In recent years, non-invasive personal healthcare monitors have gained a lot of attention owing to their capability to detect human physiological signals on the go for disease management and rehabilitation. Wearable diagnostic patches with non-invasive sensors driven by AI are the future of personalized healthcare as it would help monitor real-time biological activity and enable on the spot diagnosis. These non-invasive patches need to have built-in high-performance electronics with multiple non-invasive sensors while attaining high mechanical conformability and small form factor. The development of such a robust system emphasizes the need for novel sensor design and advanced packaging technology. The aim of the proposal is to develop a surface electromyography system for detection of muscular activity on flexible substrate as a wearable patch which can span applications all the way from medical diagnostic to personal healthcare. The aim of the project is to develop healthcare based wearable devices for 24X7 monitoring of physiological signals such as EMG, ECG, pulse and BP.
Nanostructured Hydrogen Sulphide Sensor
In this work, plasma oxidation of different metallic structures to form metal/metal oxide core-shell sensors is investigated for achieving a reliable hydrogen sulfide sensor. Platinum, widely known for its catalytic nature, is plasma oxidized at optimum conditions to fabricate Pt-PtOx core-shell nanowire sensor. The Pt-PtOx sensor shows degradation in response when used for H2S sensing, which is due to surface contamination by the sulphur species. To recover the sensor, deep ultra-violet light (UV) treatment is studied as a promising recovery method for sulphur contaminated sensor surfaces. Further, plasma oxidation of tungsten nanodiscs decorated W nanowire is carried out to achieve high sensitive H2S sensor with fast response and recovery times and good response repeatability over a study span of 6 months with detection limit as low as 0.5 ppb, one of the lowest reported in literature.
Colloidal Lithography
Colloidal lithography, a simple and inexpensive method for fabricating nanostructures is explored to create nanostructures for improving the sensing characteristics of palladium-palladium oxide core-shell structure towards H2S. Using colloidal lithography, we have been able to fabricate 100 nm diameter discs on top of Pd beam, later plasma oxidized to yield core-shell device. Nanostructuring has enhanced the sensing characteristics of the palladium-palladium oxide sensor for H2S.
Gas sensor array on plastic
Motivated by the need for low cost sensors we developed a sensor array platform with integrated microheater on flexible and low-cost plastic substrate using CMOS compatible fabrication processes. The sensor array consisted of four sensors with individually controlled microheater deposited on nanogap created using electromigration process. Due to flexible nature of substrate, the bending angle dependent microheater characteristics and sensing performance show the potential of the sensor platform in low power wearable electronics.
Site Specific Immobilization of Single DNA
The work involves simulation, fabrication and characterization of nanogap electrodes for site specific binding of DNA molecules. It involves study of the behaviour of DNA under an electric field. In this project we are trying to see how the DNA can be manipulated by applying an electric field through various electrical and physical process. I have done the simulation of DNA using COMSOL Multiphysics software to see its behaviour under an applied Electric Field. The fabrication of nanogap electrodes was carried out at Centre of Excellence in Nanoscience at IIT Bombay as part of my thesis working on Jeol EBL 6400 and Raith 150 for electron beam lithography used for the devices.