Dr. Bernhard Fleischer (born 1950)
born on December 25, 1950 in Leipzig, Germany [HL009L][GDrive]
Married : " Sabine (Rott) Fleischer" (daughter of Prof. Rudolf Rott (born 1926) )
"[Rudolph] Rott was married to Renate Kröll since 1956 and has a daughter Sabine, who is married to the former director of the Bernhard Nocht Institute [Dr. Bernhard Fleischer (born 1950)]." See [HK005F][GDrive]
ASSOCIATIONS
Prof. Rudolf Rott (born 1926) - [Dr. Bernhard Fleischer (born 1950)] has collaborated with [Prof. Rudolf Rott (born 1926)] on research; [Dr. Bernhard Fleischer (born 1950)] is also the son-in-law of [Prof. Rudolf Rott (born 1926)], having married Rott's daughter Sabine.
- ASSOCIATIONS (employers)
Bernhard Nocht Institute for Tropical Medicine -- " In 1993 [Dr. Bernhard Fleischer (born 1950)] became a professor for tropical medicine and immunology at the University of Hamburg. From 1993 he was head of department and from 1996 to 2007 director of the [Bernhard Nocht Institute for Tropical Medicine] (which has been managed by a foundation board since 2008), to whose board he then changed." [HK00B0][GDrive]
ASSOCIATIONS (Events)
Bernhard Fleischer (born December 25, 1950[1] in Leipzig) is a German physician, parasitologist and immunologist.
Fleischer studied medicine and received his doctorate in human medicine in 1977 at the University of Gießen under Hansjürgen Staudinger (See https://de.wikipedia.org/wiki/Hansj%C3%BCrgen_Staudinger ) .[2] He is a specialist in microbiology and infection epidemiology. In 1993 he became a professor for tropical medicine and immunology at the University of Hamburg. From 1993 he was head of department and from 1996 to 2007 director of the [Bernhard Nocht Institute for Tropical Medicine] (which has been managed by a foundation board since 2008), to whose board he then changed.[3] Until 2017, he was also director of the Institute for Immunology at the University Hospital Hamburg-Eppendorf. He declined calls to the Chair of Immunology at the University of Düsseldorf (1991), to the Chair of Medical Microbiology at the University of Marburg (1996) and to the Chair of Microbiology and Hygiene at the University of Cologne (1997).
In the late 1980s, he was one of the first to describe superantigens.
Bernhard Fleischer is a member of the Leopoldina (since 1995)[4] and a member of the Academy of Sciences in Hamburg. In 1983 he received the advancement award and in 1992 the award from the German Society for Hygiene and Microbiology, in 1986 the Arthur Pappenheim Prize[5] from the German Society for Hematology and Oncology (together with A. Rhagavachar), in 1990 the Science Prize for Basic Medical Research from the GSK Foundation,[5] in 1993 the Robert Koch Promotional Prize,[6] in 1997 the Aronson Prize[7] and in 2016 the Badge of Honor of the Danylo Halytsky National Medical University, Lviv, Ukraine. He is married and has three children. Since 2014 he has been secretary of the German Society for Tropical Medicine, Travel Medicine and Global Health e.V. (DTG).
Writings
Editor with Rudolf Rott: Problems of Important Tropical Infectious Diseases, Nova Acta Leopoldina, Volume 80, No. 313, 2000 (Leopoldina Symposium with the Bernhard Nocht Institute, February 1999 in Hamburg)
with Rudolf Rott: Combating tropical infectious diseases, Naturwissenschaften Rundschau, 2002, Issue 3, Supplement, pp. 1-2 (Leopoldina News No. 9)
Editor with Hans Olof Sjögren: Superantigens, Springer Verlag 1991
Stimulation of the immune system by microbial "superantigens", Immunity and Infection, Vol. 19, 1991, pp. 8-11
Stimulation of human T-cells by microbial "superantigens" Immunologic Research, Vol. 10, 1991, pp. 349-355
Superantigen, Deutsches Ärzteblatt, Volume 88, Issue 42, 1991 pdf
Superantigens, Acta Pathologica, Microbiologica et Immunologica Scandinavica, Vol. 102, 1994, pp. 3-12
Bernhard Fleischer, German medical facility administrator, educator, scientist. Diplomate in medical microbiology. Recipient Junior Scientist award German Society for Microbiology and Hygiene, 1983, Pappenheim prize German Society for Hematology, 1986, Medical Research award SmithKline Beecham Beecham Foundation, 1990, Promotional award Robert Koch Foundation, 1993, Aronson prize State of Berlin, 1997, others.
