Publications
14) Location-agnostic site-specific protein bioconjugation via Baylis Hillman adducts. Mudassir H. Mir, Sangeeta Parmar, Chhaya Singh and Dimpy Kalia*. Nature Communications, 2024, 15, 859.
13) Michael addition-elimination-cyclization based turn-on fluorescence (MADELCY TOF) probes for cellular cysteine imaging and estimation of blood serum cysteine and aminoacylase-1. Dastgir Shakil Shaikh, Sangeeta Parmar and Dimpy Kalia*. Analyst, 2022,147, 3876–3884.
12) Aldehyde-mediated bioconjugation via in-situ generated ylides. Sangeeta Parmar, Sharad P. Pawar, Ramkumar Iyer and Dimpy Kalia*. Chem. Commun., 2019, 55, 14926-14929.
11) Stable and rapid thiol bioconjugation via light-triggered thio-maleimide ring hydrolysis. Dimpy Kalia*, Sharad P. Pawar and Jyoti S. Thopate. Angew. Chem. Int. Ed. Engl., 2017, 56, 1885–1889.
10) Exocyclic olefinic maleimides: Synthesis and application for stable thiol-selective bioconjugation. Dimpy Kalia*, Pushpa V. Malekar and Manikandan Parthasarathy. Angew. Chem. Int. Ed. Engl., 2016, 55, 1432–1435. VIP (Very Important Paper).
9) U.S. Patent: Rufinamide and derivatives and their use in modulating the gating process of human voltage-gated sodium channels. Frank Bosmans and Dimpy Kalia. U.S. Patent No. 9505727. Granted: November 29, 2016, Filed: July 31, 2015.
8) Synthesis and anti-tubercular activity of conformationally-constrained and bisquinoline analogs of TMC207. Dimpy Kalia*, Anil Kumar K.S., Gajanand Meena, Kashmir Prasad Sethi, Rohit Sharma, Priyanka Trivedi, Shaheb Raj Khan, Ajay Singh Verma, Shyam Singh, Sandeep Sharma, Kuldeep K Roy, Ruchir Kant, Manju Yasodha Krishnana, Bhupendra N. Singh, Sudhir Sinha, Vinita Chaturvedi*, Anil K Saxena and Dinesh K Dikshit*. MedChemComm, 2015, 6, 1554–1563.
7) Synthetic Quorum Sensing Inhibitors: Signal Analogues. Dimpy Kalia*. Book chapter in book entitled "Quorum Sensing vs Quorum Quenching: A battle with no end in sight." 2015, Springer, Dr. V. C. Kalia (Editor).
From postdoctoral and Ph.D. work
6) Diminazene or berenil, a classic duplex minor groove binder, binds to G-quadruplexes with low nanomolar dissociation constants and the amidine groups are also critical for G-quadruplex binding. Jie Zhou, Vu Le, Dimpy Kalia, Shizuka Nakayama, Clinton Mikek, Edwin A. Lewis and Herman O. Sintim. Mol. Biosyst., 2014, 10, 2724–2734.
5) N–O tethered carbenoid cyclopropanation facilitates the synthesis of a functionalized cyclopropyl-fused pyrrolidine. Dimpy Kalia, Gokce Merey, Min Guo and Herman O. Sintim. J. Org. Chem., 2013, 78, 6131–6142.
4) Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp, signaling in bacteria and implications in pathogenesis. Dimpy Kalia, Gokce Merey, Shizuka Nakayama, Yue Zheng, Jie Zhou, Yiling Luo, Min Guo, Benjamin T. Roembke, and Herman O. Sintim, Chem. Soc. Rev., 2013, 42, 305–341.
3) Aza variant of intramolecular nucleophile-catalyzed aldol lactonization (NCAL): formal synthesis of (3S,4R) and (3R,4S) 4-(hydroxymethyl)pyrrolidin-3-ol. Dimpy Sikriwal and Dinesh K. Dikshit, Tetrahedron, 2011, 67, 210–215.
2) A short formal synthesis of three epimers of Penmacric acid. Dimpy Sikriwal, Ruchir Kant, Prakas R. Maulik, and Dinesh K. Dikshit, Tetrahedron, 2010, 66, 6167–6173.
1) Synthesis and in vitro anti-tubercular activity of analogues of R207910/TMC207. Dimpy Sikriwal and Dinesh K. Diskhit, Med. Chem. Res., 2010, 19, S64-S65.