We will engineer mammalian cells with advanced gene-editing tools to create 'designer cells'. These cells could be used as cell-based therapeutics and tools for biological research. Additionally, we aim for developing gene-therapy platforms to treat refractory diseases.
Embedded Files
1. Gene editing
New methods for highly efficient knockin-based gene editing.
Base editing and prime editing for the generation of various cell lines.
2. Synthetic biology
Construction of stimuli-responsive genetic circuits for precise control of gene expression.
Application of the genetic circuits to design biopharmaceuticals.
3. Cell therapy
Designer stem cell-derived β cells and islet organoids for treating diabetes.
Gene editing-based safety switches for cell-based therapeutics.
4. Gene therapy
Development of therapeutic genes based on intracellular binders such as nanobodies and affibodies.
Targeted protein degradation and relocalization through gene delivery.
We are supported by
Page updated
Report abuse