In cooperation with both chemical and biological technologies, to efficiently utilize microbial genomes for making drugs of medical and industrial values.
To construct and integrate databases of microbial genomics, proteomics, metabolomics, chemical libraries and functional genomics.
Functional Genomics of Natural Products Biosynthesis
Identification, Molecular Cloning and Functional Expression of Bioactive Natural Products.
To explore biosynthetic network, gene and enzymes
Combinatorial Biosynthesis and Genetics of the Natural Products Biosynthetic Gene Clusters.
Pathway Engineering of Microorganisms for Biotransformation and Biocatalysis.
Bioassays of the Novel or Engineered Molecules for Drug Discovery.
Overproduction of the Identified Molecules by Engineered Microbial Hosts.
Engineering of Bioactive Molecules by Microbial Enzymes
Chemo-Enzymatic Synthesis of Various NDP-sugars
Chemo-Biosynthesis and Precursor-Directed Biosynthesis of Aglycones of Bioactive Molecules
Engineering of Bioactive Glycosides by Native or Engineered Glycosyltransferases
Engineering of other Bioactive Molecules by Various Microbial Post-Modification Enzymes Revealed from Microbial Genomes
Bioassays of the Library of the Engineered Molecules for Drug Discovery
Comparative Genomics of Microbial Pathogens for Chemical Genomics
Identification of Target Pathogenesis-Related Genes by Bioinformatics Analysis.
Functional Characterization and structural Biology of Putative Pathogenesis-Related Proteins.
Structure-Based Drug Designs.
Bioassays of the Chemo-Enzymatic or Biosynthetic Molecules for Drug Discovery.
Enzymology and Protein Engineering
To study enzyme functions and mechanisms.
To create novel enzymes by DNA recombination and Mutagenesis
Applications of biocatalysts in novel organic transformation and biochemical industry.
Systems Biology
To connect genomic information with expression profiles (RNA and proteomics), biosynthetic and metabolic pathway/networks (metabolomics) and functional production of useful materials (functional genomics).
To analyze the above information systematically and organize them in silicon.
Other Interests
Drug Discovery and vaccine Development, including antibiotics, anticancer/antitumor and immunosuppressive agents to also kill and prevent pathogens of multi-drug resistance
Cell surface Engineering and Drug Targeting for cancer and tumor cell targeting.
Application of Biochips (DNA microarray) to resolve Drug and Gene Functions, to discover & study novel cellular genes/pathways and drug targets