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Bhaskar successfully defended his PhD viva with remarkable confidence and scholarly insight. His rigorous approach to research and thoughtful articulation of ideas reflected years of dedication and hard work. This achievement is a testament to his perseverance and academic excellence. We are incredibly proud of him and excited to see the impact he will continue to make in the world of research. 🌟🎓
Congratulations, Dr. Bhaskar Saikia !
Our new paper is available on medRxiv
Mukesh Kumar, Treesa Issen, Mohammed Swalih, Srishti Sharma, Sheffali Gulati, Sridhar Sivasubbu, Vinod Scaria, BK Binukumar. Genetic Spectrum of Autism Spectrum Disorder Associated Variants in the Indian Population: Insights from 1,029 IndiGenomes
medRxiv 2025.08.14.25333641; doi: https://doi.org/10.1101/2025.08.14.25333641
Sangita Paul, Juhi Bhardwaj, Srishti Sharma,MohammedSwalih,Deepanshi Koul, B.K. Binukumar. Heterozygous Lepr Mutation Accelerates Alzheimer-like Neurodegeneration in db/+ Mice via CDK5 Hyperactivation.
bioRxiv 2025.08.28.672812; doi: https://doi.org/10.1101/2025.08.28.672812.
BK Lab took over IAN 2025, making waves from talks to posters!
Binu delivered a talk titled “Decoding Genomes: Unlocking Pathways to Precision Medicine” at the Three-Day National Seminar on Recent Advances in Molecular Biology (RAMB 2025), held from 15–17 October 2025 at Kannur University, Kerala.
Binu delivered a talk titled “Genetic Testing in Clinical Practice: How, What and Why?” in the workshop Demystifying Cytomolecular Genetics for Pediatric Neurologists during the 17th Asian Oceanian Congress of Child Neurology (AOCCN 2025), held on 16 September 2025 at the All India Institute of Medical Sciences (AIIMS), New Delhi.
Srishti Sharma attended the Human Genome Meeting 2025 (HGM) in Durban, South Africa, where she presented her research in an oral presentation. The conference brought together researchers worldwide to discuss advancements in genomics and human health.
 Our paper, titled “A Cdk5 Inhibitor Restores Cognitive Function and Alleviates Type 2 Diabetes in Mice,” has been accepted for publication in iScience.Â
Sangita brilliantly defended her PhD viva. Her passion for research and in-depth knowledge left everyone inspired. We are immensely proud of her achievements and can’t wait to see her soar to even greater heights in her academic journey! 🌟🎓👏 Congratulations, Dr. Sangita!Â
 Our Paper on “Cdk5-mediated oligodendrocyte myelin breakdown and neuroinflammation: Implications for the link between Type 2 Diabetes and Alzheimer's disease”was accepted for publication in Biochim Biophys Acta Mol Basis Dis.
Listen to Sangita Paul talk about her work - Story of phosphorylation and inflammation in PD, in this video: www.youtube.com/watch?v=2oPqDo0YXgQ .Â
Our paper on ATP7A Clinical Genetics Resource - a comprehensive clinically annotated database and resource for genetic variants in ATP7A gene. was accepted for publication in Computational and Structural Biotechnology Journal (CSBJ)
Our new ATP7A Clinical Genetics Resource- http://clingen.igib.res.in/ATP7Agen
Our perspective article “The Indian Collaborative Research on Wilson’s Disease - an effort to understand the genetic epidemiology of Wilson's Disease in India”. Binukumar BK, ICROWD Consortium.
Translational Genomics Vol. 1 No. 1 (2020): Issue 1
https://companyofscientists.com/index.php/tg/article/view/171Â
Our new blog- Wilson’s Disease - from Genomics to Genome Editing  https://genomeconnect.blogspot.com/2020/07/wilsons-disease-from-genomics-to-genome.html
Our paper on “WilsonGen a comprehensive clinically annotated genomic variant resource for Wilson’s Disease” was accepted for publication in Scientific Reports.
Our new Wilson’s Disease KB http://clingen.igib.res.in/WilsonGen/
Srishti Sharma joins the lab as a PhD student. Welcome aboard, Srishti !!!
Our new collaborative paper entitled “Overexpression of the Cdk5 inhibitory peptide in motor neurons rescue of amyotrophic lateral sclerosis phenotype in a mouse model” is accepted for publication in Human Molecular Genetics.
We established a new in-house resource, the Neurobehavioral lab. To study rodent responses to internal and external stimuli, with the goal of gaining insight into nervous system function and dysfunction associated with neurological and psychiatric disorders. Behavioral assays: Morris Water Maze, Elevated Plus Maze, Y-Maze , T-Maze, Barnes- Maze, Zero- Maze, Open Field, Light/Dark Box, Object Recognition Memory Task, Rotarod Apparatus, Grip Strength Meter, Fear Conditioning, Tail Suspension test unit
Sandhy Sathyan submitted her M.Sc dissertation (April 2019)
Topic Editor. Online launch of Research Topic "Mitochondrial Dysfunction, Mitophagy & Autophagy in Alzheimer's Disease" (ID: 9344) in Frontiers in Aging Neuroscience.  https://www.frontiersin.org/research-topics/9344/mitochondrial-dysfunction-mitophagy-autophagy-in-alzheimers-disease
Our new review on “Crosstalk Between the Unfolded Protein Response, MicroRNAs, and Insulin Signaling Pathways: In Search of Biomarkers for the Diagnosis and Treatment of Type 2 Diabetes is out!
Payel Das submitted her M.Sc dissertation (June 2018)
We received DST-SERB early career award! (May 2017)
Our new paper is available on Bioarchive
CDK5 mediated phosphorylation of cytosolic phospholipase A2 regulates its activity and neuroinflammation in Parkinson's Disease
Sangita Paul, Saman Fatihi, Srishti Sharma, Rintu Kutum, Raymond Fields, Harish C Pant, Lipi Thukral, Binukumar BK
doi: https://doi.org/10.1101/2021.11.05.467380
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