Epigenetic pathol-mechanisms and RNA methylation
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Po-Hsien J Huang, PhD
Associate Professor
Department of Biochemistry and Molecular Biology
National Cheng Kung University
Purpose
Purpose
Our lab aims to understand the DNA methylation basis of the cancer genome and to explore whether epigenetic and epitranscriptomic mechanisms can prevent cancer progression and skeletal muscle wasting.
Our Research
Our Research
A few highlights of our work below:
DNA methylation and cancer pathology: a mechanistic bridge leading to the identification of potential targets for precision epigenetic therapy and better diagnostic tools for aggressive tumors.
RNA methylation and cancer: Mechanisms by which m⁵C impacts gene expression and epithelial differentiation in cancer.
Cancer cachexia: Role of tumor-secreted factors CHI3L1 and immune signaling in promoting muscle wasting.
Selected Publications
Selected Publications
2025 - Oncogene
2025 - Oncogene
Chang CJ, Huang PH, Chen SY, Su PC, Ding LY, Hou YC, Hung MN, Chen KL, Wu YN, Wu SR, Lin FC, Lu PJ, Wu HY, Chen YJ, Chang CH, Chang CP, Hwang DY, Wang YC, Shan YS.
2024 - Scientific Data
2024 - Scientific Data
Chen SY, Fang YH, Huang CY, Wu JH, Shan YS, Liu YW and Huang PH
2024 - American Journal of Pathology
2024 - American Journal of Pathology
Ding LY, Chang CJ, Chen SY, Chen KL, Li YS, Wu YC, Hsu TY, Ying HY, Wu HY, Hughes MW, Wang CY, Chang CH, Tang MJ, Chuang WJ, Shan YS, Chang CJ, and Huang PH
2022 - Oncogene
2022 - Oncogene
Chen SY, Chen KL, Ding LY, Yu CH, Wu HY, Chou YY, Chang CJ, Chang CH, Wu YN, Wu SR, Hou YC, Lee CT, Chen PC, Shan YS, and Huang PH
2020 - Clinical Epigenetics
2020 - Clinical Epigenetics
Ding LY, Hou YC, Kuo IY, Hsu TY, Tsai TC, Chang HW, Hsu WY, Tsao CC, Tian CC, Wang PS, Wang HC, Lee CT, Wang YC, Lin SH, Hughes MW, Chuang WJ, Lu PJ, Shan YS, and Huang PH
2013 - Cancer Cell
2013 - Cancer Cell
Weischenfeldt J, Simon R, Feuerbach L, Schlangen K, Weichenhan D, Minner S, Wuttig D, Warnatz HJ, Stehr H, Rausch T, Jäger N, Gu L, Bogatyrova O, Stütz AM, Claus R, Eils J, Eils R, Gerhäuser C, Huang PH, Hutter B, Kabbe R, Lawerenz C, Radomski S, Bartholomae CC, Fälth M, Gade S, Schmidt M, Amschler N, Haß T, Galal R, Gjoni J, Kuner R, Baer C, Masser S, von Kalle C, Zichner T, Benes V, Raeder B, Mader M, Amstislavskiy V, Avci M, Lehrach H, Parkhomchuk D, Sultan M, Burkhardt L, Graefen M, Huland H, Kluth M, Krohn A, Sirma H, Stumm L, Steurer S, Grupp K, Sültmann H, Sauter G, Plass C, Brors B, Yaspo ML, Korbel JO, Schlomm T
2012 - American Journal of Pathology
2012 - American Journal of Pathology
Krohn A, Diedler T, Burkhardt L, Mayer PS, De Silva C, Meyer-Kornblum M, Kötschau D, Tennstedt P, Huang J, Gerhäuser C, Mader M, Kurtz S, Sirma H, Saad F, Steuber T, Graefen M, Plass C, Sauter G, Simon R, Minner S, Schlomm T
2011 - Carcinogenesis
2011 - Carcinogenesis
Arab K, Smith LT, Gast A, Weichenhan D, Huang J, Claus R, Hielscher T, Espinosa AV, Ringel MD, Morrison CD, Schadendorf D, Kumar R, Plass C
Our Team
Our Team
Dr Po-Hsien J Huang 黃柏憲 博士 / PI Show profile →
Dr Szu-Ying Chen 陳思穎 博士 / Postdoctoral Scholar
Research Associate
PhD Program
Master Program
Wei Kuo 郭 葳 /宜蘭大學生物技術與動物科學系
Yu-Ching Weng 翁郁晴 /義守大學醫學檢驗技術學系
Wen-Qi Lin 林玟其 /中國醫藥大學藥妝系
Wen-Ling Xue 薛芠淩 /中興大學食品暨應用生物科技學系
Yu-Wei Feng 馮宇薇 /長庚大學生物醫學系
Kuan-Chen Li 李冠辰 /中正大學生物醫學科學系
Contact us
Contact us
黃柏憲 副教授
電子郵件: phhuang@mail.ncku.edu.tw
實驗室地址 : 70101 臺南市東區大學路1號 國立成功大學 醫學院生化所
電話 : (06) 235 3535 分機 5517 (研究室) 或 5511 (實驗室)
Dr Po-Hsien J. Huang
E-mail: phhuang@mail.ncku.edu.tw
Department of Biochemistry and Molecular Biology, National Cheng Kung University
Address:
1 University Road,
Medical College Building, 9F, R82-0903
Tainan City 70101, Taiwan
Phone: +886 (0)6 235 3535 ext. 5517 (office) or 5511 (Lab)
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