Background
Fleischer, Bernhard was born on December 25, 1950 in Leipzig, Germany.
Education
Doctor of Medicine, University giessen, Germany, 1977.
Career
Postdoctoral fellow, Institute for Virology/U. Giessen, 1977-1979; postdoctoral fellow, Institute for Virology and Immunobioogy/U. Würzburg, Germany, 1979-1983; assistant professor department medical microbiology and immunology, U. Ulm, Germany, 1983-1986; associate professor, U. Ulm, Germany, 1986-1987; associate professor 1st department medicine, U. Mainz, Germany, 1987-1993; professor, U. Hamburg, Germany, since 1993; department chairman medical microbiology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, since 1993; vice director, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, 1994-1996; director, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, since 1996. Member of advisory board German Institute for Medical State Examinations, since 1991.
Membership
Member American Association Immunologists, American Society for Microbiology, German Society Hygiene and Microbiology (advisory board since 1994), German Society for Immunology (advisory board), Academy of Sciences of 1794 (Erfurt), German Academy of Sciences Leopoldina.
Connections
Married Sabine Fleischer. Children: Lennart, Henrike, Wiebke.
Spouse : Sabine Fleischer
child : Lennart Fleischer
child : Wiebke Fleischer
child : Henrike Fleischer
Born : December 25, 1950 in Leipzig, Germany
Nationality : German
Ethnicity : German
Education
1977
University Giessen , Doctor of Medicine
Career
1977 - 1979 : Postdoctoral fellow , Institute for Virology/U. Giessen
1979 - 1983 : Postdoctoral fellow , Institute for Virology/U. Giessen , Germany
1983 - 1986 : assistant professor department medical microbiology and immunology , University Ulm , Germany
1987 - 1993 : associate professor 1st department medicine , University Mainz, Germany
1993 : professor , University Hamburg, Germany
1993 : Chairman department medical microbiology , Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany, Germany
2018 (March 19) - "Bernhard Fleischer Visiting Professor in the Department of Medical Genetics at Yerevan State Medical University"
Saved PDF : [HE009Z][GDrive]
Since November 30, 2017 Bernhard Fleischer, Professor at Bernhard Nocht Institute, has become Visiting Professor of Medical Genetics at Yerevan State Medical University.
Bernhard Fleischer is a German physician, parasitologist and immunologist. He received his medical education at the Universities of Giessen and Hamburg. In 1993 he became professor of tropical medicine and immunology at the University of Hamburg then he became Director of the Institute of Immunology at the University Medical Center Hamburg-Eppendorf.
During different periods of professional career, Professor Fleischer worked in some of the most popular and top-ranking universities in Germany and directed [Bernhard Nocht Institute for Tropical Medicine], Hamburg.
Bernhard Fleischer is a member of the Leopoldina (since 1995) and a member of the Academy of Sciences in Hamburg. In 1992 he was awarded the prize of the German Society for Hygiene and Microbiology, and in 1997 he was awarded the Aronson Prize.
