Publications (101)

• Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome

  • • Oct 2014

    • Judy Mikovits  /   Vincent C Lombardi  /   Max A Pfost  /   Kathryn S Hagen  /   Francis Ruscetti

    • In October 2009, we reported the first direct isolation of infectious xenotropic murine leukemia virus-related virus (XMRV). In that study, we used a combination of biological amplification and molecular enhancement techniques to detect XMRV in more than 75% of 101 patients with chronic fatigue syndrome (CFS). Since our report, controversy arose af...

• Innate immune changes in the peripheral blood of chronic fatigue syndrome patients: Risk factors for disease progression and management

  • • Jan 2014

    • D.L.S. Goetz  /   Judy Mikovits  /   Jamie Deckoff-Jones  /   Francis Ruscetti

    • Chronic Fatigue Syndrome (CFS) is recognized by the WHO as an alternative name for Myalgic Encephalomyelitis, which has been classified as a disease of the central nervous system since 1969. The concept that chronic microbial infection drives constant activation of the innate immune system through alterations in the production of innate immune cell...

• Clonal T-cells and monocytosis in cancer patients and relationship to prognosis, and incidence of autoimmunity, fatigue, and second primary malignancies.

  • • May 2013

    • Michael Snyderman   /   Judy Mikovits

    • e22038 Background: Clonal T-cell expansion and monocytosis could explain inflammation, fatigue and autoimmunity seen with cancer if both cell types release excess amounts of cytokines and disregulate the immune system. Cytokines can also have a paracrine effect and increase malignant cell proliferation. Methods: 48 patients with various neoplasms f...

• Anti-retroviral drugs used to treat a patient with chronic lymphocytic leukemia and cancer-related fatigue.

  • • May 2013

    • Judy Mikovits   /   Michael Snyderman

    • e22039 Background: The only known human cancer retrovirus, HTLV1 causes adult T-cell leukemia/lymphoma of which some respond to AZT+ alpha interferon. The existence of human retroviruses originating from murine leukemia viruses (MLVs) and their role in human cancer has been debated since the 1970s. A previously untreated 68 y.o. Oncologist with B-c...

• A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus

  • • Sep 2012

    • Harvey J. Alter   /   Judy Mikovits   /   William M Switzer   /   Francis Ruscetti   /   Shyh-Ching Lo   /   Nancy G Klimas   /   Anthony L Komaroff   /   Jose Gilberto Montoya   /   Lucinda Bateman   /   Susan Levine   /   Daniel Peterson   /   Bruce Levin   /   Maureen R Hanson   /   Afia Genfi   /   Muhsin Bhat   /   Haoqiang Zheng   /   Richard Yuan-Hu Wang   /   Bingjie Li   /   Guo-Chiuan Hung   /   Li Ling Lee   /   Stephen Sameroff   /   Walid Heneine   /   John Coffin   /   Mady Hornig  /   W. Ian Lipkin

    • IMPORTANCE Chronic fatigue syndrome/myalgic encephalomyelitis has an estimated prevalence of 42/10,000 in the United States, with annual direct medical costs of $7 billion. Here, the original investigators who found XMRV and pMLV (polytropic murine leukemia virus) in blood of subjects with this disorder report that this association is not confirmed...

• Partial retraction. Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome

  • • Oct 2011

    • Robert H Silverman   /   Jaydip Das Gupta   /   Vincent C Lombardi   /   Francis Ruscetti   /   Max A Pfost   /   Kathryn S Hagen   /   Daniel L Peterson   /   Sandra K Ruscetti   /   Rachel K Bagni   /   Cari Sadowski   /   Bert Gold   /   Michael Dean   /   Judy Mikovits

• Partial Retraction

• Article

  • Sep 2011

  • Robert H Silverman

  • Jaydip Das Gupta

  • Vincent C Lombardi

  • [...]

  • Judy Mikovits

• In our 23 October 2009 Report, "Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome" (1), two of the coauthors, Silverman and Das Gupta, analyzed DNA samples from chronic fatigue syndrome (CFS) patients and healthy controls. A reexamination by Silverman and Das Gupta of the samples they used shows t...

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• Failure to Confirm XMRV/MLVs in the Blood of Patients with Chronic Fatigue Syndrome: A Multi-laboratory Study

• Article

• Full-text available

  • Sep 2011

  • Graham Simmons

  • Simone Glynn

  • Anthony L Komaroff

  • [...]

  • Michael P Busch

• Murine leukemia viruses (MLVs), including xenotropic-MLV-related virus (XMRV), have been controversially linked to chronic fatigue syndrome (CFS). To explore this issue in greater depth, we compiled coded replicate samples of blood from 15 subjects previously reported to be XMRV/MLV-positive (14 with CFS) and from 15 healthy donors previously deter...

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• Myalgic Encephalomyelitis: International Consensus Criteria

• Article

• Full-text available

  • Jul 2011

  • B.M. Carruthers

  • M.I. van de Sande

  • K.L. de Meirleir

  • [...]

  • Staci R Stevens

• The label 'chronic fatigue syndrome' (CFS) has persisted for many years because of the lack of knowledge of the aetiological agents and the disease process. In view of more recent research and clinical experience that strongly point to widespread inflammation and multisystemic neuropathology, it is more appropriate and correct to use the term 'myal...

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• Development of XMRV producing B Cell lines from lymphomas from patients with Chronic Fatigue Syndrome

• Article

• Full-text available

  • Jun 2011

  • Francis Ruscetti

  • Vincent C Lombardi

  • Michael Snyderman

  • [...]

  • Judy Mikovits

• Previous studies have shown that CFS patients have an increased incidence of lympho-proliferative malignancy compared to the normal population [1]. While the incidence rate of non-Hodgkin’s lymphoma in the United States is 0.02%, nearly 5% of the CFS patients developed the disease. Additionally, development of cancer coincides with an outgrowth of...

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• Immune correlates of XMRV infection

• Article

• Full-text available

  • Jun 2011

  • Vincent C Lombardi

  • Deborah Goetz

  • Max Pfost

  • [...]

  • Judy Mikovits

• Methods This hypothesis was addressed by multiplex profiling of plasma cytokines and chemokines on a LuminexTM platform and phenotypic analysis of leukocyte subsets by multi-parameter flow cytometry in XMRV infected CFS patients versus uninfected controls. XMRV-infected subject and control samples were assayed blindly. Analysis was performed using...

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• Multi-laboratory evaluations of XMRV nucleic acid detection assays

• Article

• Full-text available

  • Jun 2011

  • Graham Simmons

  • John Coffin

  • Indira K Hewlett

  • [...]

