Research Interests

Biomolecular condensates formed by liquid-liquid phase separation of proteins and nucleic acids through multivalent interactions are classified as membraneless organelles. This type of confinement of such large biomolecules in a nanometer-scale environment not only modifies the functional properties of these biomolecules but also creates a heterogeneous phase inside the cells. LLPS formed through the irreversible aggregation of proteins can lead to the onset of neurodegenerative diseases. The dynamic behavior of LLPS depending on the local molecular environment is fundamental to control biological processes. Hence, the development of dynamic biomolecular condensates and understanding the conformational dynamics of biomacromolecules in inducing dynamic LLPS could be vital for drug therapy and targeted cellular imaging.