The Professor participated in numerous international conferences and his articles were published in the world’s most famous journals.
https://www.leopoldina.org/fileadmin/redaktion/Mitglieder/CV_Fleischer_Bernhard_D.pdf
Curriculum Vitae Prof. Dr. med. Bernhard Fleischer Name: Geboren: Bernhard Fleischer 25. Dezember 1950 Forschungsschwerpunkte: Superantigene, Lymphozyten, Immunabwehr, tropische Infektionserreger, Epidemiologie Bernhard Fleischer ist ein deutscher Mediziner, Parasitologe und Immunologe. Er ist Leiter des Nationalen Referenzzentrums für tropische Infektionserreger am Bernhard‐Nocht‐Institut in Hamburg. Seine Schwerpunkte liegen in der zellulären Immunologie und medizinischen Mikrobiologie mit besonderem Fokus auf sogenannte Superantigene, die er Ende der 1980er Jahre als einer der Ersten beschrieb. Akademischer und beruflicher Werdegang seit 2008 seit 2002 seit 2002 1996 ‐ 2007 seit 1993 1990 1987 1986 1985 1977 Mitglied im Vorstand des Bernhard‐Nocht Instituts für Tropenmedizin und Leitung der Sektion Immunologie Direktor des Instituts für Immunologie am Universitätsklinikum Hamburg‐Eppendorf Leitung des Nationalen Referenzzentrums für tropische Infektionserreger am Bernhard‐Nocht‐Institut in Hamburg Direktor des Bernhard‐Nocht‐Instituts für Tropenmedizin in Hamburg Professor für Tropenmedizin und Immunologie an der Universität Hamburg Facharzt für Mikrobiologie und Infektionsepidemiologie Professur an der Universität Mainz Professur an der Universität Ulm Habilitation an der Universität Gießen Promotion an der Universität Gießen
1970 ‐ 76 Studium der Humanmedizin an den Universitäten Hamburg und Gießen Funktionen in wissenschaftlichen Gesellschaften und Gremien 2012 ‐ 14 Vorsitzender und seit 2005 Mitglied des Auswahlausschusses zur Vergabe von Georg Forster‐Forschungspreisen und ‐stipendien der Alexander‐von‐ Humboldt‐Stiftung Kuratoriums‐Mitglied der Werner‐Otto‐Stiftung Projektkoordination, Mitgliedschaft in Verbundprojekten 2006 ‐ 2009 2004 ‐ 2018 1996 ‐ 2000 1979 ‐ 2004 Leiter des DFG SFB 470 Teilprojekts „Molekulare Interaktion von Siglecs mit sialylierten Liganden auf Trypanosoma cruzi und deren Bedeutung für die Regulation der Immunabwehr (C11)“ Antragsteller des DFG‐Projekts „Analyse der regulatorischen Funktion von CD83 auf B‐Lymphozyten“ Antragsteller des DFG‐ Schwerpunktprogramms „Induktion und Aufrechterhaltung der Wirt‐Zell‐Proliferation durch die intrazellulären Parasiten Theileria annulata und Theileria parva“ Leiter des DFG SFB 545 Teilprojekts „Alternative Aktivierung von T‐Lymphozyten (B 8)“ Auszeichnungen und verliehene Mitgliedschaften seit 2009 1997 seit 1995 1993 seit 1992 1992 1990 1990 1986 Mitglied der Akademie der Wissenschaften in Hamburg Aronson‐Preis des Landes Berlin für herausragende Leistungen in der Mikrobiologie und Immunologie Mitglied der Nationalen Akademie der Wissenschaften Leopoldina Robert Koch‐Förderpreis der Universität Clausthal‐Zellerfeld Auswärtiges Mitglied der Akademie gemeinnütziger Wissenschaften zu Erfurt von 1754 Hauptpreis der Deutschen Gesellschaft für Hygiene und Mikrobiologie Preisträger „Medizinische Grundlagenforschung“ der GlaxoSmithKline Stiftung Wissenschaftspreis für Medizinische Grundlagenforschung der Stiftung Knochenmark‐ und Stammzellspende Deutschland Arthur Pappenheim‐Preis der Deutschen Gesellschaft für Hämatologie und Onkologie
