Journal Publications

  1. Waite, J., Tana, S., Saha, H., Sarkar, S., Sarkar, A. (2022). Few-shot Deep Learning for AFM Force Curve Characterization of Single Molecule Interactions. Accepted in Patterns

  2. Rade, J., Zhang, J., Sarkar, S., Krishnamurthy, A., Ren, J., & Sarkar, A. (2022). Deep Learning for Live Cell Shape Detection and Automated AFM Navigation. Bioengineering, 9(10), 522.

  3. Sarkar, A. (December 2021). Biosensing, characterization of biosensors, and improved drug delivery approaches using Atomic Force Microscopy: A review. Frontiers in Nanotechnology

  4. Sarkar, A*., Mao, S.*, Wang, Y., Song, C., LeVine, D., Wang, X., and Que, L. (2021). Microfluidic chip grafted with integrin tension sensors for evaluating the effects of flowing shear force and ROCK inhibitor on platelets. Lab on a chip, (* made equal contribution and they share the first authorship)

  5. Sarkar, A., LeVine, D. N., Kuzmina, N., Zhao, Y., & Wang, X. (2020). Cell migration driven by self-generated integrin ligand gradient on ligand-labile surfaces. Current Biology, 30(20), 4022-4032. doi: https://doi.org/10.1016/j.cub.2020.08.020

  6. Sarkar, A., LeVine, D., Zhao, Y., Mollaeian, K., Ren, J., & Wang, X. (2020). Tandem tension sensor reveals substrate rigidity-dependence of integrin molecular tensions in live cells. bioRxiv. doi: https://doi.org/10.1101/2020.01.24.918946

  7. Zhao, Y., Sarkar, A., & Wang, X. (2020). Peptide nucleic acid based tension sensor for cellular force imaging with strong DNase resistance. Biosensors and Bioelectronics, 150, 111959. doi: https://doi.org/10.1016/j.bios.2019.111959

  8. Wang, Y., Zhao, Y., Sarkar, A., & Wang, X. (2019). Optical sensor revealed abnormal nuclease spatial activity on cancer cell membrane. Journal of biophotonics, 12(5), e201800351. DOI: 10.1002/jbio.201800351

  9. Sarkar, A., Zhao, Y., Wang, Y., & Wang, X. (2018). Force-activatable coating enables high-resolution cellular force imaging directly on regular cell culture surfaces. Physical biology, 15(6), 065002. doi: 10.1088/1478-3975/aac69d

  10. Wang, Y., LeVine, D. N., Gannon, M., Zhao, Y., Sarkar, A., Hoch, B., & Wang, X. (2018). Force-activatable biosensor enables single platelet force mapping directly by fluorescence imaging. Biosensors and Bioelectronics, 100, 192-200. DOI: 10.1016/j.bios.2017.09.007

  11. Zhao, Y., Wang, Y., Sarkar, A., & Wang, X. (2018). Keratocytes generate high integrin tension at the trailing edge to mediate rear De-adhesion during rapid cell migration. Iscience, 9, 502-512. doi: https://doi.org/10.1016/j.isci.2018.11.016

  12. Sarkar, A.#, Sohail, A., Dong, J., Prunotto, M., Shinki, K., Fridman, R., & Hoffmann, P. M. (2019). Live cell measurements of interaction forces and binding kinetics between Discoidin Domain Receptor 1 (DDR1) and collagen I with atomic force microscopy. Biochimica et Biophysica Acta (BBA)-General Subjects, 1863(11), 129402. DOI: 10.1016/j.bbagen.2019.07.011

  13. Jones, S. K., Sarkar, A.#, Feldmann, D. P., Hoffmann, P., & Merkel, O. M. (2017). Revisiting the value of competition assays in folate receptor-mediated drug delivery. Biomaterials, 138, 35-45. doi: https://doi.org/10.1016/j.biomaterials.2017.05.034



Conference Publications

  1. J. Rade, S. Sarkar, A. Krishnamurthy, A. Sarkar, Virtual AFM: Generating Synthetic 2D Multi-view Images from 3D Protein Structure, Biomedical Engineering Society (BMES) Annual meeting, San Antonio, TX, 2022.

  2. A. Koep, A. Sarkar, S. Alam, T. Prozorov, I. Schneider, Actuatable Hollow DNA Origami Drug Delivery Constructs, Biomedical Engineering Society (BMES) Annual meeting, San Antonio, TX, 2022.

  3. J. Rade, S. Sarkar, A. Sarkar, A. Krishnamurthy, 3D Reconstruction of Protein Complex Structures Using Synthesized Multi-View AFM Images, Machine Learning in Structural Biology (MLSB) Workshop at the 36th Conference on Neural Information Processing Systems (NeurIPS), New Orleans, LA, 2022.

  4. A. Sarkar, N. Hassan, R. Bardhan, Multimodal characterization of live cancer cells using Atomic Force Microscopy and Raman spectroscopy, presented as a poster, Biophysical Society 66th Annual Meeting, San Francisco, CA 2022.

