Photosynthetic eukaryotes are among the most ancient and diverse organisms on the planet. They resulted from rounds of endosymbiotic events and have evolved to adapt to a wide range of environments. We focus on the detailed knowledge of the bionenergetic complexes structures from single components as well as their interaction into higher order associates, e.g. supercomplexes, to further understand the mechanisms behind the energetic metabolism.
Goal: The bioenergetics processes cannot be fully understood without a detailed knowledge of the structure and function of its single components as well as their interaction into higher order associates, like supercomplexes, where proper supramolecular organization is crucial to maintain high efficiency of the transfer processes. To further understand the mechanisms behind the energetic metabolism interactions in photosynthetic eukaryotes, a close characterization of the bionenergetic complexes is necessary. Our group is interested in the interconnection of Basic Science with Biomedicine and Biotechnology through several crossed-projects as schemed here:
Biochemical, functional and structural characterization of the Oxidative Phosphorylation machinery from several eukaryotic species
Biochemical, functional and structural characterization of the photosynthetic machinery from several photosynthetic species
Consequence of eukaryotic diversity on structure/function of conserved membrane megacomplexes
Design of target-specific culture systems and optimization of biomolecules production
Design of specie-specific antiparasitic drugs
Contact Dr. Héctor Vicente Miranda Astudillo (hmiranda@iibiomedicas.unam.mx) to get more information about the project.