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Our lab is split into two teams. Team azirine and team sugar! Read more about each below.
Synthesis and Reactivity of α,β-unsaturated 2H-azirines
Synthesis and Reactivity of α,β-unsaturated 2H-azirines
Our research investigates the unique reactivity of 2H-azirines and how the properties can be predictably tuned through molecular design. These strained, highly reactive motifs are then leveraged as versatile intermediates and as potential electrophilic “warheads” in chemical biology applications, enabling new strategies for selective labeling and probing of biological systems.
Synthesis of rare bacterial amino-sugars
Synthesis of rare bacterial amino-sugars
Rare bacterial amino-sugars are types of sugars exclusively biosynthesized by specific bacteria. These sugars are considered "synthetically inaccessible" by chemists due to the challenging nature of certain chemical manipulations on this scaffold. Carbohydrate-based, de novo, and chemoenzymatic strategies have been the most used in research, which has vastly improved our knowledge of the biological roles of these complex scaffolds. We aim to complement this research by producing these sugars through higher yielding, scalable synthetic organic routes.
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