  • Michael P Busch

• The Blood XMRV Scientific Research Working Group was formed to facilitate collaborative studies into the impact of XMRV in blood donors. Studies will evaluate XMRV detection assays in terms of sensitivity, specifi-city and reproducibility; assess performance on specimens represented in existing blood donor repositories, and determine the prevalence...

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• 109 XMRV: Virological, Immunological and Clinical Correlations in a Patient with Chronic Lymphocytic Leukemia

• Article

  • Jun 2011

  • Michael Snyderman

  • Isabel Silvester-Barao

  • Deborah Goetz

  • [...]

  • Judy Mikovits

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• Xenotropic murine leukemia virus-related virus-associated chronic fatigue syndrome reveals a distinct inflammatory signature

• Article

• Full-text available

  • May 2011

  • Vincent C Lombardi

  • Kathryn S Hagen

  • Kenneth W Hunter

  • [...]

  • Judy Mikovits

• The recent identification of xenotropic murine leukemia virus-related virus (XMRV) in the blood of patients with chronic fatigue syndrome (CFS) establishes that a retrovirus may play a role in the pathology in this disease. Knowledge of the immune response might lead to a better understanding of the role XMRV plays in this syndrome. Our objective w...

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• The Blood Xenotropic Murine Leukemia Virus-Related Virus Scientific Research Working Group: Mission, progress, and plans

• Article

  • Mar 2011

  • Graham Simmons

  • Simone Glynn

  • Jerry Holmberg

  • [...]

  • Michael P Busch

• Recently, there have been studies that indicate that Xenotropic Murine Leukemia Virus (MLV)-related Virus (XMRV), a newly described human gammaretrovirus, and other related viruses, may be associated with both prostate cancer and myalgic encephalomyelitis (ME) / chronic fatigue syndrome (CFS)1–4. It has also been suggested that these viruses have t...

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• Possible Genetic Dysregulation in Pediatric CFS

• Article

• Full-text available

  • Jul 2010

  • Leonard A Jason

  • Matthew Sorenson

  • Nicole Porter

  • [...]

  • Judy Mikovits

• Hypocortisolism is a frequent finding in individuals with chronic fatigue syndrome (CFS) and could play an explana-tory role in the development of illness symptomatology. The etiologic mechanism behind this finding could be genetic variance in glucocorticoid receptor expression (GR) or increased resistance to the effects of glucocorticoids. Several...

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• Xenotropic murine leukemia virus-related virus: Current research, disease associations and therapeutic opportunities

• Article

  • Jul 2010

  • Judy Mikovits

  • Vincent C Lombardi

  • Francis Ruscetti

• Despite the fact that xenotropic murine leukemia virus-related virus (XMRV) research is in its infancy, considerable attention has been focused on this recently discovered human retrovirus because of the surprising association of XMRV with two very different diseases: prostate cancer and myalgic encephalomyelitis/chronic fatigue syndrome. Like othe...

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• Distribution of Xenotropic Murine Leukemia Virus-Related Virus (XMRV) Infection in Chronic Fatigue Syndrome and Prostate Cancer

• Article

  • Jul 2010

  • Judy Mikovits

  • Ying Huang

  • Max A Pfost

  • [...]

  • Francis Ruscetti

• In 2006, sequences described as xenotropic murine leukemia virus-related virus (XMRV) were discovered in prostate cancer patients. In October 2009, we published the first direct isolation of infectious XMRV from humans and the detection of infectious XMRV in patients with chronic fatigue syndrome. In that study, a combination of classic retroviral...

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• Response to Comments on “Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome”

• Article

  • May 2010

  • Judy Mikovits

  • Francis Ruscetti

• We reported the detection of the human gammaretrovirus XMRV in 67% of 101 patients with chronic fatigue syndrome (CFS) and in 3.7% of 218 healthy controls, but we did not claim that XMRV causes CFS. Here, we explain why the criticisms of Sudlow et al., Lloyd et al., and van der Meer et al. regarding the selection of patients and controls in our stu...

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• Inactivation of XMRV in platelet and RBC components prepared with the INTERCEPT blood system [abstract]

• Article

  • Jan 2010

  • Judy Mikovits

  • Kathryn Hagen

  • Weiqun Liu

  • [...]

  • Lily Lin

• 
  

• Detection and Immune Correlates of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome

• Article

  • Oct 2009

  • Judy Mikovits

  • NOTE - THIS IS A GUEST SPEAKER OPPORTUNITY  ( https://sci-hub.se/10.1016/j.cyto.2009.07.043 ) 

• 
  

• Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome

• Article

• Full-text available

  • Oct 2009

  • Vincent C Lombardi

  • Francis Ruscetti

  • Jaydip Das Gupta

  • [...]

  • Judy Mikovits

• Chronic fatigue syndrome (CFS) is a debilitating disease of unknown etiology that is estimated to affect 17 million people worldwide. Studying peripheral blood mononuclear cells (PBMCs) from CFS patients, we identified DNA from a human gammaretrovirus, xenotropic murine leukemia virus–related virus (XMRV), in 68 of 101 patients (67%) as compared to...

• LINK ... THIS WAS RETRACTED . .https://sci-hub.se/10.1126/science.1179052  

• Please see: Partial Retraction - 14 October 2011

• This article has been retracted.

• Please see: Retraction - 23 December 2011

• 
  

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• Xenotropic MuLV-related virus clone WPI-1104 putative gag polyprotein (gag) and putative envelope glycoprotein (env) genes, partial cds

• Data

  • Aug 2009

  • J. Gupta

  • R.H. Silverman

  • Judy Mikovits

  • Vincent C Lombardi

• View

• Xenotropic MuLV-related virus clone WPI-1178 putative gag-pro-pol polyprotein (gag-pro-pol), putative gag polyprotein (gag), and putative envelope glycoprotein (env) genes, complete cds

• Data

  • Aug 2009

  • J. Gupta

  • R.H. Silverman

  • Judy Mikovits

  • Vincent C Lombardi

• View

• Xenotropic MuLV-related virus clone WPI-1106 putative gag-pro-pol polyprotein (gag-pro-pol), putative gag polyprotein (gag), and putative envelope glycoprotein (env) genes, complete cds

• Data

  • Aug 2009

  • J. Gupta

  • R.H. Silverman

  • Judy Mikovits

  • Vincent C Lombardi

• View

• ABERRANT EXPRESSION OF LYMPHOCYTE CYTOTOXIC PROTEINS IN CHRONIC FATIGUE SYNDROME

• Conference Paper

  • Nov 2008

  • David Tamang

  • Vinnie Lombardi

  • Dan Peterson

  • [...]

