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Schematic of the Nuclear Pore Subcomplexes and constituent nucleoporins
Research Objective
Research Objective
We broadly aim to answer pertinent questions such as how the nuclear pore complex proteins, known as nucleoporins, contribute to cancer.
Specifically, our goal is to examine the role of Nup88-Nup214 subcomplex and Nup62 overexpression and associated underlying molecular mechanisms in oral cancer progression.
Relevance of Research
Relevance of Research
Successful implementation of this study will provide significant mechanistic insights about the downstream functioning of nucleoporins in cell and how their differential expression (which has now been very commonly observed in several cancers) mediates cancer development for effective therapeutics in future.
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