Embedded Files
Tissue Engineering/Organ-on-chip models
Tissue Engineering/Organ-on-chip models
Intestine-on-a-chip
Intestine-on-a-chip
We have developed an intestine tissue chip using a novel microfluidic device that incorporates collagen membrane instead of the more typical Transwell membrane. The collagen allows establishment of a monolayer with tight junctions. We are using the device to study how the bacteria in the gut modulate activity of cytochrome P450 enzymes.
Adipose-on-a-Chip
Adipose-on-a-Chip
We have developed perfused microfluidic tissue-chips with (1) preadipocytes differentiated into adipocytes and (2) adipocytes with insulin resistance (IR). IR adipocytes displayed impaired fatty acid uptake which was rescued by treatment with rosiglitazone. These tissue-chips serve as a model for studying obesity and other metabolic disorders.
Liver-on-a-Chip
Liver-on-a-Chip
We have developed perfused microfluidic multi-cellular tissue constructs that exhibit long-term, stable function. We have established insulin resistance in the hepatocytes and have used this model to test strategies that can alleviate disrupted insulin response.
Biosensors
Biosensors
Multiplexed Cellular Analysis
Multiplexed Cellular Analysis
One of the challenges of small microfluidic volumes is in analysis of proteins and small molecules that are indicative of cellular function. We have developed a panel of biochemical assays that can measure in real-time the secretions from cells cultured in microfluidic devices.
Report abuse