  • Doug Redelman

• View

• 36 Serum cytokine and chemokine profiles of individuals with myalgic encephalomyelitis (ME) reveal distinct pathogen associated signatures

• Article

  • Sep 2008

  • Doug Redelman

  • Darren C. White

  • Marc Fremont

  • [...]

  • Judy Mikovits

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• Reactivation of Kaposi's sarcoma-associated herpesvirus by natural products from Kaposi's sarcoma endemic regions

• Article

  • Jan 2007

  • Denise Whitby

  • Vickie A Marshall

  • Rachel K Bagni

  • [...]

  • David J Newman

• Kaposi's sarcoma (KS) and its causative agent, Kaposi's sarcoma associated herpesvirus (KSHV/HHV-8), a gamma2 herpesvirus, have distinctive geographical distributions that are largely unexplained. We propose the "oncoweed" hypothesis to explain these differences, namely that environmental cofactors present in KS endemic regions cause frequent react...

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• Regulation of hMSH2 and hMLH1 expression in the human colon cancer cell line SW1116 by DNA methyltransferase 1

• Article

  • Feb 2006

  • Jing Yuan Fang

  • Rong Lu

  • Judy Mikovits

  • [...]

  • Ying Xuan Chen

• Aberrant DNA methylation is now recognized as an important epigenetic alteration occurring early in human cancer. To directly study the role of DNA methyltransferase 1 (DNMT1) in the regulation of expression of tumor-related genes in human colon cancer cells, we stably transfected expression constructs containing sense or antisense DNMT1 into the h...

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• Epigenetic Control during Lymphoid Development and Immune Responses

• Article

  • Jan 2006

  • KATHRIN MUEGGE

  • Howard A Young

  • Francis Ruscetti

  • Judy Mikovits

• Methylation of cytosines controls a number of biologic processes such as imprinting and X chromosomal inactivation. DNA hypermethylation is closely associated with transcriptional silencing, while DNA hypomethylation is associated with transcriptional activation. Hypoacetylation of histones leads to compact chromatin with reduced accessibility to t...

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• Alterations in mast cell function and survival following in vitro infection with human immunodeficiency viruses-1 through CXCR4

• Article

  • Sep 2004

  • Daniel Dennis Taub

  • Judy Mikovits

  • Gunnar Nilsson

  • [...]

  • Francis Ruscetti

• HIV-1 infection leads to a disease that attacks the central regulatory mechanisms of the immune response. As mucosal tissue is one of the primary sites infected with HIV in vivo, we examined the effects of HIV exposure on human mast cells, important components of mucosal defense. Using the human mast cell line, HMC-1, which expresses CXCR4 but not...

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• An inhibitor of glycosphingolipid metabolism blocks HIV-1 infection of primary T-cells

• Article

  • May 2004

  • Anu Puri

  • Satinder Singh Rawat

  • Han-Ming Joseph Lin

  • [...]

  • Robert Blumenthal

• HIV-1 uses CD4 and chemokine receptors to enter cells. However, other target membrane components may also be involved. This study examines the role of glycosphingolipids (GSL) in HIV-1 entry into primary lymphocytes and its modulation by an inhibitor of GSL biosynthesis. CD4 lymphocytes purified from normal or the p-group subtype individuals that w...

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• Expression and purification of recombinant Kaposi's sarcoma-associated herpesvirus DNA polymerase using a Baculovirus vector system

• Article

  • Jun 2003

  • Dorjbal Dorjsuren

  • Yunden Badralmaa

  • Judy Mikovits

  • [...]

  • Shizuko Sei

• The DNA polymerase (POL) of Kaposi's sarcoma-associated herpesvirus (KSHV) is essential for viral DNA replication and, thus, may be considered as a viable target for anti-KSHV therapeutics. To produce large quantities of homogeneous and pure POL required for high-throughput screening (HTS) for inhibitors, we generated a recombinant baculovirus vect...

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• Epigenetic control during lymphoid development and immune responses: Aberrant regulation, viruses, and cancer

• Article

  • Apr 2003

  • Kathrin Muegge

  • Howard A Young

  • Francis Ruscetti

  • Judy Mikovits

• Methylation of cytosines controls a number of biologic processes such as imprinting and X chromosomal inactivation. DNA hypermethylation is closely associated with transcriptional silencing, while DNA hypomethylation is associated with transcriptional activation. Hypoacetylation of histones leads to compact chromatin with reduced accessibility to t...

• View

• A Potent Cell-active Allosteric Inhibitor of Murine DNA Cytosine C 5 Methyltransferase

• Article

• Full-text available

  • Apr 2003

  • James Flynn

  • Jing-Yuan Fang

  • Judy Mikovits

  • Norbert O Reich

• The major DNA cytosine methyltransferase isoform in mouse erythroleukemia cells, Dnmt1, exhibits potent dead-end inhibition with a single-stranded nucleic acid by binding to an allosteric site on the enzyme. The previously reported substrate inhibition with double-stranded substrates also involves binding to an allosteric site. Thus, both forms of...

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• Identification of HIV-1 nucleocapsid protein: Nucleic acid antagonists with cellular anti-HIV activity

• Article

  • Oct 2002

  • Andrew G Stephen

  • Karen M Worthy

  • Eric M. Towler

  • [...]

  • Robert J Fisher

• The crucial functions of HIV-1 nucleocapsid-p7 protein (NC-p7) at different stages of HIV replication are dependent on its nucleic acid binding properties. In this study, a search has been made to identify antagonists of the interaction between NC-p7 and d(TG)(4). A chemical library of approximately 2000 small molecules (the NCI Diversity Set) was...

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• Eradication of Human Immunodeficiency Virus Type 1–Infected Cells by a Combination of Antimetabolic Cytotoxic Chemotherapy and Antiviral Chemotherapy In Vitro: A Pilot Study

• Article

• Full-text available

  • Oct 2002

  • Quan-en Yang

  • Kun-gui Li

  • Judy Mikovits

• Although highly active antiretroviral therapy against human immunodeficiency virus (HIV) type 1 reduces the mortality of persons with acquired immunodeficiency syndrome, it does not eliminate HIV reservoirs. In this study, which used a 6-thioguanine (6-TG) resistant clone (4C6) of the MT-2 cell line as a model, the combination of 6-TG with both rev...

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• Results histone hyperacetylation and increased expression of the p21WAF1 gene of Hut 78 cells resulted by HIV-1 infection

• Article

  • Sep 2002

  • J. Fang

  • Judy Mikovits

  • Francis Ruscetti

• Objective: DNA methylation and chromatin modification of histone acetylation are two global mechanisms that regulate gene expression. p16INK4A and p21WAF1 are cyclin-dependent kinases inhibitors. Human immunodeficiency virus type 1 (HIV-1) induces up-regulation of DNA methyltransferase (DNMT), hypermethylation and down-regulation of p16INK4A gene i...

