RESULTS & IMPACT

TIP³DE is expected to deliver meaningful scientific, technical and translational results across its three-phase pipeline.

Scientific & Technical Impact

The project will identify specific dopaminergic modulation patterns associated with maladaptive eating behaviors, such as binge eating and restrictive intake, advancing understanding of the neurobiological mechanisms underlying obesity and EDs. TIP³DE will establish a comprehensive translational pipeline connecting preclinical research with human profiling and pilot clinical testing, integrating data from neuroimaging, psychophysiology, behavioral pharmacology and psychobiology as a model for future neurobehavioral intervention studies.

Societal & Economic Impact

By targeting the brain's reward system through novel dopaminergic allosteric modulators, the project aims to develop cost-effective alternatives to current pharmacological treatments for obesity, such as semaglutide or phentermine/topiramate. This approach supports a shift toward psychologically informed, brain-based and food-integrated therapies, recognizing that long-term solutions to the obesity epidemic must address both metabolic and neurobehavioral mechanisms.

Dissemination & Transfer

Scientific findings will be published in high-impact journals such as Neuropsychopharmacology, Appetite and Translational Psychiatry, and presented at major international conferences including the European College of Neuropsychopharmacology Congress and the European Congress on Obesity. Open-access platforms such as Open Research Europe, Zenodo and PubMed Central will ensure broad accessibility, while stakeholder engagement will be promoted through workshops with clinicians, nutritionists and mental health professionals.

Technology Transfer & Public Engagement

Technology transfer will be facilitated through partnerships with industry actors such as ALLOX, exploring intellectual property protection and commercialization pathways. TIP³DE will also participate in public engagement activities including the European Researchers' Night and the International Day of Women and Girls in Science, actively promoting gender equality in research leadership.