Bernhard Fleischer hat sich durch Entdeckungen auf dem Gebiet der zellulären Immunologie ausgezeichnet. Einer seiner wichtigsten Beiträge war die Aufklärung des Wirkungsmechanismus der so genannten Superantigene Ende der 1980er Jahre. Diese hauptsächlich von Bakterien gebildeten Moleküle wirken toxisch auf unser Immunsystem und werden mit einer Reihe tödlicher Krankheiten wie dem toxischen Schocksyndrom mit nachfolgendem Multiorganversagen und diversen Lebensmittelvergiftungen in Verbindung gebracht. Der Name „Super‐Antigene“ beschreibt die Eigenschaft der Moleküle, wie Antigene eine Immunreaktion auszulösen. Dabei reichen schon wenige Moleküle aus, um eine „super“starke Stimulation derjenigen weißen Blutzellen auszulösen, die für die erworbene Immunantwort zuständig sind, die so genannten T‐Lymphozyten oder kurz T‐Zellen. Auch der Analyse der Funktion und Spezifität dieser T‐Lymphozyten bei Infektionen und Autoimmunerkrankungen widmete sich Fleischer in seinen Forschungen, ebenso wie der Beschreibung neuer Signalwege in T‐Lymphozyten und der Immunantwort gegen tropische Parasiten.
2000 (September) - "100 years of tropical medicine in Hamburg at the Bernhard Nocht Institute", written by Bernhard Fleischer
PMID: 11142708
The Bernhard Nocht Institute (BNI) is a four months younger and much smaller sibling of the Instituto Oswaldo Cruz. It was founded on 1 October 1900 as an Institut für Schiffs- und Tropenkrankheiten (Institute for Maritime and Tropical Diseases) and was later named after its founder and first director Bernhard Nocht. Today it is the Germany’s largest institution for research in tropical medicine. It is a government institution affiliated to the Federal Ministry of Health of Germany and the Department of Health of the State of Hamburg. As the center for research in tropical medicine in Germany the BNI is dedicated to research, training and patient care in the area of human infectious diseases, which are of particular relevance in the tropics. It is the primary mission of the BNI to develop means to the control of these diseases. Secondary missions are to provide expertise for regional and national authorities and to directly and indirectly improve the health care for national and regional citizens in regard to diseases of the tropics.
For full article, See : Bernhard Nocht Institute for Tropical Medicine
2003 (March 27) - The Bismarck Tribune : Includes mention of"Bernhard Nocht"
Note : Director of Bernhard Nocht Institute is Dr. Bernhard Fleischer (born 1950)
2003 (APril 11) - Gerberding ...
https://www.newspapers.com/image/248545972/?terms=%22Bernhard%20Nocht%22&match=1
https://pubmed.ncbi.nlm.nih.gov/12682141/
https://journals.asm.org/doi/10.1128/JCM.41.4.1529-1535.2003
Article :
HISTORY
Received: 11 October 2002
Revision received: 31 December 2002
Accepted: 13 January 2003
Published online: 1 April 2003
J Clin Microbiol
. 2003 Apr;41(4):1529-35. doi: 10.1128/JCM.41.4.1529-1535.2003.