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• Synthesis and Biological Properties of Amino Acid Amide Ligand-Based Pyridinioalkanoyl Thioesters as Anti-HIV Agents

• Article

  • May 2002

  • Yongsheng Song

  • Atul Goel

  • Venkatesha Basrur

  • [...]

  • Ettore Appella

• Hyper-mutable retroviruses such as HIV can become rapidly resistant to drugs used to treat infection. Strategies for coping with drug-resistant strains of virus include combination therapies, using viral protease and reverse transcriptase inhibitors. Another approach is the development of antiviral agents that attack mutationally nonpermissive targ...

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• Infection of Lymphoid Cells by Integration-Defective Human Immunodeficiency Virus Type 1 Increases De Novo Methylation

• Article

• Full-text available

  • Oct 2001

  • Jing-Yuan Fang

  • Judy Mikovits

  • Rachel Bagni

  • [...]

  • Francis Ruscetti

• DNA methylation, by regulating the transcription of genes, is a major modifier of the eukaryotic genome. DNA methyltransferases (DNMTs) are responsible for both maintenance and de novo methylation. We have reported that human immunodeficiency virus type 1 (HIV-1) infection increases DNMT1 expression and de novo methylation of genes such as the gamm...

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• Peptide T inhibits HIV-1 infection mediated by the chemokine receptor-5 (CCR5)

• Article

  • Nov 2001

  • Michael Ruff

  • Loyda M Meléndez

  • Quan-en Yang

  • [...]

  • Francis Ruscetti

• Peptide T, which is derived from the V2 region of HIV-1, inhibits replication of R5 and dual-tropic (R5/X4) HIV-1 strains in monocyte-derived macrophages (MDMs), microglia, and primary CD4(+)T cells. Little to no inhibition by peptide T was observed with lab adapted X4 viruses such as IIIB, MN, or NL4-3 propagated in CD4(+) T cells or in the MAGI e...

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• Additional data file 3

• Data

  • Sep 2001

  • Lloyd T Lam

  • Oxana K Pickeral

  • Amy C Peng

  • [...]

  • Louis M Staudt

• Flavopiridol, actinomycin D and DRB

• View

• Additional data file 1

• Data

  • Sep 2001

  • Lloyd T Lam

  • Oxana K Pickeral

  • Amy C Peng

  • [...]

  • Louis M Staudt

• Flavopiridol titration

• View

• Additional data file 2

• Data

  • Sep 2001

  • Lloyd T Lam

  • Oxana K Pickeral

  • Amy C Peng

  • [...]

  • Louis M Staudt

• Cdk inhibitors

• View

• Additional data file 7

• Data

  • Sep 2001

  • Lloyd T Lam

  • Oxana K Pickeral

  • Amy C Peng

  • [...]

  • Louis M Staudt

• Induced genes in OCI -Ly3 cells

• View

• Additional data file 8

• Data

  • Sep 2001

  • Lloyd T Lam

  • Oxana K Pickeral

  • Amy C Peng

  • [...]

  • Louis M Staudt

• Highly induced genes in PBMC

• View

• Additional data file 4

• Data

  • Sep 2001

  • Lloyd T Lam

  • Oxana K Pickeral

  • Amy C Peng

  • [...]

  • Louis M Staudt

• Half-lives of well-measured genes

• View

• Additional data file 5

• Data

  • Sep 2001

  • Lloyd T Lam

  • Oxana K Pickeral

  • Amy C Peng

  • [...]

  • Louis M Staudt

• Proliferation genes

• View

• Additional data file 6

• Data

  • Sep 2001

  • Lloyd T Lam

  • Oxana K Pickeral

  • Amy C Peng

  • [...]

  • Louis M Staudt

• Anti-apoptotic genes

• View

• Additional data file 9

• Data

  • Sep 2001

  • Lloyd T Lam

  • Oxana K Pickeral

  • Amy C Peng

  • [...]

  • Louis M Staudt

• Highly induced chemokines, cytokines and their receptors

• View

• +3

• The synthetic peptide WKYMVm attenuates the function of the chemokine receptors CCR5 and CXCR4 through activation of formyl peptide receptor-like 1

• Article

• Full-text available

  • Jun 2001

  • Bao-Qun Li

  • Michele Kutzler

  • Judy Mikovits

  • [...]

  • Ji Ming Wang

• The G protein-coupled 7 transmembrane (STM) chemoattractant receptors can be inactivated by heterologous desensitization. Earlier work showed that formly peptide receptor-like 1 (FPRL1), an STM receptor with low affinity for the bacterial chemotactic peptide formyl-methionyl-leucyl-phenylalamine (fMLF), is activated by peptide domains derived from...

• View

• STAT5 pathway: Target of anti-CD4 antibody in attenuation of IL-2 receptor signaling

• Article

  • Apr 2001

  • Jens Goebel

  • Kathy Forrest

  • Judy Mikovits

  • [...]

  • Robin P. Lowry

• Anti-CD4 antibodies induce long-term graft survival by incompletely understood mechanisms, and CD4-ligation with HIV gp120-derivatives attenuates interleukin (IL)-2 receptor signaling. We examined the latter in the context of the CD4-modulating antibody 16H5. We performed immunoblots to assess the IL-2-induced phosphorylation of signal transducer a...

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• Potential Cellular Signatures of Viral Infections in Human Hematopoietic Cells

• Article

• Full-text available

  • Feb 2001

  • Judy Mikovits

  • Francis Ruscetti

  • W Zhu

  • [...]

  • R Shoemaker

• Expression profiling of cellular genes was performed using a 10,000 cDNA human gene array in order to identify expression changes following chronic infection of human hematopoietic cells with Kaposi's Sarcoma-associated Virus (KSHV) also known as Human Herpesvirus 8 (HHV8) and Human T cell leukemia virus-1 (HTLV-1). We performed cell-free in vitro...

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• Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol

• Article

• Full-text available

  • Feb 2001

  • Lloyd T Lam

  • Oxana K Pickeral

  • Amy C Peng

  • [...]

  • Louis M Staudt

• Flavopiridol, a flavonoid currently in cancer clinical trials, inhibits cyclin-dependent kinases (CDKs) by competitively blocking their ATP-binding pocket. However, the mechanism of action of flavopiridol as an anti-cancer agent has not been fully elucidated. Using DNA microarrays, we found that flavopiridol inhibited gene expression broadly, in co...

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• Combined cytokine stimulation of human naive CD4+T cells results in IFN-gamma production in absence of hypomethylation of the IFN-gamma gene promoter

• Article

  • Jan 2001

  • Francis Ruscetti

  • Howard A Young

  • Cari Sadowski

  • [...]

