD Degree.
Congratulations, Dr. Rohtash Kumar, on being awarded a PhD Degree.
Congratulations, Suraj, for the Best Poster Presentation Prize at XIX J-NOST 2024, IIT Gandhinagar.
Congratulations, Suraj, for the Best Poster Presentation Prize at XIX J-NOST 2024, IIT Gandhinagar.
Congratulations, Rohtash, for the Best Oral Presentation Award at FISCO−2024, MNIT, Rajasthan.
Congratulations, Rohtash, for the Best Oral Presentation Award at FISCO−2024, MNIT, Rajasthan.
Congratulations, Rohtash, for the Best Poster Award and 1 year free ACS membership in the ACS Ignition Research Showcase.
Congratulations, Rohtash, for the Best Poster Award and 1 year free ACS membership in the ACS Ignition Research Showcase.
Congratulations, Ronak, for Winning First Prize in the Millionaire Quiz, ACS Ignition.
Congratulations, Ronak, for Winning First Prize in the Millionaire Quiz, ACS Ignition.
Funding
Funding
Contact Us
Contact Us
Academic Block 4, Office 401A
Department of Chemistry
Indian Institute of Technology Gandhinagar
Palaj Campus, Gandhinagar
Gujarat - 382055, India
Email : a.chandra@iitgn.ac.in
Phone: +91 7923952462
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