1. Employing SLA 3D printing and CT image-based design techniques aims to enhance the stability of the fusion cage. 

2. Evaluating the long-term effects of incorporating small molecular drug, simvastatin, into 3D printing resin for fabricating implants.

1. Studying the effect of liposomal drug on cancer therapy, with a focus on medications administered by inhalation.

2. Analyze the particle size, polydispersity index(PI) and zeta potential of nanoparticles.

3. Analyze drug encapsulation efficiency (EE%), loading capacity (LC%) and release from nanoparticles.

4. In vitro cell study, observe LLC cells survival status to assess drug efficacy.

5. In vivo animal study, using C57BL/6 mice establish lung cancer model and evaluate inhaled liposome drug efficacy.

1. Preparation of hydroxyapatite (HAP) micro-particle for incorperation of PDL1 and CTLA4 checkpoint inhibitors

2.  Endocytosis of HAP-PDL1 and HAP-CTLA4 by macrophgy, producing exosomal loaded PDL1 and CTLA4

3. Intra-nasal administration of Exo-PDL1 and Exo-CTLA4 for glioma immunotherapy 

4. Enhancing the concentration of M1 macrophage and Cytotoxic T cell in brain

1.Photo-crosslinked hydrogel prevents nucleus pulposus leakage following intervertebral disc injury .

2.A hydrogel scaffold loaded with FG4592 enhances HIF-1α expression, promoting nucleus pulposus regeneration. 

3.MRI, micro-CT, immunohistochemistry, and RT-PCR are used to assess intervertebral disc regeneration. .