  • Judy Mikovits

• View

• Flavonoid Baicalin Inhibits HIV-1 Infection at the Level of Viral Entry

• Article

  • Oct 2000

  • Bao Qun Li

  • Tao Fu

  • Yao Dongyan

  • [...]

  • Ji Ming Wang

• Baicalin (BA) is a flavonoid compound purified from medicinal plant Scutellaria baicalensis Georgi and has been shown to possess anti-inflammatory and anti-HIV-1 activities. In an effort to elucidate the mechanism of the anti-inflammatory effect of BA, we recently found that this flavonoid compound was able to form complexes with selected chemokine...

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• Characterization of hematopoietic progenitor cells following in vitro infection by Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8).

• Article

  • Mar 2000

  • Judy Mikovits

  • W Zhu

  • R Bagni

  • [...]

  • R Shoemaker

• View

• Hut 78 cell: DNA methyltransferase and HIV-1 infection

• Article

  • Jan 2000

  • JY Fang

  • Judy Mikovits

  • Rich Bagui

  • Francis Ruscetti

• View

• The DNA polymerase/processivity factor complex of Kaposi's sarcoma-associated herpesvirus: a novel target for high-through-put drug screening.

• Article

  • Nov 1999

  • Kai Lin

  • Judy Mikovits

  • RH Shoemaker

  • [...]

  • Robert Ricciardi

• View

• Comparison of cellular gene expression in Ebola-Zaire and Ebola-Reston virus-infected primary human monocytes

• Article

  • Nov 1999

  • C. Xiang

  • Howard A Young

  • H. Alterson

  • [...]

  • K. Anderson

• Ebola viruses are filamentous, enveloped, nonsegmented RNA viruses. Although most Ebola viruses, notably Ebola-Zaire virus, are highly infectious for primates and can cause severe haemorrhagic diseases, Ebola-Reston virus does not cause serious disease in humans. Microarray technology was employed to compare cellular gene responses to Ebola-Zaire a...

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• Mast Cell Migratory Response to Interleukin-8 Is Mediated Through Interaction With Chemokine Receptor CXCR2/Interleukin-8RB

• Article

  • Jun 1999

  • Gunnar Nilsson

  • Judy Mikovits

  • Dean Metcalfe

  • Daniel Dennis Taub

• To explore the role of chemokines in mast cell chemotaxis and accumulation at sites of inflammation, we first investigated the response of human mast cells to 18 different chemokines by induction of intracellular calcium mobilization in the human mast cell line, HMC-1. Only a subgroup of CXC chemokines defined by the conserved sequence motif glutam...

• View

• Mast Cell Migratory Response to Interleukin-8 Is Mediated Through Interaction With Chemokine Receptor CXCR2/Interleukin-8RB

• Article

  • May 1999

  • Gunnar Nilsson

  • Judy Mikovits

  • Dean Metcalfe

  • Daniel Dennis Taub

• To explore the role of chemokines in mast cell chemotaxis and accumulation at sites of inflammation, we first investigated the response of human mast cells to 18 different chemokines by induction of intracellular calcium mobilization in the human mast cell line, HMC-1. Only a subgroup of CXC chemokines defined by the conserved sequence motif glutam...

• View

• Anti-CD4 antibody attenuates interleukin-2 receptor signaling

• Article

  • Apr 1999

  • Jens Goebel

  • Kathy Forrest

  • A Franks

  • [...]

  • R P Lowry

• View

• INACTIVATION OF HTLV-1 INFECTIVITY WITH PRESERVATION OF FUNCTIONAL INTEGRITY OF VIRION SURFACE PROTEINS.

• Article

  • Apr 1999

  • Francis Ruscetti

  • Jeffrey Rossio

  • Judy Mikovits

  • Kathryn Suzanne Jones

• View

• PRODUCTIVE HUMAN RETROVIRAL INFECTION OF CD56+ HUMAN FETAL LIVER NK/LYMPHOID PROGENITOR CELL LINES

• Article

  • Apr 1999

  • Judy Mikovits

  • Robin Winkler

  • J. R. Ortaldo

  • Francis Ruscetti

• View

• Attenuation of IL-2 receptor signaling by CD4-ligation requires polymerized cytoskeletal actin but not P56LCK

• Article

  • Feb 1999

  • Jens Goebel

  • A Franks

  • F Robey

  • [...]

  • R P Lowry

• View

• +3

• Infection with Human Immunodeficiency Virus Type 1 Upregulates DNA Methyltransferase, Resulting in De Novo Methylation of the Gamma Interferon (IFN-g) Promoter and Subsequent Downregulation of IFN-g Production

• Article

• Full-text available

  • Oct 1998

  • Judy Mikovits

  • Howard A Young

  • PAULA VERTINO

  • [...]

  • Francis Ruscetti

• The immune response to pathogens is regulated by a delicate balance of cytokines. The dysregulation of cytokine gene expression, including interleukin-12, tumor necrosis factor alpha, and gamma interferon (IFN- g), following human retrovirus infection is well documented. One process by which such gene expression may be modulated is altered DNA meth...

• View

• ATTENUATION OF IL-2 RECEPTOR SIGNALING BY CD4-LIGATION - MOLECULAR MECHANISMS

• Article

  • Jun 1998

  • Jens Goebel

  • A Franks

  • F Robey

  • [...]

  • R P Lowry

• View

• +1

• Similar Levels of Human Immunodeficiency Virus Type 1 Replication in Human TH1 and TH2 Clones

• Article

• Full-text available

  • Jun 1998

  • Judy Mikovits

  • Daniel Dennis Taub

  • Susan M. Turcovski-Corrales

  • Francis Ruscetti

• Studies on the development and function of CD4+ TH1 and TH2 cells during the progression to AIDS may increase the understanding of AIDS pathogenesis. The preferential replication of human immunodeficiency virus (HIV) in either TH1 or TH2 cells could alter the delicate balance of the immune response. TH1 (gamma interferon [IFN-gamma] positive, inter...

• View

• ATTENUATION OF IL2 RECEPTOR SIGNALING BY CD4-LIGATION-MOLECULAR MECHANISMS

• Article

  • May 1998

  • Jens Goebel

  • A Franks

  • F Robey

  • [...]

  • R P Lowry

• View

• Attenuation of IL-2 signaling by CD4 ligand involves the cytoskeleton but does not require P56LCK.

• Article

  • Jan 1998

  • Jens Goebel

  • A Franks

  • F Robey

  • [...]