Detection, differentiation, and quantitation of pathogenic leishmania organisms by a fluorescence resonance energy transfer-based real-time PCR assay
Alexandra Schulz 1, Katja Mellenthin, Gabriele Schönian, Bernhard Fleischer, Christian Drosten
Affiliations expand
PMID: 12682141
PMCID: PMC153923
Free PMC article
Abstract
Real-time technology eliminates many of the pitfalls of diagnostic PCR, but this method has not been applied to differentiation of Leishmania organisms so far. We have developed a real-time PCR that simultaneously detects, quantitates, and categorizes Leishmania organisms into three relevant groups causing distinct clinical pictures. The analytical sensitivity (detection rate of >or=95% at 94.1 parasites/ml of blood) was within a range that has been determined previously to facilitate the confirmation of visceral leishmaniasis from peripheral blood. Parasites were successfully detected in 12 different clinical samples (blood, bone marrow, skin, and liver). The Leishmania donovani complex, the Leishmania brasiliensis complex, and species other than these could be clearly discriminated by means of distinct melting temperatures obtained with fluorescence resonance energy transfer probes (melting points, 72.7, 67.1, and 65.0 degrees C, respectively). All three groups could be quantified within equal ranges. As in other real-time PCRs, the variability in the quantification of DNA was small (coefficient of variation [CV], <2%). However, human samples containing low levels of parasites (100 parasites per ml of blood) showed higher variation (CV, 60.89%). Therefore, despite its superior analytical performance, care must be taken when real-time PCR is utilized for therapy monitoring.
Acknowledgments
We are grateful to Patty Wilkins, Gisela Bretzel, and Joachim Clos for providing cultured Leishmania parasites and to Nadine Petersen, Britta Liedigk, and Anne McDonald for excellent technical assistance. We thank Stephan Günther for critical reading of the manuscript.
This work was supported by the German Ministry of Health as part of funding of the National Reference Center for Tropical Infections.
2003 (April 13) - The Fort Collins Coloradoan : "SARS Outbreak - German Institute professor leads search for vaccine to stop disease"
Clip saved as PDF with OCR : [HN029O][GDrive] / Allso see - 2002-2004 SARS outbreak / Dr. Bernhard Fleischer (born 1950) /
Editor's note: At the end of March [2003], only two months after we learned about the outbreak of severe acute respiratory syndrome, or SARS, in southern China, professor [Dr. Bernhard Fleischer (born 1950)] of the [Bernhard Nocht Institute for Tropical Medicine] in Hamburg, Germany, discovered a virus believed to be responsible for causing the disease. Eliza Sarnacka-Mahoney, a freelance journalist from Fort Collins, talked with Fleischer last week. Following are excerpts from that interview.
QUESTION: Is research to create a vaccine well under way?
[Dr. Bernhard Fleischer (born 1950)]: As far as I know, yes. But for whatever reason, the (World Health Organization) still remains somewhat reluctant to admit it is the new coronavirus that causes SARS and so has not included it as criteria for the disease yet. I hope they will do it soon, for it will signal a green light for many more scientists around the world who are presently waiting for that ''official'' decision. As it is with many more dangerous viruses, we need a vaccine against it to start working toward eliminating SARS from our lives someday. ... Seeing how the epidemic is unfolding in China and Hong Kong gives us an ever-clearer understanding how hard it is to contain this infection. ... And if this is the case, then the disease will spread all over the world and will be with us for some time.
QUESTION: The way the virus travels is another mystery. We have been hearing that it can have various levels of infectiousness, depending on a geographical location. Apparently, SARS is more contagious in Asia than in the United States?
ANSWER: Well, that's the way it was/is presented by the media. But really ... some people turn out to be more contagious than others. ... Yet we do not know why some people are better transmitters than others and why some do not spread the virus at all, even though they have it and fall ill themselves. The press reported on a man from Hong Kong whose body produced 100,000 times more copies of the virus than an average SARS patient. It turned out he had been recovering from an organ transplant and was taking immunosuppressing drugs. His immune system worked differently. We can suspect then, that people with any kind of an immune system deficiency are better transmitters than others. Since it is impossible to determine such things at first glance or contact ... all patients undergo the same kind of quarantine and are hospitalized. Fortunately for us, we also have a very good test.
QUESTION: How does the test work?
ANSWER: It's a very fast PCR (Polymerase Chain Reaction) test. It is extremely sensitive, so you could detect very few copies of the virus, and you'll know within an hour whether the person has the virus or not. To compare, antibodies, which could be another way of determining the infection, appear in the patient's bloodstream only a day after he has been infected.
QUESTION: How long is the incubation period for this new virus?