  5. A. Sarkar, S. Yang, B. Chen, High Resolution Single Molecule Imaging of WRC-Rac1 Protein Complex with Atomic Force Microscopy, Biomedical Engineering Society (BMES) Annual meeting, Orlando, Fl 2021.

  6. J. Rade, S. Sarkar, A. Krishnamurthy, J. Ren, A. Sarkar, AI Guided Measurement of Live Cells Using AFM, Modelling, Estimation and Control Conference (MECC), Austin, TX 2021.

  7. A. Sarkar, J. Waite, S. Sarkar, Deep learning for fast Atomic Force Microscopy data analytics, selected for platform presentation and presented as a talk, Biophysical Society 65th Annual Meeting (virtual) 2021.

  8. S. Mao~ , A. Sarkar ~, D. LeVine, X. Wang, L. Que, Studies of the drug treatment effects on platelets using integrative tension sensors embedded in a microfuidic chip, Microfluidics for Hematology, presented as talk, Chicago, IL 2020 (~ made equal contribution and share the first authorship)

  9. A. Sarkar, Y. Wang, X. Wang, Determining Integrin Molecular Tension for the Recruitment and the activation of Focal Adhesion Kinase, Biophysical Society (BPS), 63rd Annual meeting, presented as poster, Baltimore, MD 2019.

  10. A. Sarkar, X. Wang, Integrin molecular tensions in live cells are altered by substrate rigidity, Biophysical Society (BPS), 62nd Annual meeting, presented as a talk and poster, San Francisco, CA 2018 [the work was also presented as a talk and poster in the ISU Research Day, Iowa State University, 2018]

  11. A. Sarkar, R. Fridman, A. Sohail and P. M. Hoffmann, Measurement of DDR-Collagen interaction Forces with Atomic force Microscopy, American Physical Society (APS) March Meeting, San Antonio, TX 2015

  12. A. Sarkar, E. Mayyas and P. M. Hofmann, Effect of Surface Density of Active sites on Rupture Force Distributions of Single Molecule Interactions, Biophysical Society (BPS), 59th Annual Meeting, Baltimore, MD 2015

  13. A. Sarkar and P. M. Hoffmann, Effect of active site density on rupture force distributions in ligand-protein force measurements, American Physical Society (APS) Ohio-Region Section Meeting, April 2014, Youngstown, OH (presented as poster) [the work was also presented during the Physics Graduate Research Day, Wayne State University, April 2014]

  14. A. Sarkar, E. Kramkowski, E. Mayyas and P. M. Hoffmann, Multiple attachments, heterogeneous binding and the high force tail in protein-protein binding force histograms, American Physical Society (APS) March Meeting, March 2013, Baltimore, MD (presented as poster) [the work was also presented during the Physics Graduate Research Day, Wayne State University, April 2013]

  15. A. Sarkar, E. Kramkowski and P. M. Hoffmann, Live cell imaging and determination of protein-protein rupture force with AFM, American Physical Society (APS) Ohio-Region Section Meeting, October 2012, Detroit, MI (presented as poster) [the work was also presented in Michigan Microscopy and Microanalysis Society Fall 2012 Meeting]


Invited Talks

  1. A. Sarkar, Single molecule interaction forces and reaction kinetics of ligand-receptor systems using AFM on live cells and fast data analytics, Biomedical Engineering Society at Iowa State University, November 2022.

  2. A. Sarkar, Force activatable biosensors and fast Atomic Force Microscopy data analytics using machine learning approaches, Department of Physics, Wayne State University, March 2022.

  3. A. Sarkar, High resolution imaging, nanomechanical characterization, and measurement of interaction forces and binding kinetics of protein-protein interactions with AFM, Nanovaccine Institute, Iowa State University, December 2021 (2021 Fall Seminars).

  4. A. Sarkar, S. Yang and B. Chen, High Resolution Single Molecule Imaging of WRC-Rac1 Protein Complex with Atomic Force Microscopy, 2021 Biomedical Engineering Society (BMES) Annual meeting, October 2021, Orlando, FL.

  5. A. Sarkar, Measurement of interaction forces and binding kinetics of protein-protein interactions with AFM, Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, March 2021 (2021 Spring Seminars).

  6. A. Sarkar, J. Waite, S. Sarkar, Deep learning for fast Atomic Force Microscopy data analytics, selected for platform presentation and presented as a talk, Biophysical Society 65th Annual Meeting (virtual) 2021.

  7. A. Sarkar, Single molecule force measurements on live cells with Atomic Force Microscopy (AFM) and force activatable biosensors at Department of Electrical and Computer Engineering, Iowa State University, March 2020.

  8. A. Sarkar, X. Wang, Integrin molecular tensions in live cells are altered by substrate rigidity, Biophysical Society (BPS), 62nd Annual meeting, presented as a talk, San Francisco, CA, 2018.

  9. A. Sarkar, Interaction forces and reaction kinetics of ligand-cell receptor systems using Atomic Force Microscopy (AFM) at Department of Physics, Iowa State University, October 2015.