  • RP Lowry

• View

• X-I and X-II Open Reading Frames of HTLV-I Are Not Required for Virus Replication or for Immortalization of Primary T-Cellsin Vitro

• Article

  • Nov 1997

  • David Derse

  • Judy Mikovits

  • Francis Ruscetti

• In contrast to other retroviruses of the oncovirinae subgroup, the primate and bovine leukemia viruses (HTLV, STLV, and BLV) encode genes in the X-region of the genome, between the env gene and the 3' long terminal repeat. In HTLV-I, two overlapping open reading frames (ORFs) in the distal half of the X-region encode tax and rex genes, while two OR...

• View

• Vitamin E succinate induces Fas-mediated apoptosis in estrogen receptor-negative human breast cancer cells

• Article

• Full-text available

  • Apr 1997

  • J M Turley

  • T Fu

  • Francis Ruscetti

  • [...]

  • M C Birchenall-Roberts

• Vitamin E succinate (VES), a derivative of the fat-soluble vitamin D-alpha-tocopherol (vitamin E), inhibited growth and induced apoptotic cell death of estrogen receptor-negative human breast cancer cells. VES-induced apoptosis in MDA-MB-231 and SKBR-3 cells occurred through a Fas pathway. Total protein levels of the Fas receptor (Fas; APO-1/CD-95)...

• View

• Interruption of IL-2 receptor signaling by CD3-ligand HIV-gp120 binding.

• Conference Paper

  • Jan 1997

  • R. P. Lowry

  • Jens Goebel

  • P. Ghosh

  • [...]

  • F. Robey

• The manifest cytocidal and cytopathic activities of HIV on CD4+ T cells do not explain the global immunodeficiency of HIV infected individuals. Moreover, infusions of IL-2 have been associated with sustained increases in CD4 counts in these patients (Kovacs et al., N Engl J Med 332:567-75, 1995). Accordingly, in an effort to clarify the etiology of...

• View

• A Nuclear Matrix-Specific Factor That Binds a Specific Segment of the Negative Regulatory Element (NRE) of HIV-1 LTR and Inhibits NF-κB Activity

• Article

• Full-text available

  • Jun 1996

  • Tammy Hoover

  • Judy Mikovits

  • Dan Court

  • [...]

  • Raziuddin

• The negative regulatory element (NRE) of human immunodeficiency virus type-1 (HIV-1) long terminal repeat (LTR) is a defined region that has been reported to downregulate LTR-directed HIV gene expression. However, information on the precise role of this region in regulating HIV gone transcription is lacking. We have investigated the possibility tha...

• View

• In vitro infection of primary and retrovirus-infected human leukocytes by human foamy virus

• Article

• Full-text available

  • Jun 1996

  • Judy Mikovits

  • P M Hoffman

  • Axel Rethwilm

  • Francis Ruscetti

• The infectivity of human foamy virus (HFV) was examined in primary and cultured human leukocytes. Cell-free infectious viral stocks of HFV were prepared from the human kidney cell line 293 transfected with an infectious molecular clone of HFV. HFV productively infects a variety of human myeloid and lymphoid cell lines. In addition, primary cell cul...

• View

• Examining the Molecular Genetics of HTLV-I with an Infectious Molecular Clone of the Virus and Permissive Cell Culture Systems

• Article

  • May 1996

  • David Derse

  • Judy Mikovits

  • David Waters

  • [...]

  • Francis Ruscetti

• Infectious molecular clones of HTLV-I proviruses have only recently been reported. The long wait for such provirus clones reflects the difficulties inherent in propagating HTLV-I in vitro, and thus a rigorous demonstration of infectivity has awaited improved cell culture systems and sensitive detection techniques for HTLV-I. An intact HTLV-I provir...

• View

• Role of IgE Immune Complexes in the Regulation of HIV-1 Replication and Increased Cell Death of Infected Ul Monocytes: Involvement of CD23/FcdRII- Mediated Nitric Oxide and Cyclic AMP Pathways

• Article

• Full-text available

  • Jan 1996

  • Fatah Ouaaz

  • Francis Ruscetti

  • Baptiste Dugas

  • [...]

  • M. Djavad Mossalayi

• IgE/anti-IgE immune complexes (IgE-IC) induce the release of multiple mediators from monocytes/macrophages and the monocytic cell line U937 following the ligation of the low-affinity Fc epsilon receptors (Fc epsilon RII/CD23). These effects are mediated through an accumulation of cAMP and the generation of L-arginine-dependent nitric oxide (NO). Si...

• View

• Regulation of interferon-gamma gene expression: Multiple mechanisms of control.

• Article

  • Jan 1996

  • Howard A Young

  • Marco Cippitelli

  • Jianping Ye

  • [...]

  • Antonio Sica

• View

• MUTATIONS OF STRUCTURAL AND REGULATORY GENES IN AN INFECTIOUS MOLECULAR CLONE OF HTLV-I - DETERMINANTS OF INFECTIVITY AND T-CELL TRANSFORMATION

• Article

  • Oct 1995

  • D DERSE

  • Judy Mikovits

  • Francis Ruscetti

• View

• IN-VITRO INFECTION BY HUMAN FOAMY VIRUS - IMPLICATIONS FOR PATHOGENESIS IN HTLV-I AND HIV-I INFECTED OR UNINFECTED TARGET-CELLS

  • Oct 1995

  • Judy Mikovits   /   PM HOFFMAN   /   Axel Rethwilm   /   Francis Ruscetti

• Interaction of nuclear protein p140 with human immunodeficiency virus type 1 TAR RNA in mitogen-activated primary human T lymphocytes

• Article

• Full-text available

  • Sep 1995

  • C J Rothblum

  • J Jackman

  • Judy Mikovits

  • [...]

  • A Kumar

• Several lines of evidence suggest that cellular proteins play a role during human immunodeficiency virus type 1 (HIV-1) Tat-mediated trans activation. A recent report from this laboratory has shown that a 140-kDa HeLa nuclear protein (p140) binds specifically to the lower stem region of the Tat response element, TAR RNA. Since HIV-1 trans activatio...

• View

• cis-Acting Regulatory Elements in the Bovine Immunodeficiency Virus Long Terminal Repeat

• Article

  • Jul 1995

  • Steven E. Fong

  • Luke Pallansch

  • Judy Mikovits

  • [...]

  • Matthew Gonda

• Functional cis-acting regulatory elements in the bovine immunodeficiency virus (BIV) long terminal repeat (LTR) were identified by deletion mapping and nuclear protein gel shift analysis using three BIV-infectible cell lines, Cf2Th, BLAC-20, and EREp. Deletion mapping studies indicated that putative NF-kappa B, GRE, AP-4, AP-1, CAAT, and ATF/CRE tr...