ANSWER: Three to five days. If you do not show symptoms after seven days, you probably are fine. If nothing occurs after 10 days, then you do not carry the virus
QUESTION: When you announced to the world that your scientists have identified the virus behind SARS, you also said you did not believe we were heading for a global SARS epidemic. Do you still think that?
ANSWER: Well, I thought so early on ... but I am very doubtful now. Perhaps nobody expected the virus to be as contagious as it has proven to be. Now, I think that SARS is going to be a problem for medical communities around the world for quite a while and that a global epidemic is possible, even if we do have the vaccine very soon.
QUESTION: Very soon, meaning when?
ANSWER: Available within a year or so. The work is proceeding extremely fast this time. It has only been two months from the first note that there is this new disease going around, and we have already identified the responsible agents. Such speed is unprecedented in medical history. On the other hand, it is very likely that a vaccine might not be ready for the next few years.
QUESTION: While we wait, is there anything we can do to protect ourselves from SARS?
ANSWER: Unfortunately, I don't think there's much we can do. People who find themselves in the centers of the epidemic or have to travel there should definitely take precautions - wear masks, wash their hands frequently and avoid crowds, if possible. On the other hand, we should not panic too much. If you consider that in a city of 10 million people you have 100 people who are infectious running around, your chances of getting the virus are only 1 in 100,000. Most patients fully recover from SARS within two weeks. Those who have died from it were patients with other medical conditions affecting their respiratory and immune systems.
QUESTION: Do you think that involuntary quarantine - even of potentially healthy individuals - such as has been done in Toronto, San Jose and Hong Kong, is the best method to fight this and any future infections?
ANSWER: Let's start with the fact that any quarantine requires cooperation of the people. If we have that, then it will always be a great help. But people are people, and you have to expect that they may not want to make themselves visible for whatever reason. Personally, I support it. We have had only three SARS cases in Germany so far; we treated those people and now we haven't seen any secondary cases, something that did happen in other countries, for example, in the United Kingdom.
Q; What about herbal remedies - for example, echinacea? Many people believe they help boost our immune system and fight diseases. Would taking such supplements help reduce the likelihood of infection, or - at least - the severity of the infection?
ANSWER: It is difficult to answer. There are many things that influence our immune system: eating habits, exercise, perhaps herbs, but nobody is sure in which way exactly or how it works. So until there are answers backed up by reliable research, it has to remain a personal choice.
QUESTION: The new virus has, in a way, laughed in the face of modern medicine, reminding us that the battle with microbes is still on in spite of all the resources we have against them. Should it also be a warning that one day we might be hit by an epidemic comparable in size and potency to the influenza of 1918?
ANSWER: I don't think we will face anything like 1918 again. But it is extremely important that we keep on fighting, because the reality is that the more vaccines we create, the more clever the viruses get. Microbes keep fmding ways to overcome weapons we have against them. Their resistance toward tuberculosis treatment is what comes to mind immediately, and - let's admit it - the recent TB outbreaks are bigger problems than SARS. Microbes keep outwitting us. They become resistant to a new drug that becomes available extremely quickly, within just one year, as in the current cases of malaria or HIV. Not so long ago, a new vaccine was good for a decade.
2003 (May 12) - Drosten / SARS ...
https://www.newspapers.com/image/417695145/?terms=Fleischer%20sars%20bernhard&match=2
Shope / Denison / Drosten
https://www.newspapers.com/image/860720799/?terms=sars%20bernhard&match=1
https://www.newspapers.com/image/583674573/?terms=sars%20bernhard&match=1
The Santa Fe New Mexican
18 Apr 2003, Fri · Page 17
https://en.wikipedia.org/wiki/Bernhard_Nocht_Institute_for_Tropical_Medicine
...mentions directorship, 1996 to 2007 ...
one of 2 BSL4 labs in germany in 2001 - https://www.newspapers.com/image/357184276/?terms=%22Bernhard%20Nocht%22&match=1