• View

• Virions released from cells transfected with a molecular clone of human T- cell leukemia virus type I give rise to primary and secondary infections of T cells

• Article

• Full-text available

  • Apr 1995

  • D Derse

  • Judy Mikovits

  • Maria Polianova

  • [...]

  • Francis Ruscetti

• The ability of molecular clones of human T-cell leukemia virus type I (HTLV-I) to direct the synthesis of infectious virions has not previously been demonstrated. An HTLV-I provirus originating from an adult T-cell leukemia patient was cloned into a plasmid vector and is designated pCS-HTLV. This molecular clone was shown to direct the synthesis of...

• View

• Anti-Human Immunodeficiency Virus 1 (HIV-1) Activities of 3-Deazaadenosine Analogs: Increased Potency Against 3'-Azido-3'-Deoxythymidine-Resistant HIV-1 Strains

• Article

• Full-text available

  • Feb 1995

  • Douglas Mayers

  • Judy Mikovits

  • Bharat Joshi

  • [...]

  • R K Gordon

• 3-Deazaadenosine (DZA), 3-deaza-(+/-)-aristeromycin (DZAri), and 3-deazaneplanocin A (DZNep) are powerful modulators of cellular processes. When tested against H9 cells infected acutely with two different strains of human immunodeficiency virus 1 (HIV-1) and in the chronically infected monocytoid cell lines U1 and THP-1, the 3-deazanucleosides caus...

• View

• IL-4 and IL-13 have overlapping but distinct effects on HIV production in monocytes

• Article

  • Oct 1994

  • Judy Mikovits

  • Anne M. Meyers

  • John R. Ortaldo

  • [...]

  • Francis Ruscetti

• In HIV-1-infected monocytes and monocytoid cell lines, viral expression can be observed as high-level production, restricted (chronic low-level) expression, and latency (no viral expression). Interleukin-13 (IL-13) and IL-4, which have remarkedly similar deactivating effects on inflammatory monocyte functions, were studied for their regulation of H...

• View

• BIOLOGICAL CHARACTERIZATION OF A CLONED HTLV-I PROVIRUS

• Article

  • Apr 1994

  • D DERSE

  • Judy Mikovits

  • Maria Polianova

  • Francis Ruscetti

• View

• EVIDENCE FOR INFECTION IN RATS FOLLOWING EXPOSURE TO A MOLECULAR CLONE OF HTLV-I

• Article

  • Apr 1994

  • Kathryn Suzanne Jones

  • DS ROBBINS

  • DD DERSE

  • [...]

  • PM HOFFMAN

• View

• HTLV-1 INTERACTION WITH GLIAL-CELLS - IMPLICATIONS FOR HAM/TSP

• Article

  • Apr 1994

  • PM HOFFMAN

  • Judy Mikovits

  • KA BOUDREAU

  • [...]

  • S DHIBJALBUT

• View

===================

• Differential expression of Rel family members in human T-cell leukemia virus type I-infected cells: Transcriptional activation of c-rel by Tax protein

• Article

• Full-text available

  • Aug 1993

  • C.-C.H. Li

  • Francis Ruscetti

  • N R Rice

  • [...]

  • Dan Longo

• The Tax protein of the human T-cell leukemia virus type I (HTLV-I) has been shown to induce nuclear expression of Rel family NF-kappa B-binding proteins. However, under different experimental conditions, different J. H. Kim, Y. Daitoku, and W. G. Greene, J. Virol. 65:6892-6899, 1991). In this study, using specific immunological reagents capable of...

• View

full pDF : https://www.researchgate.net/publication/14689541_Differential_expression_of_Rel_family_members_in_human_T-cell_leukemia_virus_type_I-infected_cells_Transcriptional_activation_of_c-rel_by_Tax_protein 

1993-08-journal-of-virology-diff-expression-of-rel-family-members-tcell-li-ruscetti.pdf

Journal of Virology

• August 1993

• 67(7):4205-13

DOI:10.1128/JVI.67.7.4205-4213.1993

Differential Expression of Rel Family Members in Human

T-Cell Leukemia Virus Type I-Infected Cells:

Transcriptional Activation of c-rel by

Tax Protein

CHOU-CHI H. LI,1* FRANCIS W. RUSCETTI,2 NANCY R. RICE,3 EYING CHEN,1 NING-SUN YANG,4

JUDY MIKOVITS,' AND DAN L. LONGO2

Biological Carcinogenesis and Development Program, Program Resources, Inc. /Dyncorp, 1 Laboratory of

Leukocyte Biology, Biological Response Modifiers Program, Division of Cancer Treatment,2 Laboratory

of Molecular Virology and Carcinogenesis, ABL-Basic Research Program, 3 National Cancer Institute-

Frederick Cancer Research and Development Center, Frederick, Maryland 21702, and Agracetus,

Middleton, Wisconsin 535624

Received 7 January 1993/Accepted 21 April 1993

ACKNOWLEDGMENTS

We thank H. Temin for the c-rel promoter construct; W. Farrar

for the J-tax cell line; B. Felber and J. Harrison for the Tax plasmid

and assistance in the luciferase assay; T. Copeland and S. Oroszlan

for Tax antiserum; Raziuddin, R. M. Dai, and M. Korner for

consultations on EMSA; H. Phillips for help in tissue cultures; L.

Cheng and J. Sum for particle bombardment-mediated gene transfer;

and L. Martinez and T. Phillips for preparation of the manuscript.

============================

• Human T-cell leukemia virus type I infection of monocytes and microglial cells in primary human cultures

• Article

• Full-text available

  • Jan 1993

  • P M Hoffman

  • Suhayl Dhib-Jalbut

  • Judy Mikovits

  • [...]

  • Francis Ruscetti

• The pathogenesis of progressive spastic paraparesis [HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)], a serious consequence of human T-cell leukemia virus type I (HTLV-I) infection, is unclear. T and B lymphocytes can be naturally infected by HTLV-I, but the susceptibility to HTLV-I infection of other cell types that could cont...

• View

• 
  

==========

• Characterization and purification of a novel transcriptional repressor from HeLa cell nuclear extracts recognizing the negative regulatory element region of human immunodeficiency virus-1 long terminal repeat

• Article

• Full-text available

  • Jan 1993

  • M West

  • Judy Mikovits

  • G Princler

  • [...]

  • Raziuddin

• Cellular transcription factors play critical roles in regulating human immunodeficiency virus (HIV) gene transcription, although the precise mechanism(s) defining their roles are not well established. Primarily it has been suggested that sequence-specific interaction of trans-activating proteins with cis-acting DNA elements plays a crucial role in...

• View

https://www.researchgate.net/publication/21695718_Characterization_and_purification_of_a_novel_transcriptional_repressor_from_HeLa_cell_nuclear_extracts_recognizing_the_negative_regulatory_element_region_of_human_immunodeficiency_virus-1_long_termina

DOI:10.1016/S0021-9258(19)73989-1

THE Journal of Biological Chemistry

1993-01-the-journal-of-biological-chemistry-characterization-purification-nov-transcriptional-reprocessor-west-mikovits.pdf

Michael West$, Judy MikovitsS, Gerald Princlerg, Ya-LunL iuS, Frank W. Ruscettill,

Hsiang-Fu Kungg, and RaziuddinS I(

From the Laboratories of §Biochemical Physiology and YMolecular Immunoregulation, Biological Response Modifiers Program,

Division of Cancer Treatment, National Cancer Institute and the $Biological Carcinogenesis and Development Program,

Program Resources, Inc./DynCorp., Frederick Cancer Research and Development Center, Frederick, Marylund 21 702-1201

(Received for publication, June 23, 1992)

==================

• TheJournalofClinicalInvestigation,Inc. Volume90,October1992,1486-1491

• 1992-10-the-journal-of-clinical-investigation-mikovits.pdf

• Activation of infectious virus from latent Human Immunodeficiency Virus infection of monocytes in vivo

• also available at : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC443195/ 

• PMID: 1401081

• doi: 10.1172/JCI116016 

• Article

  • Nov 1992

  • Judy Mikovits

  • N C Lohrey

  • R Schulof

  • [...]

  • Francis Ruscetti

  • Activation of Infectious Virus from Latent Human Immunodeficiency Virus Infection of Monocytes In Vivo

  • JudyA.Mikovits,*NancyC.Lohrey, RichardSchulof, JaneCourtless, andFrancisW.Ruscettit
    *Biological Carcinogenesis and Development Program, Program Resources/DynCorp, Inc.; $Laboratory ofImmunoregulation, BiologicalResponseModifiersProgram,NationalCancerInstitute-FrederickCancerResearchandDevelopmentCenter,

  • Frederick, Maryland 21702-1201; and 1AIDS Clinical Trials Unit, George Washington University Medical Center, Washington, District ofColumbia 20037

• Individuals infected with HIV may be asymptomatic for years before progressing to overt AIDS. Since HIV can latently infect monocytoid cell lines, we examined whether HIV latency occurs in monocytes in vivo. Freshly isolated monocytes from asymptomatic seropositive individuals examined before and after culture were positive for HIV DNA, but not RNA...

• View

• Individuals infected with HIV may be asymptomatic for years before progressing to overt AIDS. Since HIV can latently infect monocytoid cell lines, we examined whether HIV latency occurs in monocytes in vivo. Freshly isolated monocytes from asymptomatic seropositive individuals examined before and after culture were positive for HIV DNA, but not RNA, as measured by polymerase chain reaction, showing that HIV latency occurs in monocytes in vivo. Coculture of these latently infected monocytes with Con A-activated T cells from HIV-negative normal donors stimulated 90% of the patients' samples and latently infected THP-1 to produce infectious virus. Neither Con A, resting T cells, nor T cell supernatants induced virus. Plasma membranes from activated T cells stimulated HIV production, suggesting cell contact induces factor(s) in monocytes to overcome latency. Thus, monocytes in AIDS patients harbor latent HIV inducible during an immune response, leading to T cell infection and viral-induced pathology.

==================

• 
  

• Negative regulation of human immunodeficiency virus type 1 expression in monocytes: Role of the 65-kDa plus 50-kDa NF-κB dimer

• Article

• Full-text available

  • Dec 1991

  • Raziuddin

  • Judy Mikovits

  • I Calvert

  • [...]

  • Francis Ruscetti

• Although monocytic cells can provide a reservoir for viral production in vivo, their regulation of human immunodeficiency virus type 1 (HIV-1) transcription can be either latent, restricted, or productive. These differences in gene expression have not been molecularly defined. In THP-1 cells with restricted HIV expression, there is an absence of DN...

• View

• Negative regulation of human immune deficiency virus replication in monocytes: Distinctions between restricted and latent expression in THP-1 cells

• Article

• Full-text available

• 
  

  • Jun 1990

  • Judy Mikovits

  • Raziuddin

  • Matthew Gonda

  • [...]

  • Francis Ruscetti

• In THP-1 monocytoid cells infected with HIV, viral expression can be regulated in several ways: (a) latency (no viral expression); (b) restricted expression (chronic low-level viral expression with little or no detectable virus released); and (c) continuous production. In cells with restricted HIV expression, nuclear factor(s) were found that block...

• View

• Interferon-Induced Activation of Latent Transforming Growth Factor? by Human Monocytes

• Article

  • Jun 1990

  • DANIEL R. TWARDZIK

  • Judy Mikovits

  • JANE E. RANCHALIS

  • [...]

  • Francis Ruscetti

• View

• Negative regulation of human immune deficiency virus replication in monocytes. Distinctions between restricted and latent expression in THP 1 cells

• Article

• Full-text available

  • May 1990

  • Judy Mikovits

  • Full list of authors, from PDF :   BY JUDY A. MIKOVITS,' RAZIUDDIN,` MATTHEW GONDA,T  MARTIN RUTA,1 NANCY C. LOHREYS HSIANG-FU KUNG,N   AND FRANCIS W. RUSCETTIS

  • From the 'Department of Biological Carcinogenesis Development Program and the TLaboratory of

  • Cell and Molecular Structure, Program Resources, Inc . ; the SLaboratory of Molecular

  • Immunoregulation and the Il Laboratory of Biochemical Physiology, National Cancer Institute,

  • Frederick Cancer Research Facility, Frederick, Maryland 21701; and the Division of Blood and

  • Blood Products, Centers for Biologic Evaluation and Research, Bethesda, Maryland 20892

  • SO... "Program Resources, Inc." is DynCorp 

  • Article in Journal of Experimental Medicine (JEM) · May 1990

  • DOI: 10.1084/jem.171.5.1705

  • 1990-05-journal-of-experimental-medicine-negative-regulation-hiv-relication-in-monocytes-mikovits.pdf

  • Downloaded form : https://www.researchgate.net/publication/246560128_Negative_regulation_of_human_immune_deficiency_virus_replication_in_monocytes_Distinctions_between_restricted_and_latent_expression_in_THP_1_cells 

• In THP-1 monocytoid cells infected with HIV, viral expression can be regulated in several ways: (a) latency (no viral expression); (b) restricted expression (chronic low-level viral expression with little or no detectable virus released); and (c) continuous production. In cells with restricted HIV expression, nuclear factor(s) were found that block...

•